CDPKR_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDPKR_ARATH
• UniProt AC: Q9ZSA4
• Protein Name: Calcium-dependent protein kinase 27
• Gene Name: CPK27
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 485
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Description: May play a role in signal transduction pathways that involve calcium as a second messenger..
• Protein Sequence: MGCFSSKELQQSKRTILEKPLVDITKIYILGEELGRGNFGLTRKCVEKSTGKTFACKTILKTKLKDEECEEDVKREIRIMKQLSGEPNIVEFKNAYEDKDSVHIVMEYCGGGELYDKILALYDVGKSYSEKEAAGIIRSIVNVVKNCHYMGVMHRDLKPENFLLTSNDDNATVKVIDFGCSVFIEEGKVYQDLAGSDYYIAPEVLQGNYGKEADIWSAGIILYILLCGKSPFVKEPEGQMFNEIKSLEIDYSEEPWPLRDSRAIHLVKRMLDRNPKERISAAEVLGHPWMKEGEASDKPIDGVVLSRLKRFRDANKFKKVVLKFIAANLSEEEIKGLKTLFTNIDTDKSGNITLEELKTGLTRLGSNLSKTEVEQLMEAADMDGNGTIDIDEFISATMHRYKLDRDEHVYKAFQHFDKDNDGHITKEELEMAMKEDGAGDEGSIKQIIADADTDNDGKINFEEFRTMMRTESSLQPEGELLPIIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCFSSKEL ------CCCCCHHHH	22.60	-
42	Phosphorylation	GRGNFGLTRKCVEKS CCCCCCCCHHHHHHC	28.58	19880383
196	Phosphorylation	VYQDLAGSDYYIAPE EEHHHCCCCEEECHH	19.48	-
230	Phosphorylation	YILLCGKSPFVKEPE HHHHHCCCCCCCCCC	14.62	19880383
470	Phosphorylation	EFRTMMRTESSLQPE HHHHHHHCCCCCCCC	23.48	23776212
472	Phosphorylation	RTMMRTESSLQPEGE HHHHHCCCCCCCCCC	35.42	23776212
473	Phosphorylation	TMMRTESSLQPEGEL HHHHCCCCCCCCCCC	25.45	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDPKR_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDPKR_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDPKR_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CDPKR_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472, AND MASSSPECTROMETRY.
PubMed: 18433157