CCD73_HUMAN - dbPTM
CCD73_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCD73_HUMAN
UniProt AC Q6ZRK6
Protein Name Coiled-coil domain-containing protein 73
Gene Name CCDC73
Organism Homo sapiens (Human).
Sequence Length 1079
Subcellular Localization
Protein Description
Protein Sequence MESNFNTESSSTFTLQSSSETLFSIQLLDFKTSLLEALEELRMRREAEIHYEEQIGKIIVETQELKWQKETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKALQVSKYSLQKKVSEMEQKVQLHLLAKEDYHKQLSEIEKYYATITGQFGLVKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGEENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQANTEMEAELKVLKENNQTLERDNELQREKVKENEEKFLNLQNEHEKALGTWKRHAEELNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQNVPEVNNENSEMSTEKSENTIIQKYNTEQEIREENMENFCSDTEYREKEEKKEGSFIEEIIIDDLQLFEKSFKNEIDTVVSQDENQSEISLSKTLSLDKEVISQGQTSNVTDNRKSVTTEIKDKICLEKDNGCTEFKSPNNHFVVLDTAIETEKIHLERTRGLDVHHTDVNLEVENNKTSFNSILNETAHNTYHNNNKDVSENEPFKQFRLLPGTREHALEKEITNSDQTKADLDSSLDIKKNPVPCQKYSLRNSSNVMLDDKQCKIKQIQLLTKKSECSILLSKQTSDFLQVCNDTLEKSELTVPCDIVIDHHVSYAAFSANSKLLLKNSDKNVHSMSMLVKPNSSPGGKTMCKNMSDMQNSQFNNCLGYLENTNVNISHLHLNNENSHASQAKDVKTAVHMKTCTETEFSNKKNQIDENQVTEATKNDLFLFVSINERQHTLLNNTEKTESLNDIVSGKMFSEGQLEESHSFHIEPSGDLVNRSGRSTFDLSTSDKKTEKTPVYMNFSDPGPWSKVNHIESQTASSSTPCISLLLKERPLDPSENKKIISMALCKNIGVDDVGKDIGPDTTSINRVADTLNNWSIHPDPKGEPSEEKNAMAKTFYDSSFPTEHVKTKPLISTPLQSHLQAIKTTKNTSGDDDWQSLITNQLNKSENLLSLENDNQPKKRKAEETLEKNNRLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationRREAEIHYEEQIGKI
HHHHCCCHHHHHHCC		27.1625159151
97MethylationFKKQLQMKMCALEEE
HHHHHHHHHHHHHHH		20.19-
141PhosphorylationYSLQKKVSEMEQKVQ
HHHHHHHHHHHHHHH		39.8522798277
195PhosphorylationNVREAIQSNKRLSAL
HHHHHHHHCHHHHHH		37.90-
222PhosphorylationKELKKAASDLIKSKV
HHHHHHHHHHHHHHC		37.5029457462
227PhosphorylationAASDLIKSKVTCQYK
HHHHHHHHHCCCCEE		25.9322798277
366PhosphorylationNKIKNELSSLKETHI
HHHHHHHHHHHHHHH		27.6924719451
420PhosphorylationENTIIQKYNTEQEIR
HHHHHHHCCCHHHHH		15.7930576142
436PhosphorylationENMENFCSDTEYREK
HHHHHHCCCHHHHHH		43.35-
438PhosphorylationMENFCSDTEYREKEE
HHHHCCCHHHHHHHH		20.72-
440PhosphorylationNFCSDTEYREKEEKK
HHCCCHHHHHHHHHH		26.60-
473PhosphorylationSFKNEIDTVVSQDEN
HHHHHHCEECCCCCC		28.59-
476PhosphorylationNEIDTVVSQDENQSE
HHHCEECCCCCCCCC		27.81-
485PhosphorylationDENQSEISLSKTLSL
CCCCCCEEEEEEEEC		23.6524719451
646PhosphorylationPVPCQKYSLRNSSNV
CCCCCHHCCCCCCCC		28.0824719451
696PhosphorylationCNDTLEKSELTVPCD
HCHHHCCCCCCCCCC		28.5922468782
699PhosphorylationTLEKSELTVPCDIVI
HHCCCCCCCCCCEEE		20.5322468782
711PhosphorylationIVIDHHVSYAAFSAN
EEEECCCHHHHHCCC		12.5122468782
712PhosphorylationVIDHHVSYAAFSANS
EEECCCHHHHHCCCC		10.8122468782
726PhosphorylationSKLLLKNSDKNVHSM
CCEEECCCCCCCEEE		48.6620873877
734PhosphorylationDKNVHSMSMLVKPNS
CCCCEEEEEEECCCC		16.3924114839
738AcetylationHSMSMLVKPNSSPGG
EEEEEEECCCCCCCC		34.2212439293
741PhosphorylationSMLVKPNSSPGGKTM
EEEECCCCCCCCCCC		46.5728509920
742PhosphorylationMLVKPNSSPGGKTMC
EEECCCCCCCCCCCC		33.9224114839
747PhosphorylationNSSPGGKTMCKNMSD
CCCCCCCCCCCCHHH		30.9529116813
800PhosphorylationKTAVHMKTCTETEFS
HHHHHHCCCCHHHHC		19.6529052541
802PhosphorylationAVHMKTCTETEFSNK
HHHHCCCCHHHHCCC		51.6924114839
804PhosphorylationHMKTCTETEFSNKKN
HHCCCCHHHHCCCCC		24.9529052541
807PhosphorylationTCTETEFSNKKNQID
CCCHHHHCCCCCCCC		41.3224114839
885PhosphorylationVNRSGRSTFDLSTSD
CCCCCCCCEECCCCC		21.5826699800
889PhosphorylationGRSTFDLSTSDKKTE
CCCCEECCCCCCCCC		27.9226699800
890PhosphorylationRSTFDLSTSDKKTEK
CCCEECCCCCCCCCC		48.5226699800
891PhosphorylationSTFDLSTSDKKTEKT
CCEECCCCCCCCCCC		44.0226699800
895PhosphorylationLSTSDKKTEKTPVYM
CCCCCCCCCCCCCCC		48.7526699800
898PhosphorylationSDKKTEKTPVYMNFS
CCCCCCCCCCCCCCC		16.2622964224
905PhosphorylationTPVYMNFSDPGPWSK
CCCCCCCCCCCCHHH		37.5822964224
947PhosphorylationSENKKIISMALCKNI
HHCHHHHHHHHHHHC		11.0729083192
967PhosphorylationGKDIGPDTTSINRVA
CCCCCCCCHHHHHHH		26.1017693683
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCD73_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCD73_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCD73_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CCD73_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCD73_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-967, AND MASSSPECTROMETRY.

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