| UniProt ID | CD47_RAT | |
|---|---|---|
| UniProt AC | P97829 | |
| Protein Name | Leukocyte surface antigen CD47 | |
| Gene Name | Cd47 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 303 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus.. | |
| Protein Sequence | MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Pyrrolidone_carboxylic_acid | SCCCGSAQLLLSKVK HCCCCHHHHHHHCCC | 34.05 | - | |
| 19 | Pyrrolidone_carboxylic_acid | SCCCGSAQLLLSKVK HCCCCHHHHHHHCCC | 34.05 | - | |
| 34 | N-linked_Glycosylation | SVEFTSCNDTVVIPC EEEEECCCCEEEEEE | 47.99 | - | |
| 61 | N-linked_Glycosylation | MFVKWKLNKSYIFIY EEEEEEECCEEEEEE | 27.74 | - | |
| 73 | N-linked_Glycosylation | FIYDGNKNSTTREQN EEEECCCCCCCCCCC | 48.89 | - | |
| 80 | N-linked_Glycosylation | NSTTREQNFTSAKIS CCCCCCCCCCCCEEE | 37.09 | 24090084 | |
| 87 | Phosphorylation | NFTSAKISVSDLLKG CCCCCEEEHHHHHHH | 18.18 | 25403869 | |
| 89 | Phosphorylation | TSAKISVSDLLKGIA CCCEEEHHHHHHHHH | 18.75 | 25403869 | |
| 109 | N-linked_Glycosylation | THEAVVGNYTCEVTE CCHHHHCEEEEEEEE | 19.82 | 24090084 | |
| 162 | Phosphorylation | WGKFGILTLKYKSSH HHHHCCEEEEECCCC | 21.20 | 22673903 | |
| 204 | N-linked_Glycosylation | PGEKPVKNASGLGLI CCCCCCCCCCCCCEE | 39.30 | - | |
| 299 (in isoform 2) | Ubiquitination | - | 26.43 | - | |
| 309 (in isoform 2) | Ubiquitination | - | - | ||
| 311 (in isoform 2) | Phosphorylation | - | 30240740 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CD47_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CD47_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CD47_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CD47_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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