CLC1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLC1_SCHPO
• UniProt AC: Q9USP6
• Protein Name: Clathrin light chain
• Gene Name: clc1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 229
• Subcellular Localization: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic face of coated pits and vesicles..
• Protein Description: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles..
• Protein Sequence: MSQFPALEDFDDGLVTAPVDDSKNNTDFLEREKLALGEDAGQFETPEDKDALLNFENDSEAEQTRFEQNFPPIDAEMQASGTFSAPKAPYMGQAEVHPPEDESGDPEPVRKWKEDQMKRIQERDESSKKLRESNIEKARKAIDDFYENFNDKRDKVIAKSRKEQEKLLEENESKSTGTTSWERILKLIDLSDKPEAHGRSTERFRELLISLAKDSNAPGAAGTTVSSSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	VTAPVDDSKNNTDFL EECCCCCCCCCCCHH	32.59	21712547
26	Phosphorylation	VDDSKNNTDFLEREK CCCCCCCCCHHHHHH	37.21	24763107
45	Phosphorylation	EDAGQFETPEDKDAL CCCCCCCCCCCHHHH	33.01	24763107
59	Phosphorylation	LLNFENDSEAEQTRF HHCCCCCHHHHHHHH	50.73	28889911
64	Phosphorylation	NDSEAEQTRFEQNFP CCHHHHHHHHHHCCC	28.91	21712547
103	Phosphorylation	VHPPEDESGDPEPVR ECCCCCCCCCCHHHH	61.90	27738172
228	Phosphorylation	AGTTVSSSS------ CCCCCCCCC------	32.34	25720772
229	Phosphorylation	GTTVSSSS------- CCCCCCCC-------	46.30	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLC1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLC1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLC1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of CLC1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.
PubMed: 18257517