CCD93_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD93_RAT
• UniProt AC: Q5BJT7
• Protein Name: Coiled-coil domain-containing protein 93
• Gene Name: Ccdc93
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 629
• Subcellular Localization: Early endosome .
• Protein Description: Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2..
• Protein Sequence: MGLPKGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCSFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSISQFQKTYSLPEDDDFIKRKDKAIQTVVDLSDAYKPRRKYRRQQGAEELLDEESRVHSTLLEYGRRHGFSRQSKTEKAEDKKTALAAGLSAAEKTDAHEEDELQAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYEGKQSELSAEESPEKLGTSQLHQRKVISLNKQILQKTKHLEELQANHTSLQAKYSDKKKTLTELKNHGEKLDQEQAALEKLEAKADPSILQNLRALVAMNESLKSQEQEFKAHCREEMARLQQEIEILKAERAPGEKTISSGEPQGALTSTMTHNEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNELLLSKIKAKAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
151	Phosphorylation	SQFQKTYSLPEDDDF HHHHHHCCCCCCCHH	42.55	28432305
196	Phosphorylation	EELLDEESRVHSTLL HHHCCHHHHHHHHHH	37.24	22276854
273	Phosphorylation	EESRLTASSVGQIVG HHHHCCHHHHHHHHH	21.96	28826663
274	Phosphorylation	ESRLTASSVGQIVGL HHHCCHHHHHHHHHH	28.01	28826663
283	Phosphorylation	GQIVGLCSAEIKQIV HHHHHHCHHHHHHHH	33.70	28826663
293	Phosphorylation	IKQIVSEYEGKQSEL HHHHHHHHCCCCCCC	23.60	28826663
298	Phosphorylation	SEYEGKQSELSAEES HHHCCCCCCCCCCCC	43.95	27097102
301	Phosphorylation	EGKQSELSAEESPEK CCCCCCCCCCCCHHH	29.59	28551015
305	Phosphorylation	SELSAEESPEKLGTS CCCCCCCCHHHHCCC	29.84	27097102
311	Phosphorylation	ESPEKLGTSQLHQRK CCHHHHCCCHHHHHH	24.60	27097102
312	Phosphorylation	SPEKLGTSQLHQRKV CHHHHCCCHHHHHHH	29.01	27097102
599	Ubiquitination	QYLELLEKQRLYFKT HHHHHHHHHCHHHHC	40.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD93_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD93_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD93_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD93_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.