CE162_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CE162_RAT
• UniProt AC: Q4KLH6
• Protein Name: Centrosomal protein of 162 kDa
• Gene Name: Cep162
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1403
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle . Nucleus. Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to
• Protein Description: Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity)..
• Protein Sequence: MAHYSKVDLDEEFERFMKELSDDSFENSNETPSQPNKDRKKKDTAPWWIAEDGFEDDGLLGTNVSYLKTKKTYQPITDMEEENEKVQFLKSSGTSVLSVDSLEANELVASELHHSTLGLGLDTLEEQEEKEQFFARLEKGLTSSIDYSKLNQELDSDDSAQFRVLHRYQGNVEPAEGGRENESEHKELPETYSDDFEDAEDTDEPLITKDEETRPKENPESGKGSFPNQEEEKTGMLANVVLLDSFDSVEDVDLNNHERPTPKAKALPEMAGGELAETGVSYGQSSGDTEALHQAYHHVAHSLGDTGEPRIEASPGHSVRSSAKDGLQENEESSKNISTTESDLPTVEELMKPIRIDSYGIRGFDLQPVSLQKAVGSKEAESVSSLPLTVNTNTMSQDTRHVSPFPHEQDESVVLHRTAGEGVGSSCPATEEHLDKMYLEILRKKTSVNPSLLPQDNKANQTSRSRLSAREEAPVTSKQVPCKKARSAPPLPRRKPQSGLYASARSSGYSKPSSPLQFFSALEKKTSKDNTKTKNVRPIPTSNQFRKREILSGTKLIKPAALNKPSPHREGSPATPKRPEDPSDDSFVQLQTETLGSYGGNREKELLMLKRAQDAEEKWRGAQALIEQIKMTFSEKEKELENTVESLKRQQERELFKLNQENYILQAKLSSFEETSRKQRWLQFGETSDPLTEEKLKQIQKEIQEQETLLQGYQQENERLYSQVKDLQEQNKKNEERMFKENQNLFSELASLKEQMHKNHFLPQAVENIEPTKNQSFTDLLAELRAAQKEKNHLMEDIKRLKQDKQALEVDLERVKRERDQAKDQIAYTTGEKLYEIKILEETHKQEVSRLQKRLQWYAENQELLDKDAARLREANEETERLKLEIEKLKTESGSPANQQRLRSKERALDAKRIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDSVDRNTVDFMERRIKKLEADLEGKDEEAKKSLRTMEQQFQKMKIQYEQRLEEQEQMLAHRQREAPQNQHNSSSRLKALETELGGIKEAHQITVRKLEAEIDVLKHQNAHLEHKKNDKEDQDLQSIEFQVEQAQARAKLARLNEELAAKGREIQDLTKTVERLQKERRMMLSRQSPRGREEMAAKRLKKEILHPNSGNANAFSETLGAKLYHPHTFTDSHISEVLEENYRLRSELEGLTLEREKLKMESEAAVCQLESSMKRVKDDAAAHIASLKAAHEREIEKLLCQNAVENSSSRVAELNRKIATQEVLLKHFQGQVNELQGKQESLSLSQVREEILQKQITKLLEELKEAKENHTPEMKHFMGLERKIKQMEMRHKQREQELQQIIQQTRQVVETEQNKEVEKWKRLAQLKNRELDKFRTELDSILDVLRELHRQGVVVPVALADEESTAKEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	ERFMKELSDDSFENS HHHHHHHCCCCCCCC		28689409
24	Phosphorylation	MKELSDDSFENSNET HHHHCCCCCCCCCCC		28689409
156	Phosphorylation	KLNQELDSDDSAQFR HHHCCCCCCCCHHHH		27097102
159	Phosphorylation	QELDSDDSAQFRVLH CCCCCCCCHHHHHHH		27097102
468	Phosphorylation	QTSRSRLSAREEAPV HHHHHHHHHHHHCCC		-
520	Phosphorylation	SSPLQFFSALEKKTS CCHHHHHHHHHHHCC		22673903
802	Acetylation	MEDIKRLKQDKQALE HHHHHHHHHHHHHHH		26302492
805	Acetylation	IKRLKQDKQALEVDL HHHHHHHHHHHHHHH		26302492
893	Phosphorylation	IEKLKTESGSPANQQ HHHHHCCCCCHHHHH		27097102
895	Phosphorylation	KLKTESGSPANQQRL HHHCCCCCHHHHHHH		27097102
935	Phosphorylation	LKRRYPNSLPALILA HHHHCCCCHHHHHHH		26022182
944	Phosphorylation	PALILAASAAGDSVD HHHHHHHHHHCCCCC		26022182
949	Phosphorylation	AASAAGDSVDRNTVD HHHHHCCCCCHHHHH		26022182
954	Phosphorylation	GDSVDRNTVDFMERR CCCCCHHHHHHHHHH		26022182

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CE162_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CE162_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CE162_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CE162_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.