CATW_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CATW_HUMAN
• UniProt AC: P56202
• Protein Name: Cathepsin W
• Gene Name: CTSW
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Protein Description: May have a specific function in the mechanism or regulation of T-cell cytolytic activity..
• Protein Sequence: MALTAHPSCLLALLVAGLAQGIRGPLRAQDLGPQPLELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGITKFPLTARVQKPDMKPRVSCPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	GPQPLELKEAFKLFQ CCCCCCHHHHHHHHC	37.31	29967540
50	N-linked_Glycosylation	KLFQIQFNRSYLSPE HHHCCCCCHHHCCHH	18.66	UniProtKB CARBOHYD
114	Phosphorylation	RAAGGVPSMGREIRS HHCCCCCCCCCCCCC	31.31	27174698
136	Acetylation	PFSCDWRKVASAISP CCCCCHHHHHHHHCC	37.59	25953088
142	Phosphorylation	RKVASAISPIKDQKN HHHHHHHCCCCCCCC	21.93	25003641
145	Acetylation	ASAISPIKDQKNCNC HHHHCCCCCCCCCCC	58.45	25953088
148	Ubiquitination	ISPIKDQKNCNCCWA HCCCCCCCCCCCHHH	73.86	-
205	N-linked_Glycosylation	DAFITVLNNSGLASE HCCEEEECCCCCCCC	35.96	UniProtKB CARBOHYD
220	Ubiquitination	KDYPFQGKVRAHRCH CCCCCCCCEEEECCC	20.12	20639865
311	O-linked_Glycosylation	EEGIWAETVSSQSQP CCCEEEEECCCCCCC	20.24	OGP
316	O-linked_Glycosylation	AETVSSQSQPQPPHP EEECCCCCCCCCCCC	45.86	OGP
324	O-linked_Glycosylation	QPQPPHPTPYWILKN CCCCCCCCCEEEEEC	26.44	OGP
340	Ubiquitination	WGAQWGEKGYFRLHR CCCCCCCCCCEEEEC	55.78	-
356	Ubiquitination	SNTCGITKFPLTARV CCCCCCEECCEEEEC	42.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CATW_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CATW_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CATW_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CATW_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.