dbPTM

CLC4C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLC4C_HUMAN
UniProt AC	Q8WTT0
Protein Name	C-type lectin domain family 4 member C
Gene Name	CLEC4C
Organism	Homo sapiens (Human).
Sequence Length	213
Subcellular Localization	Cell membrane Single-pass type II membrane protein .
Protein Description	Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. [PubMed: 11748283]
Protein Sequence	MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	VPHNFMYSKTVKRLS CCCCHHCHHHHHHHH	15.29	24719451
110	N-linked_Glycosylation	SWTKSQKNCSVMGAD CCCCCCCCCEECCCC	18.69	UniProtKB CARBOHYD
137	N-linked_Glycosylation	IIQNLKRNSSYFLGL EEEECCCCCCEECCC	33.45	UniProtKB CARBOHYD
138	Phosphorylation	IQNLKRNSSYFLGLS EEECCCCCCEECCCC	30.37	22468782
139	Phosphorylation	QNLKRNSSYFLGLSD EECCCCCCEECCCCC	24.37	22468782
145	Phosphorylation	SSYFLGLSDPGGRRH CCEECCCCCCCCCCC	39.70	22468782
164	N-linked_Glycosylation	DQTPYNENVTFWHSG CCCCCCCCCEEEECC	34.19	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLC4C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLC4C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLC4C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NEK2_HUMAN	NEK2	physical	12386167

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLC4C_HUMAN

Related Literatures of Post-Translational Modification