CLASR_MOUSE - dbPTM
CLASR_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLASR_MOUSE
UniProt AC Q8CFC7
Protein Name CLK4-associating serine/arginine rich protein
Gene Name Clasrp
Organism Mus musculus (Mouse).
Sequence Length 668
Subcellular Localization Nucleus. Located in nuclear dots.
Isoform 2: Nucleus, nucleoplasm.
Protein Description Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family..
Protein Sequence MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAEVEKVAEKPEEEESPAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPSPGREEKITFITSFGGSDEEAAAAAAAAAASGAAPGKPPAPPQTGGPAPGRNASTRRRSSSSSASRTSSSRSSSRSSSRSRRGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSDGGSRDGHRYSRSPARRGGYVPRRRSRSRSRSGDRYKRGARGPRHHSSSHSRSSWSLSPSRSRSVTRSGSRSQSRSRSRSQSHSQSQSHSPSPPREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQERLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
93PhosphorylationLDHIPDYTPPLLTTI
HHCCCCCCCCCCCCC		26.3026643407
98PhosphorylationDYTPPLLTTISPEQE
CCCCCCCCCCCCCCC		29.7526643407
99PhosphorylationYTPPLLTTISPEQES
CCCCCCCCCCCCCCC		21.3021149613
101PhosphorylationPPLLTTISPEQESDE
CCCCCCCCCCCCCCH		21.9421149613
106PhosphorylationTISPEQESDERKCNY
CCCCCCCCCHHHCCH		44.4526643407
162PhosphorylationKLAEKKASIGYTYED
HHHHHHHHCCCEECC		25.9825266776
166PhosphorylationKKASIGYTYEDSTVA
HHHHCCCEECCCCHH		18.4130635358
263PhosphorylationEEEKAMYSGRRSRRQ
HHHHHHHHCHHHHHH		16.85-
267PhosphorylationAMYSGRRSRRQRREF
HHHHCHHHHHHHHHH		30.38-
285PhosphorylationRLRGRKISPPSYARR
HHCCCCCCCCHHCCC		33.5226824392
288PhosphorylationGRKISPPSYARRDSP
CCCCCCCHHCCCCCC		34.5025159016
289PhosphorylationRKISPPSYARRDSPT
CCCCCCHHCCCCCCC		15.2025159016
294PhosphorylationPSYARRDSPTYDPYK
CHHCCCCCCCCCCCC		19.8225521595
296PhosphorylationYARRDSPTYDPYKRS
HCCCCCCCCCCCCCC		44.5025159016
297PhosphorylationARRDSPTYDPYKRSP
CCCCCCCCCCCCCCC		20.5025159016
315PhosphorylationSSESRSRSRSPSPGR
CCHHHHCCCCCCCCH		38.0523684622
317PhosphorylationESRSRSRSPSPGREE
HHHHCCCCCCCCHHH		30.8622817900
319PhosphorylationRSRSRSPSPGREEKI
HHCCCCCCCCHHHCE		41.0322817900
327PhosphorylationPGREEKITFITSFGG
CCHHHCEEEEECCCC		21.7623684622
330PhosphorylationEEKITFITSFGGSDE
HHCEEEEECCCCCHH		17.5125619855
331PhosphorylationEKITFITSFGGSDEE
HCEEEEECCCCCHHH		19.6523684622
335PhosphorylationFITSFGGSDEEAAAA
EEECCCCCHHHHHHH		42.0827087446
349PhosphorylationAAAAAAASGAAPGKP
HHHHHHHHCCCCCCC		25.0025619855
380PhosphorylationTRRRSSSSSASRTSS
CCCCCCCCCCCCCCC		31.6922817900
411PhosphorylationRSGRHARSRSRSWSR
HCCHHHHHCCCCCHH		35.0829550500
413PhosphorylationGRHARSRSRSWSRSR
CHHHHHCCCCCHHHH		31.7329550500
415PhosphorylationHARSRSRSWSRSRSR
HHHHCCCCCHHHHHH		30.5629550500
417PhosphorylationRSRSRSWSRSRSRSR
HHCCCCCHHHHHHHH		22.9429550500
426PhosphorylationSRSRSRRYSRSRSRG
HHHHHHHHHCHHCCC		13.8123737553
427PhosphorylationRSRSRRYSRSRSRGR
HHHHHHHHCHHCCCC		23.2023737553
429PhosphorylationRSRRYSRSRSRGRRH
HHHHHHCHHCCCCCC		28.7723737553
447PhosphorylationGSRDGHRYSRSPARR
CCCCCCCCCCCHHHC		11.6323684622
448PhosphorylationSRDGHRYSRSPARRG
CCCCCCCCCCHHHCC		26.6626824392
450PhosphorylationDGHRYSRSPARRGGY
CCCCCCCCHHHCCCC		19.5726824392
454MethylationYSRSPARRGGYVPRR
CCCCHHHCCCCCCCC		45.0216288543
490PhosphorylationHSSSHSRSSWSLSPS
CCCCCCCCCCCCCCC		38.8928066266
491PhosphorylationSSSHSRSSWSLSPSR
CCCCCCCCCCCCCCC		21.4128066266
493PhosphorylationSHSRSSWSLSPSRSR
CCCCCCCCCCCCCCC		22.4026643407
495PhosphorylationSRSSWSLSPSRSRSV
CCCCCCCCCCCCCCC		18.4727555448
497PhosphorylationSSWSLSPSRSRSVTR
CCCCCCCCCCCCCCC		39.2426643407
499PhosphorylationWSLSPSRSRSVTRSG
CCCCCCCCCCCCCCC		32.9925777480
501PhosphorylationLSPSRSRSVTRSGSR
CCCCCCCCCCCCCCC		29.1425777480
503PhosphorylationPSRSRSVTRSGSRSQ
CCCCCCCCCCCCCCC		21.9925777480
505PhosphorylationRSRSVTRSGSRSQSR
CCCCCCCCCCCCCCC		31.5829895711
511PhosphorylationRSGSRSQSRSRSRSQ
CCCCCCCCCCCCCCC		33.21-
512MethylationSGSRSQSRSRSRSQS
CCCCCCCCCCCCCCC		28.5830989323
514MethylationSRSQSRSRSRSQSHS
CCCCCCCCCCCCCCC		34.6730989329
517PhosphorylationQSRSRSRSQSHSQSQ
CCCCCCCCCCCCCCC		36.9625777480
519PhosphorylationRSRSRSQSHSQSQSH
CCCCCCCCCCCCCCC		26.7625777480
521PhosphorylationRSRSQSHSQSQSHSP
CCCCCCCCCCCCCCC		36.4525777480
523PhosphorylationRSQSHSQSQSHSPSP
CCCCCCCCCCCCCCC		36.3425777480
525PhosphorylationQSHSQSQSHSPSPPR
CCCCCCCCCCCCCCH		31.0525777480
527PhosphorylationHSQSQSHSPSPPREK
CCCCCCCCCCCCHHH		32.1123684622
529PhosphorylationQSQSHSPSPPREKLT
CCCCCCCCCCHHHCC		51.0222817900
536PhosphorylationSPPREKLTRPAASPA
CCCHHHCCCCCCCHH		45.7525619855
541PhosphorylationKLTRPAASPAVGEKL
HCCCCCCCHHHHHHH		18.5926824392
567PhosphorylationGAAKPKLTPQERLKL
CCCCCCCCHHHHHHH		29.11-
594AcetylationDKKAAQEKMIQQEHE
HHHHHHHHHHHHHHH		29.2622826441
635PhosphorylationREEWERQYSRQSRSP
HHHHHHHHHHHCCCC		16.4329550500
636PhosphorylationEEWERQYSRQSRSPS
HHHHHHHHHHCCCCC		18.5929550500
639PhosphorylationERQYSRQSRSPSPRY
HHHHHHHCCCCCCCC		33.3525266776
641PhosphorylationQYSRQSRSPSPRYSR
HHHHHCCCCCCCCCC		34.6729899451
643PhosphorylationSRQSRSPSPRYSREY
HHHCCCCCCCCCCHH		24.2122324799
659PhosphorylationSSRRRSRSRSRSPHY
HHHHHHCCCCCCCCC		35.5425159016
661PhosphorylationRRRSRSRSRSPHYRH
HHHHCCCCCCCCCCC		38.0525159016
663PhosphorylationRSRSRSRSPHYRH--
HHCCCCCCCCCCC--		19.7825159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLASR_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLASR_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLASR_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLASR_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLASR_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294, AND MASSSPECTROMETRY.

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