CD36_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD36_MOUSE
• UniProt AC: Q08857
• Protein Name: Platelet glycoprotein 4
• Gene Name: Cd36
• Organism: Mus musculus (Mouse).
• Sequence Length: 472
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Apical cell membrane . Membrane raft . Golgi apparatus . Upon ligand-binding, internalized through dynamin-dependent endocytosis.
• Protein Description: Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. [PubMed: 7685021 They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable)]
• Protein Sequence: MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLNLAVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPSYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIKLLGMVEMALLGIGVVMFVAFMISYCACKSKNGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	S-palmitoylation	-----MGCDRNCGLI -----CCCCCCHHHH	4.25	29705240
7	S-palmitoylation	-MGCDRNCGLIAGAV -CCCCCCHHHHHHHH	4.96	29705240
56	Ubiquitination	TAFKNWVKTGTTVYR CHHHHHHHCCCEEEE	32.62	22790023
62	Phosphorylation	VKTGTTVYRQFWIFD HHCCCEEEEEEEEEE	9.15	28059163
79	N-linked_Glycosylation	NPDDVAKNSSKIKVK CHHHHHHCCCCEEEE	41.60	-
134	N-linked_Glycosylation	SVGTEDDNFTVLNLA CEECCCCCEEEEHHH	46.97	-
205	N-linked_Glycosylation	VGVFYPYNDTVDGVY EEEEECCCCCCCEEE	33.69	-
220	N-linked_Glycosylation	KVFNGKDNISKVAII EEECCCCCEEEEEEE	43.87	-
235	N-linked_Glycosylation	ESYKGKRNLSYWPSY EECCCCCCCCCCHHH	36.50	-
247	N-linked_Glycosylation	PSYCDMINGTDAASF HHHHCCCCCCCHHHC	40.45	-
272	S-palmitoylation	RFFSSDICRSIYAVF HHCCHHHHHHHHHHH	3.15	28526873
313	Glutathionylation	NPDNHCFCTEKVISN CCCCCEECCHHHHCC	6.13	24333276
321	N-linked_Glycosylation	TEKVISNNCTSYGVL CHHHHCCCCCEECEE	24.53	-
385	Acetylation	GFTLQFAKRLQVNIL CCHHHHHHHCCCEEE	55.73	21728379
417	N-linked_Glycosylation	IVPILWLNETGTIGD EEEEEEECCCCCCCH	32.95	-
464	S-palmitoylation	VAFMISYCACKSKNG HHHHHHHHHHHCCCC	2.60	29705240
466	S-palmitoylation	FMISYCACKSKNGK- HHHHHHHHHCCCCC-	4.58	29705240

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD36_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
469	K	ubiquitylation	Ubiquitinated at Lys-469 and Lys-472.	21610069
472	K	ubiquitylation	Ubiquitinated at Lys-469 and Lys-472.	21610069

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD36_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CD36_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.