CL17A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CL17A_HUMAN
• UniProt AC: Q6ZS10
• Protein Name: C-type lectin domain family 17, member A
• Gene Name: CLEC17A
• Organism: Homo sapiens (Human).
• Sequence Length: 378
• Subcellular Localization: Membrane ; Single-pass type II membrane protein . In fibroblasts, expressed on the cell surface.
• Protein Description: Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues..
• Protein Sequence: MHNLYSITGYPDPPGTMEEEEEDDDYENSTPPYKDLPPKPGTMEEEEEDDDYENSTPPYKDLPPKPGTMEEEEEDDDYENSTPPYKDLPPKPGSSAPPRPPRAAKETEKPPLPCKPRNMTGLDLAAVTCPPPQLAVNLEPSPLQPSLAATPVPWLNQRSGGPGCCQKRWMVYLCLLVVTSLFLGCLGLTVTLIKYQELMEELRMLSFQQMTWRTNMTGMAGLAGLKHDIARVRADTNQSLVELWGLLDCRRITCPEGWLPFEGKCYYFSPSTKSWDEARMFCQENYSHLVIINSFAEHNFVAKAHGSPRVYWLGLNDRAQEGDWRWLDGSPVTLSFWEPEEPNNIHDEDCATMNKGGTWNDLSCYKTTYWICERKCSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	EEEEDDDYENSTPPY CHHCCCCCCCCCCCC	24.81	-
41	Ubiquitination	KDLPPKPGTMEEEEE CCCCCCCCCCCCHHC	43.76	25015289
47	Ubiquitination	PGTMEEEEEDDDYEN CCCCCCHHCCCCCCC	70.75	25015289
52	Phosphorylation	EEEEDDDYENSTPPY CHHCCCCCCCCCCCC	24.81	28348404
55	Phosphorylation	EDDDYENSTPPYKDL CCCCCCCCCCCCCCC	30.28	28348404
56	Phosphorylation	DDDYENSTPPYKDLP CCCCCCCCCCCCCCC	39.60	28348404
78	Phosphorylation	EEEEDDDYENSTPPY CHHCCCCCCCCCCCC	24.81	28348404
81	Phosphorylation	EDDDYENSTPPYKDL CCCCCCCCCCCCCCC	30.28	28348404
82	Phosphorylation	DDDYENSTPPYKDLP CCCCCCCCCCCCCCC	39.60	28348404
109	Ubiquitination	RAAKETEKPPLPCKP CCCCCCCCCCCCCCC	60.39	25015289
115	Ubiquitination	EKPPLPCKPRNMTGL CCCCCCCCCCCCCCC	45.10	25015289
120	Phosphorylation	PCKPRNMTGLDLAAV CCCCCCCCCCCEEEE	37.84	28348404
215	N-linked_Glycosylation	QQMTWRTNMTGMAGL HHHHHHCCCCCHHHH	19.90	UniProtKB CARBOHYD
237	N-linked_Glycosylation	ARVRADTNQSLVELW HHHHCCCCCHHHHHH	29.95	UniProtKB CARBOHYD
285	N-linked_Glycosylation	ARMFCQENYSHLVII HHHHHHHCCCEEEEE	20.09	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CL17A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CL17A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CL17A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CL17A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.