dbPTM

CDYL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDYL_MOUSE
UniProt AC	Q9WTK2
Protein Name	Chromodomain Y-like protein {ECO:0000303\|PubMed:10192397}
Gene Name	Cdyl {ECO:0000303\|PubMed:10192397, ECO:0000312\|MGI:MGI:1339956}
Organism	Mus musculus (Mouse).
Sequence Length	593
Subcellular Localization	Isoform 2: Nucleus . Chromosome . Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:24144980). Multimerization is requi
Protein Description	Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). [PubMed: 12947414 Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape]
Protein Sequence	MGIGNSQPNSQEAQLCTLPEKAEQPTDDNTCQQNNVVPATVSEPDQASPAIQDAETQVESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHNERQKEGSLARASRASPSNARKQISRSTHSTLSKTNSKALVVGKDHESKSSQLLAASQKFRKNPAPSLANRKNMDLAKSGIKILVPKSPVKGRTSVDGFQGESPEKLDPVDQGAEDTVAPEVTAEKPTGALLGPGAERARMGSRPRIHPLVPQVSGPVTAAMATGLAVNGKGTSPFMDALAANGTVTIQTSVTGVTAGKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMADAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLFSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	4.57	26643407
81	Phosphorylation	YLVRWKGYDSEDDTW EEEEECCCCCCCCCC	16.75	21149613
83	Phosphorylation	VRWKGYDSEDDTWEP EEECCCCCCCCCCCH	34.15	27087446
87	Phosphorylation	GYDSEDDTWEPEQHL CCCCCCCCCCHHHHE	44.01	21149613
121	Phosphorylation	EGSLARASRASPSNA HHHHHHHHHCCCCHH	23.87	29899451
124	Phosphorylation	LARASRASPSNARKQ HHHHHHCCCCHHHHH	27.96	25266776
126	Phosphorylation	RASRASPSNARKQIS HHHHCCCCHHHHHHH	40.40	29550500
130	Methylation	ASPSNARKQISRSTH CCCCHHHHHHHHHHC	49.96	-
130	"N6,N6,N6-trimethyllysine"	ASPSNARKQISRSTH CCCCHHHHHHHHHHC	49.96	-
133	Phosphorylation	SNARKQISRSTHSTL CHHHHHHHHHHCCCC	20.06	22802335
139	Phosphorylation	ISRSTHSTLSKTNSK HHHHHCCCCCCCCCC	27.70	22802335
159	Phosphorylation	KDHESKSSQLLAASQ CCCCCHHHHHHHHHH	28.69	21183079
165	Phosphorylation	SSQLLAASQKFRKNP HHHHHHHHHHHHHCC	28.44	21183079
175	Phosphorylation	FRKNPAPSLANRKNM HHHCCCHHHHCCCCH	42.07	-
187	Phosphorylation	KNMDLAKSGIKILVP CCHHHHHCCCEEEEE	39.89	19144319
196	Phosphorylation	IKILVPKSPVKGRTS CEEEEECCCCCCCCC	28.93	26824392
202	Phosphorylation	KSPVKGRTSVDGFQG CCCCCCCCCCCCCCC	41.59	23684622
203	Phosphorylation	SPVKGRTSVDGFQGE CCCCCCCCCCCCCCC	19.49	25521595
211	Phosphorylation	VDGFQGESPEKLDPV CCCCCCCCHHHCCCC	45.22	25521595
225	Phosphorylation	VDQGAEDTVAPEVTA CCCCCCCCCCCCCCC	15.29	25159016
326	Phosphorylation	FDKRLRFSVRQTESA CCHHHCCEEECCCCH	15.23	28725479

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDYL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDYL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDYL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CDYL_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDYL_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187 AND SER-196, ANDMASS SPECTROMETRY.	19144319 [Abstract]