CLAP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLAP2_RAT
• UniProt AC: Q99JD4
• Protein Name: CLIP-associating protein 2
• Gene Name: Clasp2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1286
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Golgi apparatus . Golgi apparatus, trans-Golgi network . Cell membrane . Cell projectio
• Protein Description: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex..
• Protein Sequence: MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVPAPKTPGNPVNSARKPGSAGGPKAGGTSKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSAVAGRVSVGGSKASPLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDGTASEDGRVRAKLSTPLVAVGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGAQRILVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGMSQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMSEPLKRDPKKEDGDTVCSGPGMSDPRAGGDAPDSSQPALDNKASLLHSVPLHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERIEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSAGADPTTDVSGQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KRICDYKSFDDEESV HHHCCCCCCCCHHCC	27.90	27097102
20	Phosphorylation	KSFDDEESVDGNRPS CCCCCHHCCCCCCCC	24.38	29779826
27	Phosphorylation	SVDGNRPSSAASAFK CCCCCCCCCCHHHCC	29.40	27097102
28	Phosphorylation	VDGNRPSSAASAFKV CCCCCCCCCHHHCCC	30.45	27097102
31	Phosphorylation	NRPSSAASAFKVPAP CCCCCCHHHCCCCCC	33.67	27097102
316	Phosphorylation	SLQTYLKSSGSVASL HHHHHHHHCCCCCCC	37.02	27097102
317	Phosphorylation	LQTYLKSSGSVASLP HHHHHHHCCCCCCCC	33.24	27097102
319	Phosphorylation	TYLKSSGSVASLPQS HHHHHCCCCCCCCCC	19.23	27097102
322	Phosphorylation	KSSGSVASLPQSDRS HHCCCCCCCCCCCCC	38.13	27097102
326	Phosphorylation	SVASLPQSDRSSSSS CCCCCCCCCCCCCCC	32.81	27097102
329	Phosphorylation	SLPQSDRSSSSSQES CCCCCCCCCCCCHHH	39.29	27097102
330	Phosphorylation	LPQSDRSSSSSQESL CCCCCCCCCCCHHHH	34.82	27097102
331	Phosphorylation	PQSDRSSSSSQESLN CCCCCCCCCCHHHHC	34.94	27097102
332	Phosphorylation	QSDRSSSSSQESLNR CCCCCCCCCHHHHCC	37.68	30411139
333	Phosphorylation	SDRSSSSSQESLNRP CCCCCCCCHHHHCCC	39.66	27097102
336	Phosphorylation	SSSSSQESLNRPFSS CCCCCHHHHCCCCCC	24.25	27097102
342	Phosphorylation	ESLNRPFSSKWSTAN HHHCCCCCCCCCCCC	33.42	27097102
343	Phosphorylation	SLNRPFSSKWSTANP HHCCCCCCCCCCCCH	38.22	27097102
370	Phosphorylation	KASPLPGSLQRSRSD CCCCCCCCCCCCCCC	21.27	28432305
374	Phosphorylation	LPGSLQRSRSDIDVN CCCCCCCCCCCCCHH	24.15	27097102
376	Phosphorylation	GSLQRSRSDIDVNAA CCCCCCCCCCCHHHH	39.92	28689409
410	Phosphorylation	AGALNPGSYASLEDT CCCCCCCCCCCCCCC	20.84	28432305
411	Phosphorylation	GALNPGSYASLEDTS CCCCCCCCCCCCCCC	13.21	27097102
413	Phosphorylation	LNPGSYASLEDTSDK CCCCCCCCCCCCCCC	24.86	27097102
417	Phosphorylation	SYASLEDTSDKMDGT CCCCCCCCCCCCCCC	29.47	28432305
418	Phosphorylation	YASLEDTSDKMDGTA CCCCCCCCCCCCCCC	47.78	28432305
459	Phosphorylation	RSRTKMVSQSQPGSR CCCCEEEECCCCCCC	22.18	28432305
461	Phosphorylation	RTKMVSQSQPGSRSG CCEEEECCCCCCCCC	30.73	27097102
465	Phosphorylation	VSQSQPGSRSGSPGR EECCCCCCCCCCCCC	29.92	27097102
467	Phosphorylation	QSQPGSRSGSPGRVL CCCCCCCCCCCCCEE	45.37	27097102
469	Phosphorylation	QPGSRSGSPGRVLTT CCCCCCCCCCCEEEH	25.98	27097102
475	Phosphorylation	GSPGRVLTTTALSTV CCCCCEEEHHHHHHC	21.17	23984901
476	Phosphorylation	SPGRVLTTTALSTVS CCCCEEEHHHHHHCC	13.10	23984901
477	Phosphorylation	PGRVLTTTALSTVSS CCCEEEHHHHHHCCC	21.99	23984901
480	Phosphorylation	VLTTTALSTVSSGAQ EEEHHHHHHCCCCCC	25.05	23984901
481	Phosphorylation	LTTTALSTVSSGAQR EEHHHHHHCCCCCCE	25.84	23984901
483	Phosphorylation	TTALSTVSSGAQRIL HHHHHHCCCCCCEEE	24.12	23984901
484	Phosphorylation	TALSTVSSGAQRILV HHHHHCCCCCCEEEE	33.54	23984901
493	Phosphorylation	AQRILVNSASAQKRS CCEEEECCHHHHHHC	19.00	28432305
495	Phosphorylation	RILVNSASAQKRSKI EEEECCHHHHHHCCC	30.93	28432305
505	Phosphorylation	KRSKIPRSQGCSREA HHCCCCHHHCCCCCC	26.10	25575281
509	Phosphorylation	IPRSQGCSREASPSR CCHHHCCCCCCCHHH	39.72	25575281
513	Phosphorylation	QGCSREASPSRLSVA HCCCCCCCHHHHHHH	20.75	25575281
515	Phosphorylation	CSREASPSRLSVARS CCCCCCHHHHHHHHH	43.27	25575281
518	Phosphorylation	EASPSRLSVARSSRI CCCHHHHHHHHHCCC	16.78	25575281
529	Phosphorylation	SSRIPRPSVSQGCSR HCCCCCCCHHHCCCH	35.36	27097102
531	Phosphorylation	RIPRPSVSQGCSREA CCCCCCHHHCCCHHH	25.78	27097102
535	Phosphorylation	PSVSQGCSREASRES CCHHHCCCHHHHHHC	39.72	27097102
542	Phosphorylation	SREASRESSRDTSPV CHHHHHHCCCCCCCC	29.57	23984901
543	Phosphorylation	REASRESSRDTSPVR HHHHHHCCCCCCCCC	29.44	23984901
546	Phosphorylation	SRESSRDTSPVRSFQ HHHCCCCCCCCCCCC	33.54	23984901
547	Phosphorylation	RESSRDTSPVRSFQP HHCCCCCCCCCCCCC	26.20	23984901
551	Phosphorylation	RDTSPVRSFQPLGPG CCCCCCCCCCCCCCC	28.59	23984901
568	Phosphorylation	MSQSSRLSSSVSAMR CCHHHCCCCCCHHHH	21.32	23984901
569	Phosphorylation	SQSSRLSSSVSAMRV CHHHCCCCCCHHHHH	39.07	28432305
570	Phosphorylation	QSSRLSSSVSAMRVL HHHCCCCCCHHHHHH	19.40	27097102
572	Phosphorylation	SRLSSSVSAMRVLNT HCCCCCCHHHHHHCC	20.49	28432305
579	Phosphorylation	SAMRVLNTGSDVEEA HHHHHHCCCCCHHHH	33.62	22673903
581	Phosphorylation	MRVLNTGSDVEEAVA HHHHCCCCCHHHHHH	36.12	25403869
607	Phosphorylation	KKPARRRYESYGMHS CCCCHHHHHHCCCCC	13.86	27097102
609	Phosphorylation	PARRRYESYGMHSDD CCHHHHHHCCCCCCC	20.32	27097102
610	Phosphorylation	ARRRYESYGMHSDDD CHHHHHHCCCCCCCC	13.41	27097102
614	Phosphorylation	YESYGMHSDDDANSD HHHCCCCCCCCCCCC	33.57	27097102
620	Phosphorylation	HSDDDANSDASSACS CCCCCCCCCHHHHHH	35.95	-
637	Phosphorylation	SYSSRNGSIPTYMRQ HHHCCCCCCCCCCCC	29.01	27097102
640	Phosphorylation	SRNGSIPTYMRQTED CCCCCCCCCCCCHHH	28.42	25575281
744	Phosphorylation	MGADLLGSVQAKVQK CCCHHHHHHHHHHHH	15.83	26022182
779	Phosphorylation	FTVDQTQTPSLKVKV EECCCCCCCCHHHHH	20.45	27097102
785	Ubiquitination	QTPSLKVKVAILKYI CCCCHHHHHHHHHHH	25.10	-
878	Phosphorylation	LRNTGNGTQSSMGSP HHHCCCCCCCCCCCC	29.31	27097102
880	Phosphorylation	NTGNGTQSSMGSPLT HCCCCCCCCCCCCCC	23.33	27097102
881	Phosphorylation	TGNGTQSSMGSPLTR CCCCCCCCCCCCCCC	19.83	27097102
884	Phosphorylation	GTQSSMGSPLTRPTP CCCCCCCCCCCCCCC	14.22	27097102
887	Phosphorylation	SSMGSPLTRPTPRSP CCCCCCCCCCCCCCC	37.68	27097102
890	Phosphorylation	GSPLTRPTPRSPANW CCCCCCCCCCCCCCC	28.22	27097102
893	Phosphorylation	LTRPTPRSPANWSSP CCCCCCCCCCCCCCC	29.57	22673903
898	Phosphorylation	PRSPANWSSPLTSPT CCCCCCCCCCCCCCC	23.14	22673903
899	Phosphorylation	RSPANWSSPLTSPTN CCCCCCCCCCCCCCC	18.62	22673903
902	Phosphorylation	ANWSSPLTSPTNTSQ CCCCCCCCCCCCCCC	35.72	22673903
903	Phosphorylation	NWSSPLTSPTNTSQN CCCCCCCCCCCCCCC	37.09	22673903
905	Phosphorylation	SSPLTSPTNTSQNTL CCCCCCCCCCCCCCC	51.39	22673903
907	Phosphorylation	PLTSPTNTSQNTLSP CCCCCCCCCCCCCCC	33.88	22673903
908	Phosphorylation	LTSPTNTSQNTLSPS CCCCCCCCCCCCCCH	24.41	22673903
911	Phosphorylation	PTNTSQNTLSPSAFD CCCCCCCCCCCHHHC	22.45	22673903
913	Phosphorylation	NTSQNTLSPSAFDYD CCCCCCCCCHHHCCC	18.12	22673903
944	Phosphorylation	TEAIQNFSFRSQEDM HHHHHHCCCCCHHCC	27.57	27097102
947	Phosphorylation	IQNFSFRSQEDMSEP HHHCCCCCHHCCCCC	35.59	27097102
952	Phosphorylation	FRSQEDMSEPLKRDP CCCHHCCCCCCCCCC	48.67	27097102
995	Phosphorylation	PALDNKASLLHSVPL CCCCCHHHHHHCCCC	32.83	27097102
999	Phosphorylation	NKASLLHSVPLHSSP CHHHHHHCCCCCCCC	25.96	27097102
1004	Phosphorylation	LHSVPLHSSPRSRDY HHCCCCCCCCCCCCC	50.12	27097102
1005	Phosphorylation	HSVPLHSSPRSRDYN HCCCCCCCCCCCCCC	17.37	27097102
1014	Phosphorylation	RSRDYNPYNYSDSIS CCCCCCCCCCCCCCC	24.08	27097102
1016	Phosphorylation	RDYNPYNYSDSISPF CCCCCCCCCCCCCCC	14.17	27097102
1017	Phosphorylation	DYNPYNYSDSISPFN CCCCCCCCCCCCCCC	22.65	27097102
1019	Phosphorylation	NPYNYSDSISPFNKS CCCCCCCCCCCCCHH	21.01	27097102
1021	Phosphorylation	YNYSDSISPFNKSAL CCCCCCCCCCCHHHH	27.65	27097102
1132	Phosphorylation	QPARFKNYAELTVMK CCHHCCCHHHHHHHH	11.31	-
1181	Phosphorylation	VLCPIIQTADYPINL HHHHHHHCCCCCCHH	15.87	-
1271	Phosphorylation	LYIKRAQTGSAGADP HHHHHHHCCCCCCCC	31.92	22673903
1273	Phosphorylation	IKRAQTGSAGADPTT HHHHHCCCCCCCCCC	27.24	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLAP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLAP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLAP2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CLAP2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.