CKLF8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CKLF8_HUMAN
• UniProt AC: Q8IZV2
• Protein Name: CKLF-like MARVEL transmembrane domain-containing protein 8
• Gene Name: CMTM8
• Organism: Homo sapiens (Human).
• Sequence Length: 173
• Subcellular Localization: Isoform 1: Membrane; Multi-pass membrane protein.; Isoform 2: Cytoplasm. Nucleus.
• Protein Sequence: MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	EEPQRARSHTVTTTA CCCCHHHCCCCCCCH	23.64	27732954
11	Phosphorylation	PQRARSHTVTTTASS CCHHHCCCCCCCHHH	22.31	27732954
13	Phosphorylation	RARSHTVTTTASSFA HHHCCCCCCCHHHHH	21.42	28857561
14	Phosphorylation	ARSHTVTTTASSFAE HHCCCCCCCHHHHHH	18.94	28857561
15	Phosphorylation	RSHTVTTTASSFAEN HCCCCCCCHHHHHHH	18.38	28857561
17	Phosphorylation	HTVTTTASSFAENFS CCCCCCHHHHHHHCC	24.73	28857561
18	Phosphorylation	TVTTTASSFAENFST CCCCCHHHHHHHCCC	26.47	28857561
24	Phosphorylation	SSFAENFSTSSSSFA HHHHHHCCCCCCCCC	38.67	26657352
25	Phosphorylation	SFAENFSTSSSSFAY HHHHHCCCCCCCCCC	28.61	26657352
26	Phosphorylation	FAENFSTSSSSFAYD HHHHCCCCCCCCCCC	27.33	28152594
27	Phosphorylation	AENFSTSSSSFAYDR HHHCCCCCCCCCCCH	30.04	28152594
28	Phosphorylation	ENFSTSSSSFAYDRE HHCCCCCCCCCCCHH	29.28	28152594
29	Phosphorylation	NFSTSSSSFAYDREF HCCCCCCCCCCCHHH	18.82	28152594
32	Phosphorylation	TSSSSFAYDREFLRT CCCCCCCCCHHHHHH	17.33	25022875
131	Phosphorylation	VVDASSVSPERDSHN ECCHHHCCCCCCCCC	24.00	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CKLF8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CKLF8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CKLF8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CKLF8_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.