CBWD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBWD3_HUMAN
• UniProt AC: Q5JTY5
• Protein Name: COBW domain-containing protein 3
• Gene Name: CBWD3
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Protein Sequence: MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLPAVGSVDEEEDP -CCCCCCCCCCCCCC	21.57	30624053
41	Ubiquitination	EKSGLGAKIPVTIIT HHCCCCCCCCEEEEE	45.83	21890473
41	Ubiquitination	EKSGLGAKIPVTIIT HHCCCCCCCCEEEEE	45.83	-
41	Ubiquitination	EKSGLGAKIPVTIIT HHCCCCCCCCEEEEE	45.83	21890473
55	Ubiquitination	TGYLGAGKTTLLNYI ECCCCCCHHHHHHHH	37.49	-
55	Ubiquitination	TGYLGAGKTTLLNYI ECCCCCCHHHHHHHH	37.49	21890473
55	Ubiquitination	TGYLGAGKTTLLNYI ECCCCCCHHHHHHHH	37.49	21906983
69	Ubiquitination	ILTEQHSKRVAVILN HHCCCCCCEEEEEEC	49.09	21890473
69	Ubiquitination	ILTEQHSKRVAVILN HHCCCCCCEEEEEEC	49.09	21890473
69	Ubiquitination	ILTEQHSKRVAVILN HHCCCCCCEEEEEEC	49.09	21890473
78	Phosphorylation	VAVILNESGEGSALE EEEEECCCCCCCHHH	40.86	24114839
82	Phosphorylation	LNESGEGSALEKSLA ECCCCCCCHHHHHEE	25.94	24114839
91	Phosphorylation	LEKSLAVSQGGELYE HHHHEEECCCCHHHH	19.94	-
97	Phosphorylation	VSQGGELYEEWLELR ECCCCHHHHHHHHHH	13.90	-
113	Ubiquitination	GCLCCSVKDNGLRAI CCEEEEECHHHHHHH	29.23	-
113	Ubiquitination	GCLCCSVKDNGLRAI CCEEEEECHHHHHHH	29.23	-
126	Ubiquitination	AIENLMQKKGKFDDI HHHHHHHHCCCCCHH	49.91	21890473
126	Ubiquitination	AIENLMQKKGKFDDI HHHHHHHHCCCCCHH	49.91	2190698
126	Ubiquitination	AIENLMQKKGKFDDI HHHHHHHHCCCCCHH	49.91	21890473
127	Ubiquitination	IENLMQKKGKFDDIL HHHHHHHCCCCCHHH	50.90	-
156	Ubiquitination	MFWVDAELGSDIYLD EEEEEHHHCCCEEEC	9.49	21890473
162	Ubiquitination	ELGSDIYLDGIITIV HHCCCEEECCEEEEE	5.06	21890473
176	Ubiquitination	VDSKYGLKHLTEEKP EECCCCHHHCCCCCC	32.00	21890473
182	Ubiquitination	LKHLTEEKPDGLINE HHHCCCCCCCCHHCH	42.02	21890473
194	Ubiquitination	INEATRQVALADIIL HCHHHHHHHHHHEEE	4.20	21890473
214	Ubiquitination	LVPEEDVKKLRTTIR CCCHHHHHHHHHHHH	59.41	21890473
222	Phosphorylation	KLRTTIRSINGLGQI HHHHHHHHHCCHHHH	19.29	27251275
232	Phosphorylation	GLGQILETQRSRVDL CHHHHHHHHHHCCCH	26.32	27251275
235	Phosphorylation	QILETQRSRVDLSNV HHHHHHHHCCCHHHH	27.17	27251275
238	Ubiquitination	ETQRSRVDLSNVLDL HHHHHCCCHHHHCCH	43.18	21890473
255	Phosphorylation	FDSLSGISLQKKLQH HHCCCCCCHHHHHHC	28.42	24719451
258	Ubiquitination	LSGISLQKKLQHVPG CCCCCHHHHHHCCCC	61.82	21890473
301	Ubiquitination	IQNLLWEKNVRNKDN HHHHHHHHHCCCCCC	49.51	-
305	Ubiquitination	LWEKNVRNKDNHCME HHHHHCCCCCCCHHH	52.31	21890473
306	Ubiquitination	WEKNVRNKDNHCMEV HHHHCCCCCCCHHHE	49.71	-
317	Ubiquitination	CMEVIRLKGLVSIKD HHHEEEEEEEEECCC	40.11	-
323	Ubiquitination	LKGLVSIKDKSQQVI EEEEEECCCCCCEEE	52.15	-
325	Ubiquitination	GLVSIKDKSQQVIVQ EEEECCCCCCEEEEE	45.20	21890473
328	Ubiquitination	SIKDKSQQVIVQGVH ECCCCCCEEEEEECE	33.71	21890473
338	Phosphorylation	VQGVHELYDLEETPV EEECEEEECCCCCCC	18.59	27642862
348	Ubiquitination	EETPVSWKDDTERTN CCCCCCCCCCCCCCC	37.91	21890473
350	Ubiquitination	TPVSWKDDTERTNRL CCCCCCCCCCCCCEE	46.90	21890473
366	Ubiquitination	LIGRNLDKDILKQLF EEECCCCHHHHHHHH	50.24	-
370	Ubiquitination	NLDKDILKQLFIATV CCCHHHHHHHHHCCC	45.34	21890473
370	Ubiquitination	NLDKDILKQLFIATV CCCHHHHHHHHHCCC	45.34	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBWD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBWD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBWD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CBWD3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.