CDPKL_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDPKL_ARATH
• UniProt AC: Q9ZSA2
• Protein Name: Calcium-dependent protein kinase 21
• Gene Name: CPK21
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 531
• Subcellular Localization: Cell membrane ; Lipid-anchor .
• Protein Description: May play a role in signal transduction pathways that involve calcium as a second messenger. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1..
• Protein Sequence: MGCFSSKHRKTQNDGGEKSIPINPVQTHVVPEHRKPQTPTPKPMTQPIHQQISTPSSNPVSVRDPDTILGKPFEDIRKFYSLGKELGRGQFGITYMCKEIGTGNTYACKSILKRKLISKQDKEDVKREIQIMQYLSGQPNIVEIKGAYEDRQSIHLVMELCAGGELFDRIIAQGHYSERAAAGIIRSIVNVVQICHFMGVVHRDLKPENFLLSSKEENAMLKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLRRSYGKEIDIWSAGVILYILLSGVPPFWAENEKGIFDEVIKGEIDFVSEPWPSISESAKDLVRKMLTKDPKRRITAAQVLEHPWIKGGEAPDKPIDSAVLSRMKQFRAMNKLKKLALKVIAESLSEEEIKGLKTMFANIDTDKSGTITYEELKTGLTRLGSRLSETEVKQLMEAADVDGNGTIDYYEFISATMHRYKLDRDEHVYKAFQHFDKDNSGHITRDELESAMKEYGMGDEASIKEVISEVDTDNDGRINFEEFCAMMRSGSTQPQGKLLPFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCFSSKHR ------CCCCCCCCC	22.60	-
19	Phosphorylation	QNDGGEKSIPINPVQ CCCCCCCCCCCCCCE	29.33	27288362
27	Phosphorylation	IPINPVQTHVVPEHR CCCCCCEECCCCCCC	19.51	23111157
38	Phosphorylation	PEHRKPQTPTPKPMT CCCCCCCCCCCCCCC	37.34	25561503
244	Phosphorylation	VYRDIVGSAYYVAPE EEEHHCCHHHHHCHH	11.38	15308754
376	Phosphorylation	ALKVIAESLSEEEIK HHHHHHHHCCHHHHC	28.33	17317660
417	Phosphorylation	TRLGSRLSETEVKQL HHHHHCCCHHHHHHH	41.17	25561503
419	Phosphorylation	LGSRLSETEVKQLME HHHCCCHHHHHHHHH	42.58	25561503
469	Phosphorylation	QHFDKDNSGHITRDE HHHCCCCCCCCCHHH	41.71	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDPKL_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDPKL_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDPKL_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P2C56_ARATH	ABI1	physical	20385816

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
PubMed: 14506206