CDK17_MOUSE - dbPTM
CDK17_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDK17_MOUSE
UniProt AC Q8K0D0
Protein Name Cyclin-dependent kinase 17
Gene Name Cdk17
Organism Mus musculus (Mouse).
Sequence Length 523
Subcellular Localization
Protein Description May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity)..
Protein Sequence MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEESSSKDNEPIVKNGRPPTSHSVHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQISSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVPAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSMLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationKKFKRRLSLTLRGSQ
CHHHHHHHHHHCCCH		19.9326824392
11PhosphorylationFKRRLSLTLRGSQTI
HHHHHHHHHCCCHHH		15.8425619855
15PhosphorylationLSLTLRGSQTIDESL
HHHHHCCCHHHHHHH		20.0929899451
50PhosphorylationVKNGRPPTSHSVHSF
CCCCCCCCCCCHHHH		41.5829899451
51PhosphorylationKNGRPPTSHSVHSFL
CCCCCCCCCCHHHHH		21.3821183079
53PhosphorylationGRPPTSHSVHSFLHQ
CCCCCCCCHHHHHHH		22.6922807455
75PhosphorylationPPLRRPHSVIGGSLG
CCCCCCCCEECCCHH		20.3626824392
80PhosphorylationPHSVIGGSLGSFMAM
CCCEECCCHHHHHCC		25.0929899451
92PhosphorylationMAMPRNGSRLDIVHE
HCCCCCCCCCEEEEC		32.9725521595
105PhosphorylationHENLKMGSDGESDQA
ECCCCCCCCCCCCCC		38.6625619855
109PhosphorylationKMGSDGESDQASGTS
CCCCCCCCCCCCCCC		40.3225619855
113PhosphorylationDGESDQASGTSSDEV
CCCCCCCCCCCCCCC		36.6525619855
115PhosphorylationESDQASGTSSDEVQS
CCCCCCCCCCCCCCC		23.6725619855
116PhosphorylationSDQASGTSSDEVQSP
CCCCCCCCCCCCCCC		39.0425619855
117PhosphorylationDQASGTSSDEVQSPT
CCCCCCCCCCCCCCC		37.3125619855
122PhosphorylationTSSDEVQSPTGVCLR
CCCCCCCCCCCCHHH		29.6125521595
124PhosphorylationSDEVQSPTGVCLRNR
CCCCCCCCCCHHHHH		47.7125619855
137PhosphorylationNRIHRRISMEDLNKR
HHHHCCCCHHHHHHH		17.8227087446
146PhosphorylationEDLNKRLSLPADIRI
HHHHHHHCCCCCCCC		36.0226824392
157PhosphorylationDIRIPDGYLEKLQIS
CCCCCCCHHHHCCCC		21.0429514104
164PhosphorylationYLEKLQISSPPFDQP
HHHHCCCCCCCCCCC		24.6723527152
165PhosphorylationLEKLQISSPPFDQPM
HHHCCCCCCCCCCCC		37.9227087446
173PhosphorylationPPFDQPMSRRSRRAS
CCCCCCCCHHHHCCC		31.0928833060
176PhosphorylationDQPMSRRSRRASLSE
CCCCCHHHHCCCHHH		25.6329514104
180PhosphorylationSRRSRRASLSEIGFG
CHHHHCCCHHHHCCC		30.5327087446
182PhosphorylationRSRRASLSEIGFGKM
HHHCCCHHHHCCCHH		25.3625168779
191PhosphorylationIGFGKMETYIKLEKL
HCCCHHHEEEEEEEC		27.3530482847
202PhosphorylationLEKLGEGTYATVYKG
EEECCCCEEEEEEEC		12.9922322096
203PhosphorylationEKLGEGTYATVYKGR
EECCCCEEEEEEECC		15.9022322096
205PhosphorylationLGEGTYATVYKGRSK
CCCCEEEEEEECCCH		17.6022499769
207PhosphorylationEGTYATVYKGRSKLT
CCEEEEEEECCCHHH		11.9022499769
221UbiquitinationTENLVALKEIRLEHE
HHHHHHHHHHHCCCC		41.16-
234PhosphorylationHEEGAPCTAIREVSL
CCCCCCCCHHHHHHH		24.8618779572
240PhosphorylationCTAIREVSLLKDLKH
CCHHHHHHHHHHHHC		24.1918779572
243UbiquitinationIREVSLLKDLKHANI
HHHHHHHHHHHCCCE		67.33-
315UbiquitinationKVLHRDLKPQNLLIN
CHHCCCCCHHCEEEC		49.17-
328UbiquitinationINERGELKLADFGLA
ECCCCCEEEHHHCCC		37.01-
520PhosphorylationHGKNRRQSMLF----
CCCCCCCCCCC----		18.6823737553
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDK17_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDK17_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDK17_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CDK17_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDK17_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-137 AND SER-180,AND MASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-146 ANDSER-180, AND MASS SPECTROMETRY.
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-203, AND MASSSPECTROMETRY.

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