CCBE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCBE1_HUMAN
• UniProt AC: Q6UXH8
• Protein Name: Collagen and calcium-binding EGF domain-containing protein 1
• Gene Name: CCBE1
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Secreted .
• Protein Description: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis..
• Protein Sequence: MVPPPPSRGGAARGQLGRSLGPLLLLLALGHTWTYREEPEDGDREICSESKIATTKYPCLKSSGELTTCYRKKCCKGYKFVLGQCIPEDYDVCAEAPCEQQCTDNFGRVLCTCYPGYRYDRERHRKREKPYCLDIDECASSNGTLCAHICINTLGSYRCECREGYIREDDGKTCTRGDKYPNDTGHEKSENMVKAGTCCATCKEFYQMKQTVLQLKQKIALLPNNAADLGKYITGDKVLASNTYLPGPPGLPGGQGPPGSPGPKGSPGFPGMPGPPGQPGPRGSMGPMGPSPDLSHIKQGRRGPVGPPGAPGRDGSKGERGAPGPRGSPGPPGSFDFLLLMLADIRNDITELQEKVFGHRTHSSAEEFPLPQEFPSYPEAMDLGSGDDHPRRTETRDLRAPRDFYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	41.86	24043423
7 (in isoform 2)	Phosphorylation	-	49.70	24043423
19	Phosphorylation	ARGQLGRSLGPLLLL CCHHHHHHHHHHHHH	35.56	22210691
32	Phosphorylation	LLLALGHTWTYREEP HHHHHCCCEECCCCC	20.08	22210691
34	Phosphorylation	LALGHTWTYREEPED HHHCCCEECCCCCCC	17.54	22210691
54	Phosphorylation	CSESKIATTKYPCLK CCCCCCEECCCCCCC	27.56	20873877
55	Phosphorylation	SESKIATTKYPCLKS CCCCCEECCCCCCCC	21.40	20873877
57	Phosphorylation	SKIATTKYPCLKSSG CCCEECCCCCCCCCC	9.33	20873877
70	Phosphorylation	SGELTTCYRKKCCKG CCCCCEEECCCCCCC	24.31	-
142	N-linked_Glycosylation	IDECASSNGTLCAHI HHHHHHCCCCEEEEE	45.00	UniProtKB CARBOHYD
182	N-linked_Glycosylation	TRGDKYPNDTGHEKS CCCCCCCCCCCCCCC	57.28	UniProtKB CARBOHYD
206	Phosphorylation	CATCKEFYQMKQTVL CHHHHHHHHHHHHHH	14.59	25954137
216	Acetylation	KQTVLQLKQKIALLP HHHHHHHHHHHHHCC	36.26	25953088
234	Phosphorylation	ADLGKYITGDKVLAS HHHHHHCCCCCEECC	35.92	24719451
243	Phosphorylation	DKVLASNTYLPGPPG CCEECCCCCCCCCCC	24.76	24719451
282	Methylation	PPGQPGPRGSMGPMG CCCCCCCCCCCCCCC	56.59	-
316	Phosphorylation	GAPGRDGSKGERGAP CCCCCCCCCCCCCCC	41.60	-
328	Phosphorylation	GAPGPRGSPGPPGSF CCCCCCCCCCCCCCH	28.15	30243723
334	Phosphorylation	GSPGPPGSFDFLLLM CCCCCCCCHHHHHHH	27.67	30243723
361	Phosphorylation	EKVFGHRTHSSAEEF HHHHCCCCCCCHHHC	22.04	28857561
363	Phosphorylation	VFGHRTHSSAEEFPL HHCCCCCCCHHHCCC	30.54	28857561
364	Phosphorylation	FGHRTHSSAEEFPLP HCCCCCCCHHHCCCC	31.90	22210691
393	Phosphorylation	GDDHPRRTETRDLRA CCCCCCCCCCCCCCC	42.88	22210691
395	Phosphorylation	DHPRRTETRDLRAPR CCCCCCCCCCCCCCC	28.95	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCBE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCBE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCBE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIAH2_HUMAN	SIAH2	physical	21988832
TOX4_HUMAN	TOX4	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.