CCM2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCM2L_HUMAN
• UniProt AC: Q9NUG4
• Protein Name: Cerebral cavernous malformations 2 protein-like
• Gene Name: CCM2L
• Organism: Homo sapiens (Human).
• Sequence Length: 571
• Protein Sequence: MEYEVKKGKKGFVSPIRRLVFPKAGRRAACRSSVSRRPLHSMPLYPPDYLIDPQILLCDYLEKEVKFLGHLTWVTSSLNPSSRDELLQLLDTARQLKELPLKTTAEQDSILSLSARCLLLTWRDNEELILRIPTHEIAAASYLQDDALHLLVLKTGLGVDPVPAGVDASPGGAGRDPGPPGGAPEKRRVGTAERRHTICSLDWRMGWGGGAAEARAGGGGGGSLERQRAGARASGSWERRQTFSGSWERRHGGGGGGGGAGKPGGSWERRQAGSGGGGSWERRHPGPNPLDPQDPSPDAYCNLVILAVANRDAAEESCALICQVFQIIYGDQSIECVDRAGYHYTSTPERPWLCSRSESCHTDGTYAYDADFSCCSSFNGSQDTFEACYSGTSTPSFHGSHCSGSDHSSLGLEQLQDYMVTLRSKLGPLEIQQFAMLLREYRLGLPIQDYCTGLLKLYGDRRKFLLLGMRPFIPDQDIGYFEGFLEGVGIREGGILTDSFGRIKRSMSSTSASAVRSYDGAAQRPEAQAFHRLLADITHDIEALAPDDDDDDEDEPRGSRGGSDAAEDNYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KGKKGFVSPIRRLVF CCCCCCCCCHHHHHC		23403867
32	Phosphorylation	GRRAACRSSVSRRPL CCHHHHCCCCCCCCC		21406692
33	Phosphorylation	RRAACRSSVSRRPLH CHHHHCCCCCCCCCC		21406692
35	Phosphorylation	AACRSSVSRRPLHSM HHHCCCCCCCCCCCC		21406692
41	Phosphorylation	VSRRPLHSMPLYPPD CCCCCCCCCCCCCCH		25072903
45	Phosphorylation	PLHSMPLYPPDYLID CCCCCCCCCCHHCCC		23663014
49	Phosphorylation	MPLYPPDYLIDPQIL CCCCCCHHCCCHHHH		23663014
60	Phosphorylation	PQILLCDYLEKEVKF HHHHHHHHHHHHCHH		23663014
97	Ubiquitination	LDTARQLKELPLKTT HHHHHHHHHCCCCCC		-
155	Phosphorylation	LHLLVLKTGLGVDPV HHHHHHHHCCCCCCC		23663014
169	Phosphorylation	VPAGVDASPGGAGRD CCCCCCCCCCCCCCC		23663014
197	Phosphorylation	GTAERRHTICSLDWR CCHHHCCEEEEECCC		28857561
200	Phosphorylation	ERRHTICSLDWRMGW HHCCEEEEECCCCCC		27251275
223	Phosphorylation	AGGGGGGSLERQRAG CCCCCCCCHHHHHHC		26846344
242	Phosphorylation	GSWERRQTFSGSWER CCCCCCCCCCCCCCC		23403867
244	Phosphorylation	WERRQTFSGSWERRH CCCCCCCCCCCCCCC		23403867
246	Phosphorylation	RRQTFSGSWERRHGG CCCCCCCCCCCCCCC		23403867
266	Phosphorylation	GAGKPGGSWERRQAG CCCCCCCCCCCCCCC		28270605
274	Phosphorylation	WERRQAGSGGGGSWE CCCCCCCCCCCCCCC		27251275
279	Phosphorylation	AGSGGGGSWERRHPG CCCCCCCCCCCCCCC		28857561
497	Phosphorylation	IREGGILTDSFGRIK CCCCCEEECCCCCCC		23403867
499	Phosphorylation	EGGILTDSFGRIKRS CCCEEECCCCCCCCC		23403867
506	Phosphorylation	SFGRIKRSMSSTSAS CCCCCCCCCCCCCHH		21955146
508	Phosphorylation	GRIKRSMSSTSASAV CCCCCCCCCCCHHHH		21955146
509	Phosphorylation	RIKRSMSSTSASAVR CCCCCCCCCCHHHHH		21955146
510	Phosphorylation	IKRSMSSTSASAVRS CCCCCCCCCHHHHHC		21955146
511	Phosphorylation	KRSMSSTSASAVRSY CCCCCCCCHHHHHCC		21955146
563	Phosphorylation	PRGSRGGSDAAEDNY CCCCCCCCCCCHHCC		23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCM2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCM2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCM2L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CCM2L_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.