dbPTM

CF132_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CF132_HUMAN
UniProt AC	Q5T0Z8
Protein Name	Uncharacterized protein C6orf132
Gene Name	C6orf132
Organism	Homo sapiens (Human).
Sequence Length	1188
Subcellular Localization
Protein Description
Protein Sequence	MKKKQTVQGTFSKLFGKKHTTTPSTSLYATNPPWIFTQEAPEEGTGGFDGIYYGDNRFNTVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTTRYGSPINTFTVRPGTRHPISYVCSGAHRKATS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KKQTVQGTFSKLFGK CCCCCCCHHHHHHCC	13.98	24719451
20	Phosphorylation	KLFGKKHTTTPSTSL HHHCCCCCCCCCCCE	41.04	27642862
22	Phosphorylation	FGKKHTTTPSTSLYA HCCCCCCCCCCCEEE	19.19	-
24	Phosphorylation	KKHTTTPSTSLYATN CCCCCCCCCCEEECC	28.65	27642862
25	Phosphorylation	KHTTTPSTSLYATNP CCCCCCCCCEEECCC	24.77	27642862
26	Phosphorylation	HTTTPSTSLYATNPP CCCCCCCCEEECCCC	24.58	27642862
28	Phosphorylation	TTPSTSLYATNPPWI CCCCCCEEECCCCEE	15.90	27642862
30	Phosphorylation	PSTSLYATNPPWIFT CCCCEEECCCCEEEE	34.40	27642862
37	Phosphorylation	TNPPWIFTQEAPEEG CCCCEEEEECCCCCC	19.16	27259358
45	Phosphorylation	QEAPEEGTGGFDGIY ECCCCCCCCCCCCEE	37.09	-
52	Phosphorylation	TGGFDGIYYGDNRFN CCCCCCEEECCCCCE	13.61	20736484
53	Phosphorylation	GGFDGIYYGDNRFNT CCCCCEEECCCCCEE	18.97	27642862
60	Phosphorylation	YGDNRFNTVSESGTA ECCCCCEEECCCCCC	23.77	27251275
62	Phosphorylation	DNRFNTVSESGTATL CCCCEEECCCCCCEE	24.81	27251275
64	Phosphorylation	RFNTVSESGTATLKA CCEEECCCCCCEECC	33.66	25404012
66	Phosphorylation	NTVSESGTATLKARP EEECCCCCCEECCCC	26.25	27251275
68	Phosphorylation	VSESGTATLKARPRV ECCCCCCEECCCCCC	28.73	27050516
98	Phosphorylation	GLAVPTPSVPDDFAD CCCCCCCCCCCCCCC	49.08	28348404
109	Phosphorylation	DFADKEVTGTSSLVN CCCCCCCCCCHHHHC	35.51	-
122	Phosphorylation	VNGNLRLYSSVGDLR HCCCEEEEEECCCCC	7.77	27642862
241	Phosphorylation	PAPPAPASPHTVGTR CCCCCCCCCCCCCCC	19.02	26657352
247	Phosphorylation	ASPHTVGTRLFPPGG CCCCCCCCCEECCCC	21.62	20058876
256	Phosphorylation	LFPPGGVTKWKSDVA EECCCCCCEEECCEE	34.17	20058876
260	Phosphorylation	GGVTKWKSDVALNGR CCCCEEECCEEECCC	35.88	28188228
272	Phosphorylation	NGRQAEATRASPPRS CCCCCCCCCCCCCCC	20.48	28188228
275	Phosphorylation	QAEATRASPPRSPAE CCCCCCCCCCCCCCC	31.95	27794612
279	Phosphorylation	TRASPPRSPAEPKGS CCCCCCCCCCCCCCC	33.95	26657352
297	Phosphorylation	PNPEPHLTFPRSFKV CCCCCCCCCCCCCCC	28.67	25056879
301	Phosphorylation	PHLTFPRSFKVPPPT CCCCCCCCCCCCCCC	29.65	24719451
308	Phosphorylation	SFKVPPPTPVRTSSI CCCCCCCCCCCCCCC	39.94	24719451
312	Phosphorylation	PPPTPVRTSSIPVQE CCCCCCCCCCCCHHH	27.36	23312004
313	Phosphorylation	PPTPVRTSSIPVQEA CCCCCCCCCCCHHHH	18.73	26657352
314	Phosphorylation	PTPVRTSSIPVQEAQ CCCCCCCCCCHHHHH	30.23	26657352
369	Phosphorylation	CPGELKATAPASPRL CCCCCCCCCCCCCCC	31.42	23312004
373	Phosphorylation	LKATAPASPRLGQSQ CCCCCCCCCCCCCCH	14.97	28985074
379	Phosphorylation	ASPRLGQSQSQADER CCCCCCCCHHHHHHH	29.96	27794612
381	Phosphorylation	PRLGQSQSQADERAG CCCCCCHHHHHHHCC	32.36	27794612
389	Phosphorylation	QADERAGTPPPAPPL HHHHHCCCCCCCCCC	31.47	26657352
431	Phosphorylation	AHPPAGFTKTPKSSS CCCCCCCCCCCCCCC	32.84	24719451
436	Phosphorylation	GFTKTPKSSSPALKP CCCCCCCCCCCCCCC	36.93	23312004
437	Phosphorylation	FTKTPKSSSPALKPK CCCCCCCCCCCCCCC	46.60	26657352
438	Phosphorylation	TKTPKSSSPALKPKP CCCCCCCCCCCCCCC	22.68	26657352
449	Phosphorylation	KPKPNPPSPENTASS CCCCCCCCCCCCCCC	46.21	26657352
453	Phosphorylation	NPPSPENTASSAPVD CCCCCCCCCCCCCCC	26.67	23312004
455	Phosphorylation	PSPENTASSAPVDWR CCCCCCCCCCCCCCC	25.62	23312004
456	Phosphorylation	SPENTASSAPVDWRD CCCCCCCCCCCCCCC	33.84	28102081
477	Phosphorylation	LRNELAAYLCGSRRE HHHHHHHHHHCCCCH	9.27	23403867
481	Phosphorylation	LAAYLCGSRREDRFL HHHHHHCCCCHHCHH	27.45	23403867
517	Phosphorylation	PEKETLLSLPAKDTP CCCCEEECCCCCCCC	35.11	26270265
523	Phosphorylation	LSLPAKDTPPGVPEK ECCCCCCCCCCCCCC	30.58	21815630
531	Phosphorylation	PPGVPEKSLGGSSLT CCCCCCCCCCCCCCC	30.50	28961369
535	Phosphorylation	PEKSLGGSSLTETEA CCCCCCCCCCCCCCC	22.00	28961369
553	Phosphorylation	LTLPSVDYIPQDSPT CCCCCCCCCCCCCCC	16.61	26657352
558	Phosphorylation	VDYIPQDSPTPSVRQ CCCCCCCCCCHHHHH	25.98	28188228
575	Phosphorylation	NELEARLSSAAEKEA HHHHHHHHHHHHHHC	16.63	26657352
583	"N6,N6-dimethyllysine"	SAAEKEAKPSIGSLP HHHHHHCCCCCCCCC	40.15	-
583	Methylation	SAAEKEAKPSIGSLP HHHHHHCCCCCCCCC	40.15	23644510
588	Phosphorylation	EAKPSIGSLPPKPRL HCCCCCCCCCCCCCC	35.71	30576142
646	Phosphorylation	PAIPPKATPEPAIPP CCCCCCCCCCCCCCC	34.02	28674419
656	Phosphorylation	PAIPPKATLWPATPP CCCCCCCCCCCCCCC	35.17	23312004
661	Phosphorylation	KATLWPATPPKATLG CCCCCCCCCCCCCCC	35.72	19664994
666	Phosphorylation	PATPPKATLGPATPL CCCCCCCCCCCCCCC	38.07	20068231
671	Phosphorylation	KATLGPATPLKATSG CCCCCCCCCCCCCCC	32.08	28985074
674	Methylation	LGPATPLKATSGPTT CCCCCCCCCCCCCCC	51.31	-
676	Phosphorylation	PATPLKATSGPTTPL CCCCCCCCCCCCCCC	32.40	23090842
677	Phosphorylation	ATPLKATSGPTTPLK CCCCCCCCCCCCCCC	47.86	25056879
680	Phosphorylation	LKATSGPTTPLKATS CCCCCCCCCCCCCCC	44.57	23090842
681	Phosphorylation	KATSGPTTPLKATSG CCCCCCCCCCCCCCC	29.74	25056879
684	Methylation	SGPTTPLKATSGPAI CCCCCCCCCCCCCCC	51.31	-
696	Phosphorylation	PAIASTATTLPTTTS CCCCCCCCCCCCCHH	29.02	-
711	Phosphorylation	QLMAEKDSGPAGQPE HHHHHHCCCCCCCCC	58.71	23312004
722	Phosphorylation	GQPEKPASQEVSTPS CCCCCCCCCCCCCHH	35.09	23312004
726	Phosphorylation	KPASQEVSTPSQARG CCCCCCCCCHHHHCC	33.57	23312004
727	Phosphorylation	PASQEVSTPSQARGE CCCCCCCCHHHHCCC	31.94	29496963
729	Phosphorylation	SQEVSTPSQARGEGS CCCCCCHHHHCCCCC	36.24	23312004
736	Phosphorylation	SQARGEGSPSEATRL HHHCCCCCHHHHHCC	22.43	30266825
738	Phosphorylation	ARGEGSPSEATRLPT HCCCCCHHHHHCCCC	41.37	30266825
741	Phosphorylation	EGSPSEATRLPTQGA CCCHHHHHCCCCCCC	28.78	30266825
745	Phosphorylation	SEATRLPTQGARSSA HHHHCCCCCCCCCCC	44.20	30266825
758	Phosphorylation	SAAFPPKTSPGGGEV CCCCCCCCCCCCCCC	46.02	25056879
759	Phosphorylation	AAFPPKTSPGGGEVP CCCCCCCCCCCCCCC	27.89	25056879
776	Phosphorylation	YKPHCHQSSLSREVA CCCCCCCCCCCHHHH	15.02	24719451
777	Phosphorylation	KPHCHQSSLSREVAV CCCCCCCCCCHHHHH	24.64	28348404
779	Phosphorylation	HCHQSSLSREVAVVM CCCCCCCCHHHHHHH	28.48	28348404
829	Phosphorylation	ELLRHPVTGEVVERG HHHHCCCCCCHHHCC	31.88	-
837	Phosphorylation	GEVVERGSPMALLLA CCHHHCCCHHHHHHH	20.09	20068231
854	Phosphorylation	QRAQKGRSVGAALGR HHHHHCCCHHHHHCC	33.30	23312004
862	Phosphorylation	VGAALGRSSLPGSLR HHHHHCCCCCCCCCC	34.13	28348404
863	Phosphorylation	GAALGRSSLPGSLRD HHHHCCCCCCCCCCC	36.90	23312004
867	Phosphorylation	GRSSLPGSLRDHSHQ CCCCCCCCCCCCCCC	20.49	28060719
872	Phosphorylation	PGSLRDHSHQAEASS CCCCCCCCCCCCCCC	22.91	28348404
878	Phosphorylation	HSHQAEASSDSIFHS CCCCCCCCCCCCCCC	26.61	28348404
879	Phosphorylation	SHQAEASSDSIFHSQ CCCCCCCCCCCCCCC	42.28	28348404
881	Phosphorylation	QAEASSDSIFHSQGT CCCCCCCCCCCCCCC	29.15	28348404
885	Phosphorylation	SSDSIFHSQGTPNSF CCCCCCCCCCCCCCE	21.40	28348404
888	Phosphorylation	SIFHSQGTPNSFTVV CCCCCCCCCCCEEEC	16.20	28348404
906	Phosphorylation	PKEAEKDSPLTTEIP CCHHCCCCCCCCCCC	32.64	26657352
909	Phosphorylation	AEKDSPLTTEIPNKW HCCCCCCCCCCCCCC	26.26	27794612
910	Phosphorylation	EKDSPLTTEIPNKWG CCCCCCCCCCCCCCC	39.33	27794612
930	Phosphorylation	DAEGTELSRRHNWTK CCCCCCCHHHCCCCC	22.49	23532336
963	Phosphorylation	QGHPLPKSFSSPPSP CCCCCCCCCCCCCCC	28.55	23927012
965	Phosphorylation	HPLPKSFSSPPSPSN CCCCCCCCCCCCCCC	49.37	25849741
966	Phosphorylation	PLPKSFSSPPSPSNK CCCCCCCCCCCCCCC	38.53	26657352
969	Phosphorylation	KSFSSPPSPSNKREE CCCCCCCCCCCCCHH	44.32	28355574
971	Phosphorylation	FSSPPSPSNKREEEE CCCCCCCCCCCHHHH	60.36	25849741
1010	Phosphorylation	LQYLGRQSSPPRNNY HHHHCCCCCCCCCCH	43.37	28152594
1011	Phosphorylation	QYLGRQSSPPRNNYS HHHCCCCCCCCCCHH	30.50	28355574
1017	Phosphorylation	SSPPRNNYSDLRQLP CCCCCCCHHHHHHCC	13.70	28152594
1018	Phosphorylation	SPPRNNYSDLRQLPN CCCCCCHHHHHHCCC	32.09	28152594
1037	Phosphorylation	APPALGFSRFPAGAR CCCCCCCCCCCCCCC	31.08	21060948
1044	Asymmetric dimethylarginine	SRFPAGARYAGAGGL CCCCCCCCCCCCCCC	22.40	-
1044	Methylation	SRFPAGARYAGAGGL CCCCCCCCCCCCCCC	22.40	24129315
1045	Phosphorylation	RFPAGARYAGAGGLE CCCCCCCCCCCCCCC	14.62	-
1055	Phosphorylation	AGGLERFSGGGRSLI CCCCCCCCCCCCHHH	42.63	27251275
1060	Phosphorylation	RFSGGGRSLIKKRLY CCCCCCCHHHEEEEE	37.41	25106551
1067	Phosphorylation	SLIKKRLYVGEPHRG HHHEEEEECCCCCCC	15.50	28152594
1073	Methylation	LYVGEPHRGPGLPHG EECCCCCCCCCCCCC	64.81	24129315
1084	Methylation	LPHGGTGRSLSSPNC CCCCCCCCCCCCCCC	33.97	24129315
1085	Phosphorylation	PHGGTGRSLSSPNCF CCCCCCCCCCCCCCC	33.67	23090842
1087	Phosphorylation	GGTGRSLSSPNCFGP CCCCCCCCCCCCCCC	45.02	25394399
1088	Phosphorylation	GTGRSLSSPNCFGPQ CCCCCCCCCCCCCCC	25.98	26657352
1106	Phosphorylation	PEMRRVNSAGRAPPG HHHHCCCCCCCCCCC	29.28	25394399
1119	Dimethylation	PGGLHAPRLSLEGAA CCCCCCCCCCHHHHH	37.38	-
1119	Methylation	PGGLHAPRLSLEGAA CCCCCCCCCCHHHHH	37.38	-
1121	Phosphorylation	GLHAPRLSLEGAARG CCCCCCCCHHHHHHC	26.17	27794612
1127	Dimethylation	LSLEGAARGAAEAKH CCHHHHHHCHHHHHH	34.45	-
1127	Methylation	LSLEGAARGAAEAKH CCHHHHHHCHHHHHH	34.45	-
1139	Phosphorylation	AKHKAPGSADYGFAP HHHCCCCCCCCCCCC	19.53	22617229
1142	Phosphorylation	KAPGSADYGFAPAAG CCCCCCCCCCCCCCC	17.54	20007894
1151	Phosphorylation	FAPAAGRSPYTTTRY CCCCCCCCCCCCCCC	22.72	24719451
1153	Phosphorylation	PAAGRSPYTTTRYGS CCCCCCCCCCCCCCC	20.26	28152594
1154	Phosphorylation	AAGRSPYTTTRYGSP CCCCCCCCCCCCCCC	25.69	28152594
1157	Asymmetric dimethylarginine	RSPYTTTRYGSPINT CCCCCCCCCCCCCCE	31.55	-
1157	Methylation	RSPYTTTRYGSPINT CCCCCCCCCCCCCCE	31.55	24129315
1158	Phosphorylation	SPYTTTRYGSPINTF CCCCCCCCCCCCCEE	21.62	28152594
1160	Phosphorylation	YTTTRYGSPINTFTV CCCCCCCCCCCEEEE	17.42	28152594
1164	Phosphorylation	RYGSPINTFTVRPGT CCCCCCCEEEECCCC	22.77	27794612
1166	Phosphorylation	GSPINTFTVRPGTRH CCCCCEEEECCCCCC	17.36	27794612
1168	Dimethylation	PINTFTVRPGTRHPI CCCEEEECCCCCCCC	22.37	-
1168	Methylation	PINTFTVRPGTRHPI CCCEEEECCCCCCCC	22.37	-
1171	Phosphorylation	TFTVRPGTRHPISYV EEEECCCCCCCCEEE	28.61	27794612
1176	Phosphorylation	PGTRHPISYVCSGAH CCCCCCCEEECCCCC	18.90	26356563
1177	Phosphorylation	GTRHPISYVCSGAHR CCCCCCEEECCCCCC	13.24	26356563

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CF132_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CF132_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CF132_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CF132_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CF132_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1142, AND MASSSPECTROMETRY.	19534553 [Abstract]