| UniProt ID | CCL8_HUMAN | |
|---|---|---|
| UniProt AC | P80075 | |
| Protein Name | C-C motif chemokine 8 | |
| Gene Name | CCL8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 99 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.. | |
| Protein Sequence | MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Pyrrolidone_carboxylic_acid | FSPQGLAQPDSVSIP CCCCCCCCCCCCCCC | 47.58 | - | |
| 24 | Pyrrolidone_carboxylic_acid | FSPQGLAQPDSVSIP CCCCCCCCCCCCCCC | 47.58 | 11087354 | |
| 24 | Pyrrolidone_carboxylic_acid | FSPQGLAQPDSVSIP CCCCCCCCCCCCCCC | 47.58 | 11087354 | |
| 50 | Phosphorylation | IPIQRLESYTRITNI CCHHHHHHCEEECCC | 36.07 | 29978859 | |
| 51 | Phosphorylation | PIQRLESYTRITNIQ CHHHHHHCEEECCCC | 7.23 | 29978859 | |
| 52 | Phosphorylation | IQRLESYTRITNIQC HHHHHHCEEECCCCC | 25.52 | 29978859 | |
| 55 | Phosphorylation | LESYTRITNIQCPKE HHHCEEECCCCCCCE | 23.99 | 29978859 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCL8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCL8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCL8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CCL8_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
