CISD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CISD1_MOUSE
• UniProt AC: Q91WS0
• Protein Name: CDGSH iron-sulfur domain-containing protein 1
• Gene Name: Cisd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 108
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass type III membrane protein .
• Protein Description: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity)..
• Protein Sequence: MGLSSNSAVRVEWIAAVTFAAGTAALGYLAYKKFYAKENRTKAMVNLQIQKDNPKVVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHIKHNEETGDNVGPLIIKKKET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGLSSNSAVRVE ---CCCCCCCCCCHH	39.59	28464351
7	Phosphorylation	-MGLSSNSAVRVEWI -CCCCCCCCCCHHHH	30.04	28464351
37	Malonylation	AYKKFYAKENRTKAM HHHHHHCCCCCCCEE	44.11	26320211
37	Acetylation	AYKKFYAKENRTKAM HHHHHHCCCCCCCEE	44.11	23201123
42	Malonylation	YAKENRTKAMVNLQI HCCCCCCCEEEEEEE	31.11	26320211
55	Acetylation	QIQKDNPKVVHAFDM EECCCCCCEEEEEEH	64.24	23576753
55	Malonylation	QIQKDNPKVVHAFDM EECCCCCCEEEEEEH	64.24	26320211
55	Ubiquitination	QIQKDNPKVVHAFDM EECCCCCCEEEEEEH	64.24	27667366
68	Ubiquitination	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	-
68	Acetylation	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	23576753
68	Malonylation	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	26320211
72	S-nitrosocysteine	LGDKAVYCRCWRSKK HCCCEEEEEECCCCC	2.02	-
72	Glutathionylation	LGDKAVYCRCWRSKK HCCCEEEEEECCCCC	2.02	24333276
72	S-nitrosylation	LGDKAVYCRCWRSKK HCCCEEEEEECCCCC	2.02	21278135
78	Acetylation	YCRCWRSKKFPFCDG EEEECCCCCCCCCCC	50.27	24062335
79	Acetylation	CRCWRSKKFPFCDGA EEECCCCCCCCCCCC	60.56	24062335
79	Malonylation	CRCWRSKKFPFCDGA EEECCCCCCCCCCCC	60.56	26320211
83	S-nitrosocysteine	RSKKFPFCDGAHIKH CCCCCCCCCCCEEEC	4.86	-
83	S-nitrosylation	RSKKFPFCDGAHIKH CCCCCCCCCCCEEEC	4.86	21278135
89	Acetylation	FCDGAHIKHNEETGD CCCCCEEECCCCCCC	30.43	24062335
104	Acetylation	NVGPLIIKKKET--- CCCCEEEEECCC---	51.29	23576753
104	Ubiquitination	NVGPLIIKKKET--- CCCCEEEEECCC---	51.29	-
104	Malonylation	NVGPLIIKKKET--- CCCCEEEEECCC---	51.29	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CISD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CISD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CISD1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CISD1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-104, AND MASS SPECTROMETRY.
PubMed: 16916647