CDC37_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC37_RAT
• UniProt AC: Q63692
• Protein Name: Hsp90 co-chaperone Cdc37
• Gene Name: Cdc37
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 379
• Subcellular Localization: Cytoplasm .
• Protein Description: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity..
• Protein Sequence: MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDISA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVDYSVWD -------CCCCCCCC	4.70	-
2	Acetylation	------MVDYSVWDH ------CCCCCCCCC	10.73	-
4	Phosphorylation	----MVDYSVWDHIE ----CCCCCCCCCEE	8.16	27097102
5	Phosphorylation	---MVDYSVWDHIEV ---CCCCCCCCCEEC	16.56	27097102
13	Phosphorylation	VWDHIEVSDDEDETH CCCCEECCCCCCCCC	26.93	27097102
19	Phosphorylation	VSDDEDETHPNIDTA CCCCCCCCCCCCCHH	55.76	27097102
25	Phosphorylation	ETHPNIDTASLFRWR CCCCCCCHHHHHHHH	17.85	22673903
27	Phosphorylation	HPNIDTASLFRWRHQ CCCCCHHHHHHHHHH	30.08	22673903
119	Phosphorylation	NMPWNVDTLSKDGFS CCCCCHHHCCCCCCC	28.75	28432305
121	Phosphorylation	PWNVDTLSKDGFSKS CCCHHHCCCCCCCHH	30.69	28432305
155	Acetylation	KHKTFVEKYEKQIKH HHHHHHHHHHHHHHH	54.10	22902405
158	Acetylation	TFVEKYEKQIKHFGM HHHHHHHHHHHHHCC	54.99	22902405
161	Acetylation	EKYEKQIKHFGMLHR HHHHHHHHHHCCCCC	30.32	22902405
299	Phosphorylation	GLDPVEVYESLPEEL CCCHHHHHHHCHHHH	6.06	22276854
378	Phosphorylation	AGNEKDISA------ CCCCCCCCC------	37.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
13	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
13	S	Phosphorylation	Kinase	CSNK2A1	P19139	GPS
13	S	Phosphorylation	Kinase	CSNK2A2	P19784	GPS
13	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC37_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC37_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CDC37_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.