| UniProt ID | CCG8_RAT | |
|---|---|---|
| UniProt AC | Q8VHW5 | |
| Protein Name | Voltage-dependent calcium channel gamma-8 subunit | |
| Gene Name | Cacng8 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 421 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. |
|
| Protein Description | Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.. | |
| Protein Sequence | MESLKRWNEERGLWCEKGVQVLLTTIGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGDDGPPHRGGSGSSEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRGSSEASPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLASAGGGGGGAGVGAYGGAAGAAGGGGTGSERDRGSSAGFLTLHNAFPKEAASGVTVTVTGPPAAPAPAPPAPAAPAPGTLSKEAAASNTNTLNRKTTPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 243 | Ubiquitination | QSRSDLLKAGGGAGG CCHHHHHHCCCCCCC | 52.89 | - | |
| 251 | Phosphorylation | AGGGAGGSGGSGPSA CCCCCCCCCCCCCCH | 38.78 | 27097102 | |
| 254 | Phosphorylation | GAGGSGGSGPSAILR CCCCCCCCCCCHHCC | 51.56 | 27097102 | |
| 257 | Phosphorylation | GSGGSGPSAILRLPS CCCCCCCCHHCCCCC | 31.31 | 28551015 | |
| 276 | Phosphorylation | YRRRSRSSSRGSSEA EECCCCCCCCCCCCC | 23.97 | 25403869 | |
| 277 | Phosphorylation | RRRSRSSSRGSSEAS ECCCCCCCCCCCCCC | 41.74 | 25403869 | |
| 280 | Phosphorylation | SRSSSRGSSEASPSR CCCCCCCCCCCCCCC | 24.72 | 25403869 | |
| 281 | Phosphorylation | RSSSRGSSEASPSRD CCCCCCCCCCCCCCC | 39.75 | 25403869 | |
| 284 | Phosphorylation | SRGSSEASPSRDASP CCCCCCCCCCCCCCC | 21.25 | 25403869 | |
| 290 | Phosphorylation | ASPSRDASPGGPGGP CCCCCCCCCCCCCCC | 28.50 | 27097102 | |
| 307 | Phosphorylation | ASTDISMYTLSRDPS CCCCEEEEEECCCCC | 9.57 | - | |
| 317 | Phosphorylation | SRDPSKGSVAAGLAS CCCCCCCCHHHHHCC | 16.60 | 26022182 | |
| 351 | Phosphorylation | AGGGGTGSERDRGSS CCCCCCCCCCCCCCC | 29.33 | 26022182 | |
| 357 | Phosphorylation | GSERDRGSSAGFLTL CCCCCCCCCCCEEEE | 20.22 | 27097102 | |
| 358 | Phosphorylation | SERDRGSSAGFLTLH CCCCCCCCCCEEEEE | 34.92 | 27097102 | |
| 411 | Phosphorylation | KEAAASNTNTLNRKT HHHHHHCCCCCCCCC | 27.38 | 25403869 | |
| 413 | Phosphorylation | AAASNTNTLNRKTTP HHHHCCCCCCCCCCC | 24.30 | 25403869 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCG8_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCG8_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCG8_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CCG8_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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