CBF5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBF5_SCHPO
• UniProt AC: O14007
• Protein Name: H/ACA ribonucleoprotein complex subunit cbf5 {ECO:0000305}
• Gene Name: cbf5
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 474
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs..
• Protein Sequence: MTDTHPGVDFMIKPEATSASKIDTAEWPLLLKNFDKLLVRTGHYTPIPCGNNPLKRPIAEYVSSGVINLDKPANPSSHEVVAWVKKILRVEKTGHSGTLDPKVTGCLIICNDRATRLVKSQQSAGKEYVCVLRLHDSVEGERNVASAIETLTGALFQRPPLISAVKRQLRIRSIYESKLIEFDNERNLAVFWASCEAGTYMRTLCVHLGLLLGVGGHMQELRRVRSGCLSENDDIVTMHDVLDAQWIYDNTRDESYLRRVIRPLESLLVGYKRIVVKDSAVNAICYGAKLMIPGLLRYEAGIEVNEEIVLITTKGEAIAVGIAQMSTVELSTCDHGVVAKVKRCIMERDVYPRRWGLGPQSMKKKTLKKEGKLDKYGRPNENTPADWSKSYIDYSDPNAEVAKPAPVVAPAAPTVEAEVNGVEDSKKRKSVESSEKDEDEAAKKEEKRRKKEAKKEKKEKKEKKEKKEKKKKSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	MIKPEATSASKIDTA EECCCCCCHHHCCCC	37.28	24763107
388	Phosphorylation	ENTPADWSKSYIDYS CCCCCCHHHHHCCCC	16.57	24763107
395	Phosphorylation	SKSYIDYSDPNAEVA HHHHCCCCCCCCCCC	42.73	27738172
430	Phosphorylation	EDSKKRKSVESSEKD CCHHHHHCCCCCHHH	34.84	24763107
433	Phosphorylation	KKRKSVESSEKDEDE HHHHCCCCCHHHHHH	41.46	21712547
434	Phosphorylation	KRKSVESSEKDEDEA HHHCCCCCHHHHHHH	34.85	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBF5_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBF5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBF5_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of CBF5_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.