CBPC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBPC4_HUMAN
• UniProt AC: Q96MI9
• Protein Name: Cytosolic carboxypeptidase 4
• Gene Name: AGBL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1066
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5..
• Protein Sequence: MISKGGSEALLQTLVDTARTAPPDYDILLPLFRLLAKVGLRDKKIGRKALELEALDVTLILARKNLSHGQNLLHCLWALRVFASSVSMGAMLGINGAMELLFKVITPYTRKRTQAIRAATEVLAALLKSKSNGRRAVNRGYVTSLLGLHQDWHSHDTANAYVQIRRGLLLCLRHIAALRSGREAFLAAQGMEILFSTTQNCLDDKSMEPVISVVLQILRQCYPTSPLPLVTASSAYAFPVPGCITTEPPHDLPEEDFEDDGDDEVDKDSDTEDGKVEDDDLETDVNKLSSKPGLDRPEEELMQYEVMCLELSYSFEELQSKLGDDLNSEKTQYANHHHIPAAASSKQHCYSKDQSSCGQEREYAVQTSLLCRVKTGRSTVHLGSKKNPGVNLYQNVQSNSLRRDSSESEIPDIQASPKADAWDVDAIFCPRMSASFSNSTRTREVVKVIDKLLQTHLKRVPFHDPYLYMAKARRTSSVVDFKMMAFPDVWGHCPPPTTQPMLERKCGVQRIRIFEDIRRLIQPSDVINKVVFSLDEPWPLQDNASNCLRFFSKFESGNLRKAIQVREFEYDLLVNADVNSTQHQQWFYFKVSGMQAAIPYHFNIINCEKPNSQFNYGMQPTLYSVKEALLGKPTWIRTGHEICYYKNHYRQSTAVAGGASGKCYYTLTFAVTFPHSEDVCYLAYHYPYTYTALMTHLDILEKSVNLKEVYFRQDVLCQTLGGNPCPLVTITAMPESNSDEHLEQFRHRPYQVITARVHPGESNASWVMKGTLEFLVSSDPVARLLRENFIFKIIPMLNPDGVINGNHRCSLSGEDLNRQWLSPSAHLQPTIYHAKGLLYHLSSIGRSPVVFCDFHGHSQKKNVFLYGCSIKETLWQAACTVGTSTILEEVNYRTLPKILDKLAPAFTMSSCSFLVEKSRASTARVVVWREMGVSRSYTMESSYCGCNQGPYQCTQRLLERTKNERAHPVDGLQGLQFGTRELEEMGAMFCLGLLILELKSASCSHQLLAQAATLLSAEEDALDQHLQRLKSSNFLPKHIWFAYHFFAITNFFKMNLLLHVSPVCDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	VLAALLKSKSNGRRA HHHHHHHCCCCCCCC	41.09	24850871
154	Phosphorylation	GLHQDWHSHDTANAY CCCCCCCCCCCHHHH	20.85	23898821
157	Phosphorylation	QDWHSHDTANAYVQI CCCCCCCCHHHHHHH	19.18	23898821
368	Phosphorylation	REYAVQTSLLCRVKT HHHHHHHHHEEEEEC	11.40	46160285
375	Phosphorylation	SLLCRVKTGRSTVHL HHEEEEECCCCEEEE	34.66	28152594
378	Phosphorylation	CRVKTGRSTVHLGSK EEEECCCCEEEECCC	35.81	28152594
379	Phosphorylation	RVKTGRSTVHLGSKK EEECCCCEEEECCCC	15.58	28152594
384	Phosphorylation	RSTVHLGSKKNPGVN CCEEEECCCCCCCCC	46.98	28152594
405	Phosphorylation	SNSLRRDSSESEIPD CCCCCCCCCCCCCCC	33.91	22673903
406	Phosphorylation	NSLRRDSSESEIPDI CCCCCCCCCCCCCCC	49.81	22673903
408	Phosphorylation	LRRDSSESEIPDIQA CCCCCCCCCCCCCCC	42.65	22673903
416	Phosphorylation	EIPDIQASPKADAWD CCCCCCCCCCCCCCC	15.57	22673903
552	Phosphorylation	SNCLRFFSKFESGNL HHHHHHHHHCCCCCH	33.45	23532336
842	Phosphorylation	KGLLYHLSSIGRSPV HHHHHHHHHCCCCCE	13.44	46160291
954	Phosphorylation	NQGPYQCTQRLLERT CCCHHHHHHHHHHHH	10.95	50563927

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBPC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBPC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBPC4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CBPC4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.