CCD86_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD86_MOUSE
• UniProt AC: Q9JJ89
• Protein Name: Coiled-coil domain-containing protein 86
• Gene Name: Ccdc86
• Organism: Mus musculus (Mouse).
• Sequence Length: 426
• Subcellular Localization: Nucleus .
• Protein Sequence: MDTPLRRSRRLEGLKPLSPENLPVPEVSRAKRALVDFKSNSEETGELKSTRVPPLSLPSPGPQPETSPGSPCPPLSLPSPGPQPETSPGSPCPPLSLPSPGPQPETSPGSPCPPLSLPSPGPQPETSPGSPCPPLSLPSPGPQPEASPGSPGPRQDADDGSPQRQPEPHPGSLQPHQDLGLESPAGQTESSPESPQREQPSKLPPPQGELDSEAAHAKEEVIPGSPEPCPGQQAPGPEPSQPAQELTVQAPSSPERQLEPGKLPPAGETVTESLNLKKRVIASPQAPASKKLKEKEELPVIPKGKPKSGRVWKDRSKKRFSQMVQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKQRRRQEKKERRAENLRRRLENERKAEIVQVIRNPAKLKKAKKKQLRSIEKRDTLALLQKQPPQRPVAKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTPLRRSRR -----CCCCCHHHHC	23.95	29895711
8	Phosphorylation	MDTPLRRSRRLEGLK CCCCCHHHHCCCCCC	18.47	27600695
18	Phosphorylation	LEGLKPLSPENLPVP CCCCCCCCHHCCCCC	38.40	26824392
28	Phosphorylation	NLPVPEVSRAKRALV CCCCCHHHHHHHHHC	25.51	25619855
39	Phosphorylation	RALVDFKSNSEETGE HHHCCCCCCCCCCCC	45.65	30635358
41	Phosphorylation	LVDFKSNSEETGELK HCCCCCCCCCCCCCC	43.85	27841257
44	Phosphorylation	FKSNSEETGELKSTR CCCCCCCCCCCCCCC	31.72	30635358
59	Phosphorylation	VPPLSLPSPGPQPET CCCCCCCCCCCCCCC	48.02	-
66	Phosphorylation	SPGPQPETSPGSPCP CCCCCCCCCCCCCCC	47.07	-
67	Phosphorylation	PGPQPETSPGSPCPP CCCCCCCCCCCCCCC	26.12	-
70	Phosphorylation	QPETSPGSPCPPLSL CCCCCCCCCCCCCCC	27.06	-
161	Phosphorylation	RQDADDGSPQRQPEP CCCCCCCCCCCCCCC	25.50	25159016
172	Phosphorylation	QPEPHPGSLQPHQDL CCCCCCCCCCCCCCC	28.43	20531401
183	Phosphorylation	HQDLGLESPAGQTES CCCCCCCCCCCCCCC	25.70	25159016
188	Phosphorylation	LESPAGQTESSPESP CCCCCCCCCCCCCCC	36.60	25159016
190	Phosphorylation	SPAGQTESSPESPQR CCCCCCCCCCCCCCC	55.36	25159016
191	Phosphorylation	PAGQTESSPESPQRE CCCCCCCCCCCCCCC	26.84	25159016
194	Phosphorylation	QTESSPESPQREQPS CCCCCCCCCCCCCCC	29.71	26824392
225	Phosphorylation	KEEVIPGSPEPCPGQ HCCCCCCCCCCCCCC	22.27	25521595
240	Phosphorylation	QAPGPEPSQPAQELT CCCCCCCCCCCCCEE	47.32	21149613
247	Phosphorylation	SQPAQELTVQAPSSP CCCCCCEEECCCCCH	15.15	21149613
252	Phosphorylation	ELTVQAPSSPERQLE CEEECCCCCHHHHCC	62.63	25521595
253	Phosphorylation	LTVQAPSSPERQLEP EEECCCCCHHHHCCC	29.71	25521595
283	Phosphorylation	LKKRVIASPQAPASK CCHHHHCCCCCCHHH	13.35	27087446
289	Phosphorylation	ASPQAPASKKLKEKE CCCCCCHHHHCCCHH	29.30	25159016
321	Phosphorylation	DRSKKRFSQMVQDKP HHHHHHHHHHHHCCC	22.77	-
404	Phosphorylation	AKKKQLRSIEKRDTL HHHHHHHHHHHHHHH	43.63	28059163
408	Citrullination	QLRSIEKRDTLALLQ HHHHHHHHHHHHHHH	29.38	-
408	Citrullination	QLRSIEKRDTLALLQ HHHHHHHHHHHHHHH	29.38	24463520

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD86_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD86_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD86_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD86_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.
PubMed: 19367708