CDGAP_DROME - dbPTM
CDGAP_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDGAP_DROME
UniProt AC Q9VIS1
Protein Name GTPase-activating protein CdGAPr
Gene Name CdGAPr
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1843
Subcellular Localization
Protein Description Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation..
Protein Sequence MSDKVSTSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAISAQLNFKIVPADSLPGLSYQDMFASMNTSQISNASTESSCSPPIQGAVPPPKPSRHMAVQPLNSKSCRFPKLEECAHFHYERVQLGPLSVQLLDDKSEHMGSSIASQSLGGDLPHSSLRSFSPESCWFIIRVCPQRCEPFLIKRSFENMQLLDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERFSKIASDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISVIDMPSPAESIWWRGKKSHLQKSLYEVGFFPQSCVATIGDKVPRNFPMPAPLVGHLDASPTKPVLRKHGKLIAFFRSFILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVIDGIYRLSGITSNIQRLRRAFDEERVPDLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGVGVQAVVTEYLIRNCHNIFDALDDHPARHSMVASATAAAANAAGGELRLESLTDCESLLVEQREQDQSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNIGSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSVASRVSFVQASHAHASKELTKHDKPKSIELLETTSNERDPKPMDLCIRSNSIDSLRTVGHSRSVSHDSYFDLLQSPQRGHMTTCPSRELSELGLNFDREEPEMRIFSESESLVSSPRVGKENVPPASGSATRRIMRARPEDFSSQTNSVNPSPKKQPRLNLLSPSSARTMPPPPLSAPGTASSSCGHESGGAENCCKRYKLEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSSNGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQKQESSAPRPVHSTNNGATLRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGVSGVSSNVQQQQLLLGVDASSSYLGSSHESLGQNINNHHDAEQRDMNALKRELSLDLNPLQPRLPQPANRAATLPVKDQLQAAAAAMCSSPNNSNFTDNTSQSVTPSEYGYQHLQRQLSMHSLLATDESSPVYEDFEQTPVKMVPSPIKSTISITYKSPEKEKKPSAILETNFDENTVYEQVKLFRNSVTEVNQMLHERSSLKQIAEEEQHDGGAYKAAEMTQQLLQLEQEHHDHEEQQEKEPEDEEQSQLLYENIELRKPKTVYENLRGEEMKFITEEQKPNVDRIELDSLDSLPDNMEHEQSSPSKSPTFSVKELANKFESSPVEQLPNFDFSVRGGSMKKPNELSVPKTMPAPVPLKKLNSSAQKITRSLDENAFVREFGGKQLQDLSLSNKLPEVMSEVNSRRKSFDFTRPKTLNPPKRLPGMSITEEICQKRVGEMEAITPTTENRISLIQQNNMPKEQQSSANQFLPPAGRKNVLTGVVLDRERIDKIKEERRQQLTQKYYGDTLKSRSRTELNSEDNFPAAESLRIKSKSRGDMHALQKDIDMNLKQLSRVTGGGSECTLHTGLSQGNGQEHLGQQRVRRISDEKNQNCDTSNGGVSGITSTSLLSVKTTAQKYGSTSKTPANKFERSQPMPRDRLQRNSLAESNAGTNNREKISPQFSIRDVTAMFESRSQNQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
166PhosphorylationHMGSSIASQSLGGDL
CCCCCHHHHHCCCCC		20.7318327897
168PhosphorylationGSSIASQSLGGDLPH
CCCHHHHHCCCCCCC		26.8718327897
180PhosphorylationLPHSSLRSFSPESCW
CCCCHHHCCCHHHCE		35.0622817900
348PhosphorylationSHLQKSLYEVGFFPQ
HHHHHHHHHCCCCCH		18.6918281928
629PhosphorylationDDHPARHSMVASATA
CCCHHHHHHHHHHHH		14.9221082442
635PhosphorylationHSMVASATAAAANAA
HHHHHHHHHHHHHHC		17.8421082442
792PhosphorylationDSVASRVSFVQASHA
HHHHHHHHHHHHHHH		20.7022817900
813PhosphorylationTKHDKPKSIELLETT
HCCCCCCCEEEECCC		29.8029892262
835PhosphorylationPMDLCIRSNSIDSLR
CCCEEEECCCCCCCH		18.2819429919
837PhosphorylationDLCIRSNSIDSLRTV
CEEEECCCCCCCHHC		29.0819429919
840PhosphorylationIRSNSIDSLRTVGHS
EECCCCCCCHHCCCC		20.3419429919
843PhosphorylationNSIDSLRTVGHSRSV
CCCCCCHHCCCCCCC		35.8122817900
849PhosphorylationRTVGHSRSVSHDSYF
HHCCCCCCCCCCCHH		30.8719429919
851PhosphorylationVGHSRSVSHDSYFDL
CCCCCCCCCCCHHHH		23.8719429919
854PhosphorylationSRSVSHDSYFDLLQS
CCCCCCCCHHHHHCC		23.4419429919
855PhosphorylationRSVSHDSYFDLLQSP
CCCCCCCHHHHHCCC		13.7319429919
861PhosphorylationSYFDLLQSPQRGHMT
CHHHHHCCCCCCCCC		23.9918327897
872PhosphorylationGHMTTCPSRELSELG
CCCCCCCHHHHHHCC		40.3022817900
876PhosphorylationTCPSRELSELGLNFD
CCCHHHHHHCCCCCC		26.4819429919
895PhosphorylationEMRIFSESESLVSSP
CCEEEECCCCHHCCC		31.1519429919
897PhosphorylationRIFSESESLVSSPRV
EEEECCCCHHCCCCC		43.2619429919
934PhosphorylationDFSSQTNSVNPSPKK
HHCCCCCCCCCCCCC		27.0219429919
938PhosphorylationQTNSVNPSPKKQPRL
CCCCCCCCCCCCCCC		44.1119429919
949PhosphorylationQPRLNLLSPSSARTM
CCCCCCCCCCCCCCC		26.3819429919
951PhosphorylationRLNLLSPSSARTMPP
CCCCCCCCCCCCCCC		33.0019429919
952PhosphorylationLNLLSPSSARTMPPP
CCCCCCCCCCCCCCC		25.7519429919
1029PhosphorylationKPARANQSPISSSNG
CCCCCCCCCCCCCCC		24.8222817900
1044PhosphorylationASVGSSSSSTRYSYP
CCCCCCCCCCCCCCC		37.3621082442
1048PhosphorylationSSSSSTRYSYPSVQL
CCCCCCCCCCCCCCC		16.7922817900
1049PhosphorylationSSSSTRYSYPSVQLG
CCCCCCCCCCCCCCC		27.5519429919
1050PhosphorylationSSSTRYSYPSVQLGA
CCCCCCCCCCCCCCC		7.2118281928
1070PhosphorylationQDAKERFSYQGTFTQ
HHHHHHHCCCCCCCC		23.8319429919
1071PhosphorylationDAKERFSYQGTFTQP
HHHHHHCCCCCCCCC		14.3022817900
1085PhosphorylationPGQKQESSAPRPVHS
CCCCCCCCCCCCCCC		41.3522668510
1092PhosphorylationSAPRPVHSTNNGATL
CCCCCCCCCCCCCCC		32.8222668510
1093PhosphorylationAPRPVHSTNNGATLR
CCCCCCCCCCCCCCC		20.1622668510
1118PhosphorylationQIKLHVPTPTTPARS
CEEEECCCCCCCCCC		31.9819429919
1120PhosphorylationKLHVPTPTTPARSPR
EEECCCCCCCCCCCC		48.1419429919
1121PhosphorylationLHVPTPTTPARSPRY
EECCCCCCCCCCCCE		19.0219429919
1125PhosphorylationTPTTPARSPRYSLLL
CCCCCCCCCCEEEEE		18.8119429919
1216PhosphorylationNALKRELSLDLNPLQ
HHHHHHHCCCCCCCC		18.3219429919
1281PhosphorylationQHLQRQLSMHSLLAT
HHHHHHHHHHHHHCC		13.2022817900
1284PhosphorylationQRQLSMHSLLATDES
HHHHHHHHHHCCCCC		19.2122817900
1315PhosphorylationSPIKSTISITYKSPE
CCCEEEEEEEECCCC		14.6822817900
1320PhosphorylationTISITYKSPEKEKKP
EEEEEECCCCCCCCC		28.0719429919
1339PhosphorylationETNFDENTVYEQVKL
ECCCCCCHHHHHHHH		23.5519429919
1341PhosphorylationNFDENTVYEQVKLFR
CCCCCHHHHHHHHHH		9.9019429919
1350PhosphorylationQVKLFRNSVTEVNQM
HHHHHHHHHHHHHHH		26.5921082442
1352PhosphorylationKLFRNSVTEVNQMLH
HHHHHHHHHHHHHHH		33.7521082442
1427PhosphorylationLRKPKTVYENLRGEE
HCCCCHHHHCCCCHH		12.3418281928
1453PhosphorylationVDRIELDSLDSLPDN
CCEEECCCCCCCCCC		46.8522817900
1456PhosphorylationIELDSLDSLPDNMEH
EECCCCCCCCCCCCC		47.2819429919
1466PhosphorylationDNMEHEQSSPSKSPT
CCCCCCCCCCCCCCC		41.0319429919
1467PhosphorylationNMEHEQSSPSKSPTF
CCCCCCCCCCCCCCC		32.6519429919
1469PhosphorylationEHEQSSPSKSPTFSV
CCCCCCCCCCCCCCH		47.9519429919
1471PhosphorylationEQSSPSKSPTFSVKE
CCCCCCCCCCCCHHH		33.2522817900
1485PhosphorylationELANKFESSPVEQLP
HHHHHCCCCCHHHCC		42.9719429919
1486PhosphorylationLANKFESSPVEQLPN
HHHHCCCCCHHHCCC		26.2619429919
1534PhosphorylationSAQKITRSLDENAFV
HHHHHHHHCCCCHHH		31.3619429919
1571PhosphorylationEVNSRRKSFDFTRPK
HHHHCCCCCCCCCCC		28.3919429919
1575PhosphorylationRRKSFDFTRPKTLNP
CCCCCCCCCCCCCCC		48.1619429919
1679PhosphorylationTLKSRSRTELNSEDN
HHHHCCCCCCCCCCC		46.1818327897
1699PhosphorylationSLRIKSKSRGDMHAL
HHHEEECCCCCHHHH		48.8919429919
1721PhosphorylationLKQLSRVTGGGSECT
HHHHHCCCCCCCCEE		29.0621082442
1751PhosphorylationQQRVRRISDEKNQNC
HHHHHHHHHHHCCCC		37.5921082442
1809PhosphorylationRDRLQRNSLAESNAG
HHHHHHHHHHHCCCC		31.0129892262
1824PhosphorylationTNNREKISPQFSIRD
CCCCHHCCCCCCHHH		24.5819429919
1828PhosphorylationEKISPQFSIRDVTAM
HHCCCCCCHHHHHHH		16.0921082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDGAP_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDGAP_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDGAP_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDGAP_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-168; SER-180;SER-837; SER-840; THR-843; SER-851; SER-861; SER-872; SER-876;SER-1029; THR-1118; THR-1121; SER-1125; SER-1281; SER-1284; SER-1453;SER-1456 AND THR-1679, AND MASS SPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1216, AND MASSSPECTROMETRY.

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