CCD39_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD39_HUMAN
• UniProt AC: Q9UFE4
• Protein Name: Coiled-coil domain-containing protein 39 {ECO:0000305}
• Gene Name: CCDC39 {ECO:0000312|HGNC:HGNC:25244}
• Organism: Homo sapiens (Human).
• Sequence Length: 941
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . CCDC40 is required for localization to axonemes.
• Protein Description: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. [PubMed: 21131972 Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity Not required for outer dynein arm complexes assembly]
• Protein Sequence: MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSEFLAEL ------CCHHHHHHH	38.28	25693802
3 (in isoform 2)	Phosphorylation	-	30.94	24043423
3	Phosphorylation	-----MSSEFLAELH -----CCHHHHHHHC	30.94	25693802
8 (in isoform 2)	Phosphorylation	-	43.23	24043423
13 (in isoform 2)	Phosphorylation	-	52.93	24043423
48	Phosphorylation	LQDELREYEERINSM HHHHHHHHHHHHHHH	19.36	26074081
54	Phosphorylation	EYEERINSMTSHFKN HHHHHHHHHHHHHHH	22.52	26074081
98	Ubiquitination	QRELGRVKDEIQRLE HHHHHHHHHHHHHHH	48.56	-
110	Phosphorylation	RLENEMASILEKKSD HHHHHHHHHHHHHCH	26.79	24719451
284	Phosphorylation	TEFEKRISVADRKLL CHHHHHHHHHHHHHH	18.45	-
313	Phosphorylation	QLKGELDSLKATVNR EEHHHHHHHHHHHCC	44.38	-
322	Phosphorylation	KATVNRTSSDLEALR HHHHCCCHHHHHHHH	20.72	29457462
323	Phosphorylation	ATVNRTSSDLEALRK HHHCCCHHHHHHHHH	45.67	29457462
364	Phosphorylation	QTKLKEITEKTMSVE HHHHHHHHHHHCCHH	32.30	30622161
367	Phosphorylation	LKEITEKTMSVEEKA HHHHHHHHCCHHHHC	14.40	30622161
369	Phosphorylation	EITEKTMSVEEKATN HHHHHHCCHHHHCCC	31.44	30622161
375	Phosphorylation	MSVEEKATNLEDMLK CCHHHHCCCHHHHHH	51.94	24667141
421	Phosphorylation	MKEKAVLSEIEGTRS HHHHHHHHHHHCHHH	29.90	-
584	Phosphorylation	SKAEEVLSLEKRKQQ HHHHHHHCHHHHHHH	39.39	-
593	Phosphorylation	EKRKQQLYTAMEERT HHHHHHHHHHHHHHH	6.52	-
659	Phosphorylation	PEGEEEKTQAYYVIK CCCCCHHHHHHHHHH	23.01	27067055
662	Phosphorylation	EEEKTQAYYVIKAAQ CCHHHHHHHHHHHHH	6.61	27067055
663	Phosphorylation	EEKTQAYYVIKAAQE CHHHHHHHHHHHHHH	9.94	27067055
717	Phosphorylation	KQSFKKVTPSSDEYE HHHHEECCCCCCCCE	26.74	30622161
719	Phosphorylation	SFKKVTPSSDEYELK HHEECCCCCCCCEEE	40.84	30622161
720	Phosphorylation	FKKVTPSSDEYELKI HEECCCCCCCCEEEH	35.35	30622161
743	Methylation	VDEKYRYKQRQIREL HHHHHHHHHHHHHHH	29.97	23644510
776	Phosphorylation	NNVKEKLSEKQAYSF HHHHHHHCHHHHHHH	54.54	25072903
781	Phosphorylation	KLSEKQAYSFQLSKE HHCHHHHHHHHCCCC	13.92	25072903
782	Phosphorylation	LSEKQAYSFQLSKET HCHHHHHHHHCCCCC	14.99	25072903
786	Phosphorylation	QAYSFQLSKETEEQK HHHHHHCCCCCHHHC	20.05	25072903
817	Ubiquitination	IRLLKDTKDETMEEQ HHHHHCCCCCCHHHH	64.80	29967540
869	Phosphorylation	QSGLELPTASTKGSR HCCCCCCCCCCCCCC	45.95	25693802
871	Phosphorylation	GLELPTASTKGSRQS CCCCCCCCCCCCCCC	32.88	25693802
872	Phosphorylation	LELPTASTKGSRQSS CCCCCCCCCCCCCCC	36.64	25693802
892	Phosphorylation	TSLSARSSRSTSTST CCCCCCCCCCCCCCC	25.38	-
900	Phosphorylation	RSTSTSTSQSSIKVL CCCCCCCCCCCEEEE	28.03	-
914	Phosphorylation	LELKFPASSSLVGSP EEEECCCCCCCCCCC	22.24	30631047
920	Phosphorylation	ASSSLVGSPSRPSSA CCCCCCCCCCCCCCC	16.54	30631047
925	Phosphorylation	VGSPSRPSSASSSSS CCCCCCCCCCCCCCC	37.11	27251275
926	Phosphorylation	GSPSRPSSASSSSSN CCCCCCCCCCCCCCC	34.55	27251275
928	Phosphorylation	PSRPSSASSSSSNVK CCCCCCCCCCCCCCC	32.47	25332170
929	Phosphorylation	SRPSSASSSSSNVKS CCCCCCCCCCCCCCC	33.68	27251275
930	Phosphorylation	RPSSASSSSSNVKSK CCCCCCCCCCCCCCC	34.98	27251275
931	Phosphorylation	PSSASSSSSNVKSKK CCCCCCCCCCCCCCC	28.07	27251275
932	Phosphorylation	SSASSSSSNVKSKKS CCCCCCCCCCCCCCC	47.81	25332170
936	Phosphorylation	SSSSNVKSKKSSK-- CCCCCCCCCCCCC--	40.82	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD39_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD39_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD39_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD39_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.