CC105_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC105_HUMAN
• UniProt AC: Q8IYK2
• Protein Name: Coiled-coil domain-containing protein 105
• Gene Name: CCDC105
• Organism: Homo sapiens (Human).
• Sequence Length: 499
• Protein Sequence: MRVLVPPAERSQDTRVGAPAWREAAQAMARTAHILTDRCGQEAVTMWQPKDSVLDPNVAHHLGRAAYIQPWRFRVEMIKGGGTLEKPPPGEGVTLWKGKMKPPAWYARLPLPLHRKARALQTTEVVHAHARGARLTAARLGRAQHQINGRVRQLLRQREVTDHRLSEVRKGLLINQQSVKLRGYRPKSEKVPDKADSMLTWEKEELKSMKRKMERDMEKSEVLLKTLASCRDTLNFCFKERLQAVDLMNQPLDKVLEQARRHSWVNLSRAPTPRTQGQKTPPPDPVGTYNPACALALNEAKRLLVESKDTLVEMAKNEVDVREQQLQISDRVCASLAQKASETLELKERLNMTLGLMRGTILRCTKYNQELYTTHGLIKGPLSKVHLETAEKLDRPLVRMYQRHVGTQLPEAARLAQGTDKLQCHITYLEKNLDELLATHKNLSWGLNCKNIGHEVDGNVVRLRLRQRQPHVCYEQAQRLVKDWDPRTPPPRSKSSADP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	Phosphorylation	EVTDHRLSEVRKGLL CCCHHHHHHHHHCCC	33.72	23532336
197	Phosphorylation	KVPDKADSMLTWEKE CCCCCHHHCCHHCHH	22.13	30622161
200	Phosphorylation	DKADSMLTWEKEELK CCHHHCCHHCHHHHH	23.96	30622161
220	Phosphorylation	MERDMEKSEVLLKTL HHHHHHHHHHHHHHH	21.45	23911959
239	Acetylation	DTLNFCFKERLQAVD HHHHHHHHHHHHHHH	43.01	25038526
268	Phosphorylation	RHSWVNLSRAPTPRT HHCCCCCCCCCCCCC	22.61	30622161
272	Phosphorylation	VNLSRAPTPRTQGQK CCCCCCCCCCCCCCC	25.15	25693802
275	Phosphorylation	SRAPTPRTQGQKTPP CCCCCCCCCCCCCCC	37.95	30622161
280	Phosphorylation	PRTQGQKTPPPDPVG CCCCCCCCCCCCCCC	32.89	30622161
288	Phosphorylation	PPPDPVGTYNPACAL CCCCCCCCCCHHHHH	21.99	25693802
289	Phosphorylation	PPDPVGTYNPACALA CCCCCCCCCHHHHHH	17.14	25693802
343	Phosphorylation	LAQKASETLELKERL HHHHHHHHHHHHHHH	24.04	29457462
353	Phosphorylation	LKERLNMTLGLMRGT HHHHHHHHHHHHHHH	19.32	26074081
360	Phosphorylation	TLGLMRGTILRCTKY HHHHHHHHHHHHHCC	13.38	26074081
365	Phosphorylation	RGTILRCTKYNQELY HHHHHHHHCCCHHHH	30.08	26074081
366	Acetylation	GTILRCTKYNQELYT HHHHHHHCCCHHHHH	45.92	25038526
367	Phosphorylation	TILRCTKYNQELYTT HHHHHHCCCHHHHHC	12.15	26074081
372	Nitration	TKYNQELYTTHGLIK HCCCHHHHHCCCEEC	14.61	-
372	Phosphorylation	TKYNQELYTTHGLIK HCCCHHHHHCCCEEC	14.61	-
383	Phosphorylation	GLIKGPLSKVHLETA CEECCCCHHHHHHHH	35.45	-
389	Phosphorylation	LSKVHLETAEKLDRP CHHHHHHHHHHCCCH	46.61	30622161
488	Phosphorylation	VKDWDPRTPPPRSKS HHCCCCCCCCCCCCC	45.60	30622161
493	Phosphorylation	PRTPPPRSKSSADP- CCCCCCCCCCCCCC-	42.54	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC105_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC105_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC105_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CC105_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.