CHD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHD1_MOUSE
• UniProt AC: P40201
• Protein Name: Chromodomain-helicase-DNA-binding protein 1
• Gene Name: Chd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1711
• Subcellular Localization: Nucleus . Cytoplasm . Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis (PubMed:7739555).
• Protein Description: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (By similarity). Required for maintaining open chromatin and pluripotency in embryonic stem cells. [PubMed: 19587682 Is also associated with histone deacetylase (HDAC) activity]
• Protein Sequence: MNGHSDEESVRNGSGESSQSGDDCGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSDSGSQSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAMLRKQPQQAQQQRPASSNSGSEEDSSSSEDSDDSSSGAKRKKHNDEDWQMSGSGSPSQSGSDSESEEERDKSSCDGTESDYEPKNKVRSRKPQNRSKSKNGKKILGQKKRQIDSSEDEDDEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEDEEFETIERVMDCRVGRKGATGATTTIYAVEADGDPNAGFERNKEPGDIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGLPDYYCKWQGLPYSECSWEDGALISKKFQTCIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWMHPQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLSVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEEIIPEEQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISERKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCVKALKDSSSGTERAGGRLGKVKGPTFRISGVQVNAKLVIAHEDELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKREAQRLCGAGGSKRRKTRAKKSKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLNDSKPESKDRSKKSVVSDAPVHITASGEPVPIAEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYSNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNVATTHVIRNPDMERLKENTNHDDSSRDSYSSDRHLSQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHREWDHYRQDSRYYSDREKHRKLDDHRSREHRPSLEGGLKDRCHSDHRSHSDHRMHSDHRSSSEHTHHKSSRDYRYLSDWQLDHRAASSGPRSPLDQRSPYGSRSPFEHSAEHRSTPEHTWSSRKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Oxidation	-------MNGHSDEE -------CCCCCCHH	52.80	17242355
5	Phosphorylation	---MNGHSDEESVRN ---CCCCCCHHHHCC	48.38	23684622
9	Phosphorylation	NGHSDEESVRNGSGE CCCCCHHHHCCCCCC	25.08	21149613
89	Phosphorylation	DGAEFWKSSPSILAV CHHHHHHCCHHHHHH	37.77	21082442
90	Phosphorylation	GAEFWKSSPSILAVQ HHHHHHCCHHHHHHH	20.95	22942356
92	Phosphorylation	EFWKSSPSILAVQRS HHHHCCHHHHHHHHH	31.98	25619855
173	Phosphorylation	EEERDKSSCDGTESD HHHHHHHCCCCCCCC	23.20	25195567
214	Phosphorylation	QKKRQIDSSEDEDDE HHHHCCCCCCCCCCC	36.94	27087446
215	Phosphorylation	KKRQIDSSEDEDDED HHHCCCCCCCCCCCC	45.37	27087446
235	Phosphorylation	RSSRRQATVNVSYKE CCCCCEEEEECCCCC	12.32	-
239	Phosphorylation	RQATVNVSYKEDEEM CEEEEECCCCCCHHC	25.86	-
248	Phosphorylation	KEDEEMKTDSDDLLE CCCHHCCCCCHHHHH	39.15	21149613
250	Phosphorylation	DEEMKTDSDDLLEVC CHHCCCCCHHHHHHH	37.95	21149613
469	Phosphorylation	VALKKQPSYIGGHEG EEECCCCCCCCCCCC	27.21	28285833
915	Phosphorylation	YRLVTKGSVEEDILE EEEECCCCHHHHHHH	28.10	22705319
944	Phosphorylation	RMDTTGKTVLHTGSA EECCCCCEEEECCCC	29.64	28576409
1023	Phosphorylation	QFKVANFSNMDEDDI HCEECCCCCCCHHHC	30.93	-
1038	Phosphorylation	ELEPERNSKNWEEII CCCCHHCCCCHHHHC	33.32	25619855
1066	Phosphorylation	QKELEEIYMLPRMRN HHHHHHHHHHHHHHH	8.90	22817900
1079	Phosphorylation	RNCAKQISFNGSEGR HHHHHHHCCCCCCCC	15.34	27600695
1083	Phosphorylation	KQISFNGSEGRRSRS HHHCCCCCCCCCCCC	37.67	28285833
1088	Phosphorylation	NGSEGRRSRSRRYSG CCCCCCCCCCCCCCC	32.99	29514104
1093	Phosphorylation	RRSRSRRYSGSDSDS CCCCCCCCCCCCCCC	19.10	25159016
1094	Phosphorylation	RSRSRRYSGSDSDSI CCCCCCCCCCCCCCH	29.97	23684622
1096	Phosphorylation	RSRRYSGSDSDSISE CCCCCCCCCCCCHHH	28.18	23684622
1098	Phosphorylation	RRYSGSDSDSISERK CCCCCCCCCCHHHCC	34.65	23684622
1100	Phosphorylation	YSGSDSDSISERKRP CCCCCCCCHHHCCCC	31.78	23429704
1102	Phosphorylation	GSDSDSISERKRPKK CCCCCCHHHCCCCCC	34.99	25159016
1125	Phosphorylation	RENIKGFSDAEIRRF HHHCCCCCHHHHHHH	44.58	28066266
1159	Phosphorylation	DAELVDKSETDLRRL CHHHCCCCHHHHHHH	41.06	-
1181	Phosphorylation	CVKALKDSSSGTERA HHHHHHCCCCCCCCC	25.47	30635358
1182	Phosphorylation	VKALKDSSSGTERAG HHHHHCCCCCCCCCC	42.81	30635358
1183	Phosphorylation	KALKDSSSGTERAGG HHHHCCCCCCCCCCC	54.40	30635358
1185	Phosphorylation	LKDSSSGTERAGGRL HHCCCCCCCCCCCCC	25.01	30635358
1228	Phosphorylation	PLHKSIPSDPEERKQ CCCCCCCCCHHHHHC	65.22	26824392
1281	Phosphorylation	IKMDPDLSLTHKILP EEECCCCCCCEECCC	38.30	20531401
1283	Phosphorylation	MDPDLSLTHKILPDD ECCCCCCCEECCCCC	20.11	20531401
1353	Phosphorylation	KVKEEIKSDSSPLPS HHHHHHCCCCCCCCC	48.68	22817900
1355	Phosphorylation	KEEIKSDSSPLPSEK HHHHCCCCCCCCCCC	40.73	22817900
1356	Phosphorylation	EEIKSDSSPLPSEKS HHHCCCCCCCCCCCC	35.13	22817900
1360	Phosphorylation	SDSSPLPSEKSDEDD CCCCCCCCCCCCCCC	66.40	22817900
1363	Phosphorylation	SPLPSEKSDEDDDKL CCCCCCCCCCCCCCC	42.03	29550500
1373	Phosphorylation	DDDKLNDSKPESKDR CCCCCCCCCCCCCCC	49.38	-
1396	Phosphorylation	APVHITASGEPVPIA CCEEEEECCCCCCCC	34.73	22006019
1541	Phosphorylation	NTNHDDSSRDSYSSD HCCCCCCCCCCHHCH	47.29	30387612
1544	Phosphorylation	HDDSSRDSYSSDRHL CCCCCCCCHHCHHHH	26.29	27149854
1545	Phosphorylation	DDSSRDSYSSDRHLS CCCCCCCHHCHHHHH	19.24	27149854
1546	Phosphorylation	DSSRDSYSSDRHLSQ CCCCCCHHCHHHHHH	29.70	27149854
1547	Phosphorylation	SSRDSYSSDRHLSQY CCCCCHHCHHHHHHH	30.36	27149854
1552	Phosphorylation	YSSDRHLSQYHDHHK HHCHHHHHHHHHHCC	23.67	27149854
1554	Phosphorylation	SDRHLSQYHDHHKDR CHHHHHHHHHHCCCC	13.07	27149854
1600	Phosphorylation	RQDSRYYSDREKHRK HCCCCCCCCHHHHHC	22.66	-
1619	Phosphorylation	RSREHRPSLEGGLKD CCCCCCCCCCCCCCC	38.72	26824392
1648	Phosphorylation	HSDHRSSSEHTHHKS CCCCCCCCCCCCCCC	34.34	25266776
1661	Phosphorylation	KSSRDYRYLSDWQLD CCCCCCHHCCHHHCC	12.34	28066266
1663	Phosphorylation	SRDYRYLSDWQLDHR CCCCHHCCHHHCCHH	28.06	26745281
1673	Phosphorylation	QLDHRAASSGPRSPL HCCHHHHCCCCCCCC	34.54	27149854
1674	Phosphorylation	LDHRAASSGPRSPLD CCHHHHCCCCCCCCC	48.35	27149854
1678	Phosphorylation	AASSGPRSPLDQRSP HHCCCCCCCCCCCCC	32.71	25521595
1684	Phosphorylation	RSPLDQRSPYGSRSP CCCCCCCCCCCCCCC	19.48	23684622
1686	Phosphorylation	PLDQRSPYGSRSPFE CCCCCCCCCCCCCCC	29.04	26643407
1688	Phosphorylation	DQRSPYGSRSPFEHS CCCCCCCCCCCCCCC	24.60	26824392
1690	Phosphorylation	RSPYGSRSPFEHSAE CCCCCCCCCCCCCCC	35.32	23684622
1695	Phosphorylation	SRSPFEHSAEHRSTP CCCCCCCCCCCCCCC	28.31	26643407
1700	Phosphorylation	EHSAEHRSTPEHTWS CCCCCCCCCCCCCCC	50.66	26643407
1701	Phosphorylation	HSAEHRSTPEHTWSS CCCCCCCCCCCCCCC	32.43	26643407
1705	Phosphorylation	HRSTPEHTWSSRKT- CCCCCCCCCCCCCC-	25.94	26643407
1707	Phosphorylation	STPEHTWSSRKT--- CCCCCCCCCCCC---	22.78	26643407
1708	Phosphorylation	TPEHTWSSRKT---- CCCCCCCCCCC----	29.38	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSRP1_HUMAN	SSRP1	physical	10199952

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, AND MASSSPECTROMETRY.
PubMed: 17242355