CD47_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD47_MOUSE
• UniProt AC: Q61735
• Protein Name: Leukocyte surface antigen CD47
• Gene Name: Cd47
• Organism: Mus musculus (Mouse).
• Sequence Length: 303
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection (By similarity)..
• Protein Sequence: MWPLAAALLLGSCCCGSAQLLFSNVNSIEFTSCNETVVIPCIVRNVEAQSTEEMFVKWKLNKSYIFIYDGNKNSTTTDQNFTSAKISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKNRTVSWFSPNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Pyrrolidone_carboxylic_acid	SCCCGSAQLLFSNVN HHCCCHHHHHHCCCC	40.16	-
19	Pyrrolidone_carboxylic_acid	SCCCGSAQLLFSNVN HHCCCHHHHHHCCCC	40.16	-
34	N-linked_Glycosylation	SIEFTSCNETVVIPC EEEEECCCCEEEEEE	47.98	-
50	Phosphorylation	VRNVEAQSTEEMFVK EECCCCCCCHHHHEE	44.85	29472430
51	Phosphorylation	RNVEAQSTEEMFVKW ECCCCCCCHHHHEEE	24.72	29472430
61	N-linked_Glycosylation	MFVKWKLNKSYIFIY HHEEEEECCEEEEEE	27.74	-
63	Phosphorylation	VKWKLNKSYIFIYDG EEEEECCEEEEEEEC	23.53	25521595
64	Phosphorylation	KWKLNKSYIFIYDGN EEEECCEEEEEEECC	11.06	25521595
73	N-linked_Glycosylation	FIYDGNKNSTTTDQN EEEECCCCCCCCCCC	48.89	-
80	N-linked_Glycosylation	NSTTTDQNFTSAKIS CCCCCCCCCCCCEEE	45.00	-
87	Phosphorylation	NFTSAKISVSDLING CCCCCEEEHHHHHHH	18.18	22324799
89	Phosphorylation	TSAKISVSDLINGIA CCCEEEHHHHHHHHH	21.65	22324799
97	Phosphorylation	DLINGIASLKMDKRD HHHHHHHCCCCCCCC	26.97	22324799
109	N-linked_Glycosylation	KRDAMVGNYTCEVTE CCCCCCCEEEEEEEE	19.96	-
128	Ubiquitination	GKTVIELKNRTVSWF CCEEEEECCCEEECC	31.43	27667366
129	N-linked_Glycosylation	KTVIELKNRTVSWFS CEEEEECCCEEECCC	58.44	-
162	Phosphorylation	WGKFGILTLKYKSSH HHHHCCEEEEECCCC	21.20	22006019
204	N-linked_Glycosylation	PGEKPVKNASGLGLI CCCCCCCCCCCCCEE	39.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD47_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD47_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD47_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CD47_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.