CKP2L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CKP2L_MOUSE
• UniProt AC: Q7TS74
• Protein Name: Cytoskeleton-associated protein 2-like
• Gene Name: Ckap2l
• Organism: Mus musculus (Mouse).
• Sequence Length: 745
• Subcellular Localization: Cytoplasm, cytoskeleton, spindle pole . Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase.
• Protein Description: Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells..
• Protein Sequence: MVGPGPTASAAAEERWQKLQEYLAAKGKLKDPNAKPYLKAKNICPKPPPSKYTPGPKKDVSNHVLPSKTTRPINIKFQTKPASITASQKPESKPPKLPSRGLTSRCFSSNTDCKQSSKPQQQPRAVSFTAGLSRNPRQCPDIQELKTKQQQQAHGGNAKCTHPETNTHAAKQPVDGFPDETNKENLPQALPKPEKPDPELHSIRKPNTGSSNQTQKGLAPKQILSKSSVTQTALKDRANKQFIRNTQIRTQAVKSRPRPTVADSTRPREKPPQTAPSHSVPAHNKTQTSKKPMTKNTQDITVNRVRYGKPNETKIESCPATEQKVKHTKPSSQLNVLQGGHNSRHPNMRQDQKPVQPHLGPQTSCVLQKSRAISQRPNLTARNFNSVIPSTPNMRANKTLNNKYNNIFQQKAQTLDSKFRKFPPQSHFLNKTAPRTQASTAAASRKGAPSATQTHPHGKKPEGEDRRKQLEEWQKSKGKTYKRPPMKFKTKRKVIEEMNTSFWKSIEREEEEKKAQLELSKKIDSTLTECLRLIEEGVLPNEIFTIVSSIPEAEKFAKFWVCKAKLLASKGTFDAIGLYEEAIQNGATPVQELQEVLNVLQDPCRSTEAVTSDTSAAGTNTTSAEELAKEESEQPCPSLTEMEPIAAAAPRIPVSEWDNHGIKLQVAPIPRICGMPEVQDMKLITPVRRSARIERTVARYPEMLQEHDVVVASLNELLEVDKTECFIFRENEALPVTLGFEVLES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	KDPNAKPYLKAKNIC CCCCCCCCCCCCCCC	21.81	29514104
127	Phosphorylation	QQQPRAVSFTAGLSR CCCCCEEEEHHCCCC	18.85	22006019
225	Phosphorylation	LAPKQILSKSSVTQT CCHHHHHCCCCCHHH	31.92	24719451
390	Phosphorylation	NFNSVIPSTPNMRAN CHHCCCCCCCCHHCC	45.43	24759943
391	Phosphorylation	FNSVIPSTPNMRANK HHCCCCCCCCHHCCH	17.21	24759943
426	Phosphorylation	FRKFPPQSHFLNKTA HHHCCCHHHHCCCCC	23.21	26643407
432	Phosphorylation	QSHFLNKTAPRTQAS HHHHCCCCCCCCHHH	40.60	29550500
436	Phosphorylation	LNKTAPRTQASTAAA CCCCCCCCHHHHHHH	27.68	29550500
439	Phosphorylation	TAPRTQASTAAASRK CCCCCHHHHHHHHHC	14.57	29550500
500	Phosphorylation	KVIEEMNTSFWKSIE HHHHHHHHHHHHHHH	24.80	28066266
501	Phosphorylation	VIEEMNTSFWKSIER HHHHHHHHHHHHHHH	24.89	28066266
505	Phosphorylation	MNTSFWKSIEREEEE HHHHHHHHHHHHHHH	21.93	29514104
685	Phosphorylation	VQDMKLITPVRRSAR CCCCEECCCHHHHHH	26.60	29514104
690	Phosphorylation	LITPVRRSARIERTV ECCCHHHHHHHHHHH	16.01	29514104
745	Phosphorylation	LGFEVLES------- EEEEECCC-------	41.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CKP2L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CKP2L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CKP2L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CKP2L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.