CD5R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD5R2_HUMAN
• UniProt AC: Q13319
• Protein Name: Cyclin-dependent kinase 5 activator 2
• Gene Name: CDK5R2
• Organism: Homo sapiens (Human).
• Sequence Length: 367
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Activator of CDK5/TPKII..
• Protein Sequence: MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKHWTMNLDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGTVLSLSP ------CCCEEECCC	25.24	-
2	Myristoylation	------MGTVLSLSP ------CCCEEECCC	25.24	18507738
3	O-linked_Glycosylation	-----MGTVLSLSPA -----CCCEEECCCC	19.58	30379171
3	Phosphorylation	-----MGTVLSLSPA -----CCCEEECCCC	19.58	29083192
6	Phosphorylation	--MGTVLSLSPASSA --CCCEEECCCCCCC	23.59	29083192
8	Phosphorylation	MGTVLSLSPASSAKG CCCEEECCCCCCCCC	18.29	29083192
67	Acetylation	LISALTWKRLVAASA HHHHHHHHHHHHHHH	30.53	7668563
84	Phosphorylation	KKGSKKVTPKPASTG CCCCCCCCCCCCCCC	34.18	23312004
173	Phosphorylation	APPVPGGSPRRVIVQ CCCCCCCCCCEEEEE	22.58	28102081
358	Phosphorylation	RDSCAAGTKHWTMNL HHHHCCCCCCCEECC	18.27	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
8	S	Phosphorylation	Kinase	CDK5	P49615	PSP
84	T	Phosphorylation	Kinase	CDK5	P49615	PSP
173	S	Phosphorylation	Kinase	CDK5	P49615	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD5R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD5R2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CD5R2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Myristoylation of p39 and p35 is a determinant of cytoplasmic ornuclear localization of active cyclin-dependent kinase 5 complexes.";
Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S.;
J. Neurochem. 106:1325-1336(2008).
Cited for: SUBCELLULAR LOCATION, MYRISTOYLATION, AND MUTAGENESIS OF GLY-2.
PubMed: 18507738