CBWD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBWD5_HUMAN
• UniProt AC: Q5RIA9
• Protein Name: COBW domain-containing protein 5
• Gene Name: CBWD5
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Protein Sequence: MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVTSMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLPAVGSVDEEEDP -CCCCCCCCCCCCCC	21.57	30624053
34 (in isoform 2)	Ubiquitination	-	56.66	21890473
41 (in isoform 1)	Ubiquitination	-	45.83	21890473
41	Ubiquitination	EKSGLGAKIPVTIIT HHCCCCCCCCEEEEE	45.83	21906983
55 (in isoform 1)	Ubiquitination	-	37.49	21890473
55	Ubiquitination	TGYLGAGKTTLLNYI ECCCCCCHHHHHHHH	37.49	21906983
57 (in isoform 2)	Ubiquitination	-	32.50	21890473
69	Ubiquitination	ILTEQHSKRVAVILN HHCCCCCCEEEEEEC	49.09	21906983
69 (in isoform 1)	Ubiquitination	-	49.09	21890473
78	Phosphorylation	VAVILNESGEGSALE EEEEECCCCCCCHHH	40.86	24114839
79 (in isoform 2)	Ubiquitination	-	36.79	21890473
82	Phosphorylation	LNESGEGSALEKSLA ECCCCCCCHHHHHEE	25.94	24114839
91	Phosphorylation	LEKSLAVSQGGELYE HHHHEEECCCCHHHH	19.94	-
97	Phosphorylation	VSQGGELYEEWLELR ECCCCHHHHHHHHHH	13.90	-
126	Ubiquitination	AIENLMQKKGKFDDI HHHHHHHHCCCCCHH	49.91	21906983
126 (in isoform 1)	Ubiquitination	-	49.91	21890473
176	Ubiquitination	VDSKYGLKHLTEEKP EECCCCHHHCCCCCC	32.00	21906983
176 (in isoform 1)	Ubiquitination	-	32.00	21890473
182	Ubiquitination	LKHLTEEKPDGLINE HHHCCCCCCCCHHCH	42.02	21906983
182 (in isoform 1)	Ubiquitination	-	42.02	21890473
214	Ubiquitination	LVPEEDVKKLRTTIR CCCHHHHHHHHHHHH	59.41	21906983
214 (in isoform 1)	Ubiquitination	-	59.41	21890473
222	Phosphorylation	KLRTTIRSINGLGQI HHHHHHHHHCCHHHH	19.29	27251275
232	Phosphorylation	GLGQILETQRSRVDL CHHHHHHHHHHCCCH	26.32	27251275
235	Phosphorylation	QILETQRSRVDLSNV HHHHHHHHCCCHHHH	27.17	27251275
255	Phosphorylation	FDSLSGISLQKKLQH HHCCCCCCHHHHHHC	28.42	24719451
258	Ubiquitination	LSGISLQKKLQHVPG CCCCCHHHHHHCCCC	61.82	-
258 (in isoform 1)	Ubiquitination	-	61.82	21890473
306	Ubiquitination	WEKNVRNKDNHCMEV HHHHCCCCCCCHHHE	49.71	-
325	Ubiquitination	GLVSIKDKSQQVIVQ EEEECCCCCCEEEEE	45.20	21906983
325 (in isoform 1)	Ubiquitination	-	45.20	21890473
348	Ubiquitination	EETPVSWKDDTERTN CCCCCCCCCCCCCCC	37.91	21906983
348 (in isoform 1)	Ubiquitination	-	37.91	21890473
370	Ubiquitination	NLDKDILKQLFIATV CCCHHHHHHHHHCCC	45.34	-
370 (in isoform 1)	Ubiquitination	-	45.34	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBWD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBWD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBWD5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CBWD5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.