dbPTM

CKI2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CKI2_SCHPO
UniProt AC	P40234
Protein Name	Casein kinase I homolog 2
Gene Name	cki2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	435
Subcellular Localization	Cytoplasm.
Protein Description	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology..
Protein Sequence	MNSQTSVVGVHYRVGRKIGEGSFGVIFDGMNLLNNQLIAIKFEPKKSEAPQLRDEYRTYKLLVGNAGIPNVYYFGQEGLHNILVIDLLGPSLEDLFEWCGRRFSVKTVAMTAKQMLSRVQTIHEKNLVYRDIKPDNFLIGRPSSRNANMVYMVDFGMAKYYRDPKTKQHIPYSERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGSLPWQGLKAANNKHKYEKISEKKQSTSISELCAGFPNEFSKYMTYVRSLEFDEEPDYAFLQELFDDVLRANGDTNDGVYDWMLLNDGKGWESSSSHFSVVAMKRRKNYLGLNVVQNDDSRKKNSTLQTQNMRFKSSYGVRGPRNYSSFDALPSKNAPLVRQEQSASKKTIYAHSSRGYDRVRPMYVSQPSNNAVGVNHPNDNSDSEAKGGFFDMICCRCFS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
333	Phosphorylation	NVVQNDDSRKKNSTL EEEECCCCCCCCCCC	49.19	24763107
338	Phosphorylation	DDSRKKNSTLQTQNM CCCCCCCCCCCHHHH	39.10	21712547
339	Phosphorylation	DSRKKNSTLQTQNMR CCCCCCCCCCHHHHH	32.07	24763107
342	Phosphorylation	KKNSTLQTQNMRFKS CCCCCCCHHHHHCCC	25.64	24763107
360	Phosphorylation	VRGPRNYSSFDALPS CCCCCCCCCCCCCCC	28.25	29996109
361	Phosphorylation	RGPRNYSSFDALPSK CCCCCCCCCCCCCCC	19.45	28889911
378	Phosphorylation	PLVRQEQSASKKTIY CCCCCCCCCCCCEEE	33.48	21712547
380	Phosphorylation	VRQEQSASKKTIYAH CCCCCCCCCCEEEEE	39.67	24763107
383	Phosphorylation	EQSASKKTIYAHSSR CCCCCCCEEEEECCC	23.98	29996109
388	Phosphorylation	KKTIYAHSSRGYDRV CCEEEEECCCCCCCC	17.35	28889911
389	Phosphorylation	KTIYAHSSRGYDRVR CEEEEECCCCCCCCC	21.62	29996109
404	Phosphorylation	PMYVSQPSNNAVGVN CEEECCCCCCCCCCC	34.77	25720772
417	Phosphorylation	VNHPNDNSDSEAKGG CCCCCCCCCCCCCCC	45.43	29996109
419	Phosphorylation	HPNDNSDSEAKGGFF CCCCCCCCCCCCCEE	39.00	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CKI2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CKI2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CKI2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CKI2_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CKI2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, AND MASSSPECTROMETRY.	18257517 [Abstract]