CERS4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CERS4_MOUSE
• UniProt AC: Q9D6J1
• Protein Name: Ceramide synthase 4
• Gene Name: Cers4
• Organism: Mus musculus (Mouse).
• Sequence Length: 393
• Subcellular Localization: Nucleus membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner..
• Protein Sequence: MSFSLSEWLWQETYWLPPNVTWAELEDRDGLVFAHPHHVLAAFPVALVLVAVRIVFERFVALPLSRWMGVQDPIRRKIKPNPVLEKYFLRMKQCPEETQMVLLASQCGLTLRQTQRWFRRRRNQDRPSLSKKFCEACWRFVFYLCSFVGGTSILYHESWLWSPSLCWENYPHQTLNLSLYWWYLLELGFYLSLLITLPFDVKRKDFKEQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRGCDALFIMFALVFFYTRLIFFPTQVIYTSVYDSIKNSGPFFGYYFFIVLLVMLQILHVYWFCLILRMLYSFLHKGQMTEDIRSDVEEPDSSDDEPVSEGPQLKNGMARGSRVAVTNGPRSRAAACLTNGHTRAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	N-linked_Glycosylation	ETYWLPPNVTWAELE HHCCCCCCCEEEEEE	41.74	-
337	Phosphorylation	FLHKGQMTEDIRSDV HHHCCCCCHHHHHCC	23.71	24704852
342	Phosphorylation	QMTEDIRSDVEEPDS CCCHHHHHCCCCCCC	46.47	21082442
349	Phosphorylation	SDVEEPDSSDDEPVS HCCCCCCCCCCCCCC	46.51	21082442
350	Phosphorylation	DVEEPDSSDDEPVSE CCCCCCCCCCCCCCC	57.36	21082442
356	Phosphorylation	SSDDEPVSEGPQLKN CCCCCCCCCCHHHCC	47.77	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CERS4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CERS4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CERS4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CERS4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349 AND SER-350, ANDMASS SPECTROMETRY.
PubMed: 19367708