CAZA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAZA1_RAT
• UniProt AC: B2GUZ5
• Protein Name: F-actin-capping protein subunit alpha-1 {ECO:0000250|UniProtKB:P52907}
• Gene Name: Capza1 {ECO:0000250|UniProtKB:P52907}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 286
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions..
• Protein Sequence: MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYDDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEDVDGGLKSWRDSCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEVQTAKEFIKIIESAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADFEDRVS ------CCCHHHCCC	30.14	-
9	Phosphorylation	ADFEDRVSDEEKVRI CCHHHCCCHHHHHHH	39.95	22673903
19	Acetylation	EKVRIAAKFITHAPP HHHHHHHHHHHCCCC	28.42	22902405
57	Phosphorylation	AAHAFAQYNMDQFTP HHHHHHHCCHHHCCC	14.71	30181290
63	Phosphorylation	QYNMDQFTPVKIEGY HCCHHHCCCEEEECC	22.87	30181290
97	Acetylation	PRNKISFKFDHLRKE CCCCEEEEHHHHHHC	42.99	22902405
118	Acetylation	EDVDGGLKSWRDSCD CCCCCCHHHHHHHHH	51.77	22902405
273	Acetylation	RTKIDWNKILSYKIG CCEECHHHHHHHHCH	40.55	59136979
273	Ubiquitination	RTKIDWNKILSYKIG CCEECHHHHHHHHCH	40.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAZA1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAZA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAZA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CAZA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.