CAZA2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAZA2_RAT
• UniProt AC: Q3T1K5
• Protein Name: F-actin-capping protein subunit alpha-2
• Gene Name: Capza2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 286
• Protein Description: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity)..
• Protein Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADLEEQLS ------CCCHHHHCC	30.05	-
9	Phosphorylation	ADLEEQLSDEEKVRI CCHHHHCCHHHHHHH	42.54	23298284
86	Acetylation	HGDLGNGKFLDPKNR CCCCCCCCCCCCCCC	46.91	25786129
97	Acetylation	PKNRICFKFDHLRKE CCCCEEEEHHHHHHC	45.53	22902405
180	Phosphorylation	WRSEWKFTVTPSTTQ CCCEEEEEECCCCEE	21.53	25575281
182	Phosphorylation	SEWKFTVTPSTTQVV CEEEEEECCCCEEEE	14.41	25575281
184	Phosphorylation	WKFTVTPSTTQVVGI EEEEECCCCEEEEEE	34.42	25575281
185	Phosphorylation	KFTVTPSTTQVVGIL EEEECCCCEEEEEEE	23.58	25575281
186	Phosphorylation	FTVTPSTTQVVGILK EEECCCCEEEEEEEE	24.57	25575281
226	Acetylation	SNEVQTAKEFIKIVE CHHHHHHHHHHHHHH	57.45	22902405
273	Acetylation	RTKIDWNKILSYKIG CCEECHHHHHHHHCH	40.55	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAZA2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAZA2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAZA2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CAZA2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.