CCR6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCR6_HUMAN
• UniProt AC: P51684
• Protein Name: C-C chemokine receptor type 6
• Gene Name: CCR6
• Organism: Homo sapiens (Human).
• Sequence Length: 374
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell surface .
• Protein Description: Receptor for the C-C type chemokine CCL20. [PubMed: 9169459 Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels]
• Protein Sequence: MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	N-linked_Glycosylation	-MSGESMNFSDVFDS -CCCCCCCHHHCCCC	42.42	UniProtKB CARBOHYD
23	N-linked_Glycosylation	EDYFVSVNTSYYSVD CCEEEEEECCEEECC	18.79	UniProtKB CARBOHYD
74	Phosphorylation	VVITFAFYKKARSMT HHHHHHHHHHHHCCC	14.24	-
287	Phosphorylation	NLGKMNRSCQSEKLI HHCCCCHHHHCHHCC	16.11	30631047
347	Phosphorylation	KYKSSGFSCAGRYSE HHHCCCCCCCCEECC	13.44	30108239
352	Phosphorylation	GFSCAGRYSENISRQ CCCCCCEECCCCCHH	21.30	30108239
353	Phosphorylation	FSCAGRYSENISRQT CCCCCEECCCCCHHC	23.86	30108239
357	Phosphorylation	GRYSENISRQTSETA CEECCCCCHHCCCCC	29.89	30108239
370	Phosphorylation	TADNDNASSFTM--- CCCCCCCCCCCC---	32.04	30108239
371	Phosphorylation	ADNDNASSFTM---- CCCCCCCCCCC----	23.48	29970186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCR6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCR6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCR6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCL20_HUMAN	CCL20	physical	9169459

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.