CISD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CISD3_MOUSE
• UniProt AC: B1AR13
• Protein Name: CDGSH iron-sulfur domain-containing protein 3, mitochondrial
• Gene Name: Cisd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 137
• Subcellular Localization: Mitochondrion .
• Protein Description: Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function..
• Protein Sequence: MGFRRLSFPTDFIFLFPNHICLPALSKPYQRREISSWLARWFPKDPAKPVVAQKTPIRLELVAGKTYRWCVCGRSKNQPFCDGSHFFQRTGLSPLKFKAQETRTVALCTCKATQRPPYCDGTHKSEQVQKAEVGSPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Acetylation	WFPKDPAKPVVAQKT HCCCCCCCCEEECCC	43.67	23954790
65	Acetylation	RLELVAGKTYRWCVC EEEEECCCEEEEEEE	32.42	23806337
65	Succinylation	RLELVAGKTYRWCVC EEEEECCCEEEEEEE	32.42	-
65	Succinylation	RLELVAGKTYRWCVC EEEEECCCEEEEEEE	32.42	23806337
81	S-palmitoylation	RSKNQPFCDGSHFFQ CCCCCCCCCCCCCCC	8.03	28526873
81	S-nitrosylation	RSKNQPFCDGSHFFQ CCCCCCCCCCCCCCC	8.03	21278135
81	S-nitrosocysteine	RSKNQPFCDGSHFFQ CCCCCCCCCCCCCCC	8.03	-
90	Phosphorylation	GSHFFQRTGLSPLKF CCCCCCCCCCCCCCC	31.52	22807455
93	Phosphorylation	FFQRTGLSPLKFKAQ CCCCCCCCCCCCCCC	29.54	24453211
96	Acetylation	RTGLSPLKFKAQETR CCCCCCCCCCCCCCE	48.48	23576753
96	Succinylation	RTGLSPLKFKAQETR CCCCCCCCCCCCCCE	48.48	23806337
98	Acetylation	GLSPLKFKAQETRTV CCCCCCCCCCCCEEE	47.80	23864654
119	S-nitrosocysteine	ATQRPPYCDGTHKSE CCCCCCCCCCCCCCC	4.86	-
119	S-nitrosylation	ATQRPPYCDGTHKSE CCCCCCCCCCCCCCC	4.86	21278135
119	S-palmitoylation	ATQRPPYCDGTHKSE CCCCCCCCCCCCCCC	4.86	28526873
124	Acetylation	PYCDGTHKSEQVQKA CCCCCCCCCCCHHHH	56.37	23576753
124	Succinylation	PYCDGTHKSEQVQKA CCCCCCCCCCCHHHH	56.37	-
124	Succinylation	PYCDGTHKSEQVQKA CCCCCCCCCCCHHHH	56.37	23806337
130	Acetylation	HKSEQVQKAEVGSPL CCCCCHHHHCCCCCC	47.89	23576753
135	Phosphorylation	VQKAEVGSPL----- HHHHCCCCCC-----	28.36	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CISD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CISD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CISD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CISD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.