dbPTM

CKB2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CKB2_CAEEL
UniProt AC	P46559
Protein Name	Choline kinase B2 {ECO:0000303\|PubMed:12758145}
Gene Name	ckb-2
Organism	Caenorhabditis elegans.
Sequence Length	369
Subcellular Localization
Protein Description	Catalyzes the first step in phosphatidylcholine biosynthesis. Phosphorylates choline..
Protein Sequence	MTAIEKFFTEKSPDSEQVLLKVIELGIDFLGGEWKNVDKSQVNVSRVHGGQSNHMFHVTSSTSATPYLLRIHRQPPSQVFTDTVNLAIFSERGLGPKLYGFFEGGRMEEFLPSKTFDVNDVLVPENSRKIGAIFPLYHSINVPVSKSRRCVHLMREWLNGYESLGGGDYEILPTTVNYSDHPKSVSIKDLNHEIDNFEKWSTEIFEHTLVFSHNDLASTNILELNSTKELVLIDWEFGTYNWRGFDLAMHLSETAIDYRVPFPPGIKMNGDLIDNPPNIQIFCEAYVEADKKLKNRSPSDPTAEVKALIQECQFFWPLTNLFWALSAMKHSLLKFENGVDLDVQARDRLAVYFHLKPRSQKIYEELSKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
297	Phosphorylation	DKKLKNRSPSDPTAE HHHHCCCCCCCCHHH	28854356
299	Phosphorylation	KLKNRSPSDPTAEVK HHCCCCCCCCHHHHH	19530675
302	Phosphorylation	NRSPSDPTAEVKALI CCCCCCCHHHHHHHH	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CKB2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CKB2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CKB2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CKB2_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CKB2_CAEEL

Related Literatures of Post-Translational Modification