CATIN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CATIN_MOUSE
• UniProt AC: Q9CS00
• Protein Name: Cactin
• Gene Name: Cactin
• Organism: Mus musculus (Mouse).
• Sequence Length: 772
• Subcellular Localization: Nucleus. Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus (By similarity)..
• Protein Description: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing (By similarity)..
• Protein Sequence: MRGAGRQMGRDSRSRSRSVGRRGRKQRSRSRGRSRSRSRSRSRSRSRSRSRSRSHGRSSRRRREHERRRERKRRSRGRRSDSEGEQRQKSRRRSQSLRPPRWHSQNQSSCSDSGEERAQGSWARKGHRRSWSPGSSASSLDSPRRSRSPGTATLALSQQQSLQERLRLREERKQQEELLKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFGDNNLLGTFIWNKALEKKGISHLEEKELKERNKRIQEDNRLELQKVKQLRLEREREKAMREQELELLQREKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNVDFWRDMTTITEDEIAKLRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLFKLKQEQGVESEPLFPILKSEPSAAHSPEPEERPPSPGTSVDPVEPVEPEEATAPGEAEGEAEGEAVLMEEDLIQQSLADYDAGRYSPRLLTAHELPLDAHVLEPHEDLQRLQLSRQQLQATGDASESAEDIFFRRAREGMGQDEAQFSVEMPLGGRAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAGPPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	GRDSRSRSRSVGRRG CCCCHHHHHHHHHHH		23737553
18	Phosphorylation	DSRSRSRSVGRRGRK CCHHHHHHHHHHHHH		23737553
80	Phosphorylation	RRSRGRRSDSEGEQR HHHHCCCCCCHHHHH		27087446
82	Phosphorylation	SRGRRSDSEGEQRQK HHCCCCCCHHHHHHH		27087446
91	Methylation	GEQRQKSRRRSQSLR HHHHHHHHHHHHHCC		-
94	Phosphorylation	RQKSRRRSQSLRPPR HHHHHHHHHHCCCCC		22817900
96	Phosphorylation	KSRRRSQSLRPPRWH HHHHHHHHCCCCCHH		25263469
108	Phosphorylation	RWHSQNQSSCSDSGE CHHCCCCCCCCCCHH		23684622
109	Phosphorylation	WHSQNQSSCSDSGEE HHCCCCCCCCCCHHH		23684622
111	Phosphorylation	SQNQSSCSDSGEERA CCCCCCCCCCHHHHH		23684622
113	Phosphorylation	NQSSCSDSGEERAQG CCCCCCCCHHHHHCC		23684622
121	Phosphorylation	GEERAQGSWARKGHR HHHHHCCCHHCCCCC		27149854
130	Phosphorylation	ARKGHRRSWSPGSSA HCCCCCCCCCCCCCC		22817900
132	Phosphorylation	KGHRRSWSPGSSASS CCCCCCCCCCCCCHH		22817900
142	Phosphorylation	SSASSLDSPRRSRSP CCCHHCCCCCCCCCC		23384938
146	Phosphorylation	SLDSPRRSRSPGTAT HCCCCCCCCCCCCHH		25521595
148	Phosphorylation	DSPRRSRSPGTATLA CCCCCCCCCCCHHHH		25521595
151	Phosphorylation	RRSRSPGTATLALSQ CCCCCCCCHHHHHHH		21082442
153	Phosphorylation	SRSPGTATLALSQQQ CCCCCCHHHHHHHHH		27566939
157	Phosphorylation	GTATLALSQQQSLQE CCHHHHHHHHHHHHH		28833060
161	Phosphorylation	LALSQQQSLQERLRL HHHHHHHHHHHHHHH		28833060
244	Phosphorylation	ALEKKGISHLEEKEL HHHHCCCCHHHHHHH		25338131
252	Acetylation	HLEEKELKERNKRIQ HHHHHHHHHHHHHHH		15621821
498	Phosphorylation	KQEQGVESEPLFPIL HHHHCCCCCCCCHHH		25338131
507	Phosphorylation	PLFPILKSEPSAAHS CCCHHHHCCCCCCCC		21189417
510	Phosphorylation	PILKSEPSAAHSPEP HHHHCCCCCCCCCCC		21189417
514	Phosphorylation	SEPSAAHSPEPEERP CCCCCCCCCCCCCCC		25338131
523	Phosphorylation	EPEERPPSPGTSVDP CCCCCCCCCCCCCCC		25338131
526	Phosphorylation	ERPPSPGTSVDPVEP CCCCCCCCCCCCCCC		20531401
527	Phosphorylation	RPPSPGTSVDPVEPV CCCCCCCCCCCCCCC		20531401
540	Phosphorylation	PVEPEEATAPGEAEG CCCHHHCCCCCCCCC		20531401
573	Phosphorylation	ADYDAGRYSPRLLTA CCCCCCCCCCCCEEE		21189417

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CATIN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CATIN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CATIN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CATIN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.