CEP57_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CEP57_MOUSE
• UniProt AC: Q8CEE0
• Protein Name: Centrosomal protein of 57 kDa
• Gene Name: Cep57
• Organism: Mus musculus (Mouse).
• Sequence Length: 500
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
• Protein Description: Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2..
• Protein Sequence: MAAASVSAASDSQFSSVLAEPSRSNGNMVRHSSSPYVLYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELASQLVAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTAMQALAEKKMQELESKLREEEQERKRMQARAAELQSGLEANRLIFEDKTTSCVSTSTRKIKKKKSKPPEKKGSRTYFGAQPHYRLCLGDMPFVAGTSTSPSHAVVANVQHVLHLMKHHSKALCNDRVVNSVPLAKQACSRVSKSKKSVVPPSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQNIDKQKKELKANKKTLDEEGNSSGRSSGVPRTASKKDLAKQRPGEKSRKNLQLLKDMQTIQNSLQSSNLCWDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	AASDSQFSSVLAEPS CCCCCCHHHHHCCCC	16.35	29514104
16	Phosphorylation	ASDSQFSSVLAEPSR CCCCCHHHHHCCCCC	23.57	29514104
34	Phosphorylation	NMVRHSSSPYVLYPP CCCCCCCCCEEECCC	24.22	-
36	Phosphorylation	VRHSSSPYVLYPPDK CCCCCCCEEECCCCC	12.68	29514104
53	Phosphorylation	LNSDLRRSPNKPTFA CCCCCCCCCCCCCCC	26.79	22817900
58	Phosphorylation	RRSPNKPTFAYPESN CCCCCCCCCCCCCHH	23.62	25168779
61	Phosphorylation	PNKPTFAYPESNSRA CCCCCCCCCCHHHHH	11.89	25168779
387	Phosphorylation	LTKLIQESPTVELKD HHHHHHHCCCEEECC	14.97	28066266
389	Phosphorylation	KLIQESPTVELKDNL HHHHHCCCEEECCCH	35.57	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CEP57_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CEP57_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CEP57_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CEP57_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.