CCD14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD14_MOUSE
• UniProt AC: Q8K2J4
• Protein Name: Coiled-coil domain-containing protein 14
• Gene Name: Ccdc14
• Organism: Mus musculus (Mouse).
• Sequence Length: 934
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Colocalizes with PCM1 at centriolar satellites throughout the cell cycle.
• Protein Description: Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization..
• Protein Sequence: MSPGGPRPSSRKRKLRGRDKGGPDISAVNSFFLKYSFPYAWALLRLREMVRSGSRPGQVISSGRQPGAKLPNGKKGTHVRKIAHFNVDSACPVQSDSESQTDTLQGLDGCASLLRDILKNEDSGSEMVYSENRCNSKPLEGRKNRSKKKGPEKHVPSVVRKEILSSENRKWISNEASTGSDTAQRWSLQDHYRMYSPIIYQALCEHVQTQMSLMNSLALKNGPNGIHAVCHTMSNSGSQATPHSGFGCSPSASVWPPQQPSCPLMVHSEVQTDADNQFESQSQATSVKYGDVPRDPFSVHPGVACGLPHADSPAVAKSRQLDLTSCILPQQRAPKEAELLKCFQTHTSLFPAHGKDALSDSQAYQSPSQLQPAFLATNEEKCAKEQFEEATNEGKHLSTHVQDAKIAKNVQQAENVSQTAEKIRLAKCLLGELKALMEEDSEVQRLVTEVEACVSGLSAVSGHPNVEVEIALALQPLRSENAQLRRQLRILNQRLREQEKTEKGPGNLELFSLQSLNMSLQNQLQESLKSQELLQSKNEELLKVIENQKEENKKFTTLFKDKEQTLLHNKQQFDIEMTRVKMELEEALANEKNLRFKLETAEKESQILGITLRQRDAEVARLRELTRTLQSSMAKLLSDLSMDTARCRMGNSLTKSLLNVYDQQLQQDPAPAQTSIMSYLNKLETNHSFIHSKLLNNEAAIEPDRLCESVLPPQRPPHSDAGTADGGSASGTVSAASVEDSDMDCETLTVIEDGCNVDSTVYIPFARNTSKKHSPLCKRLSPQPKLSVAAAQLVSGSAQTSKGESKPRAPAVCSSRNEAEDAPGDLSSTYDTEDVQLLRKIKEAIGKIPAAAEHAKEQATHHGPSAHPSPGVPVKGSIVPDSSFLNSDLMSDWSISSFSTFTSHDEQDFRNGLAALDANIARLQKSLKTGLLEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	DILKNEDSGSEMVYS HHHHCCCCCCCCEEC	37.73	28066266
125	Phosphorylation	LKNEDSGSEMVYSEN HHCCCCCCCCEECCC	26.86	28066266
147	Acetylation	EGRKNRSKKKGPEKH CCCCCCCCCCCCCCC	56.09	7969783
149	Acetylation	RKNRSKKKGPEKHVP CCCCCCCCCCCCCCC	81.22	7969791
177	Phosphorylation	KWISNEASTGSDTAQ CCCCCCCCCCCCHHH	27.42	28066266
178	Phosphorylation	WISNEASTGSDTAQR CCCCCCCCCCCHHHH	47.99	28066266
180	Phosphorylation	SNEASTGSDTAQRWS CCCCCCCCCHHHHHC	31.70	28066266
182	Phosphorylation	EASTGSDTAQRWSLQ CCCCCCCHHHHHCHH	26.79	28066266
656	Phosphorylation	MGNSLTKSLLNVYDQ CCHHHHHHHHHHHHH	32.62	-
685	Phosphorylation	SYLNKLETNHSFIHS HHHHHHHHCHHHHHH	48.98	28066266
688	Phosphorylation	NKLETNHSFIHSKLL HHHHHCHHHHHHHHH	28.15	28066266
692	Phosphorylation	TNHSFIHSKLLNNEA HCHHHHHHHHHCCCC	21.86	28066266
737	Phosphorylation	SGTVSAASVEDSDMD CCEEEEEECCCCCCC	26.25	-
781	Phosphorylation	SPLCKRLSPQPKLSV CHHHHCCCCCCCHHH	26.06	29895711
787	Phosphorylation	LSPQPKLSVAAAQLV CCCCCCHHHHHHHHH	18.81	29895711
795	Phosphorylation	VAAAQLVSGSAQTSK HHHHHHHHCCCCCCC	35.31	29895711
800	Phosphorylation	LVSGSAQTSKGESKP HHHCCCCCCCCCCCC	31.93	29895711
801	Phosphorylation	VSGSAQTSKGESKPR HHCCCCCCCCCCCCC	26.95	29895711
860	Phosphorylation	EHAKEQATHHGPSAH HHHHHHHHHCCCCCC	17.69	28066266
865	Phosphorylation	QATHHGPSAHPSPGV HHHHCCCCCCCCCCC	43.75	28066266
869	Phosphorylation	HGPSAHPSPGVPVKG CCCCCCCCCCCCCCC	25.15	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD14_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD14_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.