CASS4_HUMAN - dbPTM
CASS4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CASS4_HUMAN
UniProt AC Q9NQ75
Protein Name Cas scaffolding protein family member 4
Gene Name CASS4
Organism Homo sapiens (Human).
Sequence Length 786
Subcellular Localization Cytoplasm, cytoskeleton . Cell junction, focal adhesion .
Protein Description Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading..
Protein Sequence MKGTGIMDCAPKALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQILTEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGPQPPTAQVYEFPDPPTSARIICEKTLSFPKQAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRGGYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRGTFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASIVSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARGVHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFKRNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQAEAEKLEQHTRQFRGTLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MKGTGIMDCAP
----CCCCCCCCCCH		20.30-
93PhosphorylationGLEEAPASSEETYQV
CCCCCCCCCCCCCCC		36.9028060719
94PhosphorylationLEEAPASSEETYQVP
CCCCCCCCCCCCCCC		41.3728060719
97PhosphorylationAPASSEETYQVPTLP
CCCCCCCCCCCCCCC		18.4028060719
98PhosphorylationPASSEETYQVPTLPR
CCCCCCCCCCCCCCC		15.7028060719
102PhosphorylationEETYQVPTLPRPPTP
CCCCCCCCCCCCCCC		51.0026434776
108PhosphorylationPTLPRPPTPGPVYEQ
CCCCCCCCCCHHHHH		43.4928060719
113PhosphorylationPPTPGPVYEQMRSWA
CCCCCHHHHHHHHHH		11.9928060719
118PhosphorylationPVYEQMRSWAEGPQP
HHHHHHHHHHCCCCC		25.87-
127PhosphorylationAEGPQPPTAQVYEFP
HCCCCCCCCEEEECC		36.08-
131PhosphorylationQPPTAQVYEFPDPPT
CCCCCEEEECCCCCC		10.3622817900
149PhosphorylationIICEKTLSFPKQAIL
EEEECCCCCCCCEEE		44.74-
157PhosphorylationFPKQAILTLPRPVRA
CCCCEEECCCCCCCC		28.7126434776
165PhosphorylationLPRPVRASLPTLPSQ
CCCCCCCCCCCCCHH		25.0724719451
171PhosphorylationASLPTLPSQVYDVPT
CCCCCCCHHCCCCCC		35.0824719451
174PhosphorylationPTLPSQVYDVPTQHR
CCCCHHCCCCCCCCC		12.0025884760
178PhosphorylationSQVYDVPTQHRGPVV
HHCCCCCCCCCCCEE		36.5326356563
195PhosphorylationEPEKQQLYDIPASPK
CCCCCCCCCCCCCCC		13.9021082442
200PhosphorylationQLYDIPASPKKAGLH
CCCCCCCCCCCCCCC		31.7123401153
211 (in isoform 3)Phosphorylation-33.16-
214 (in isoform 3)Phosphorylation-24.82-
222PhosphorylationGQGVPLISVTTLRRG
CCCCCEEEEEEEECC		22.5428060719
224PhosphorylationGVPLISVTTLRRGGY
CCCEEEEEEEECCCC		17.2128060719
225PhosphorylationVPLISVTTLRRGGYS
CCEEEEEEEECCCCC		18.9928060719
231PhosphorylationTTLRRGGYSTLPNPQ
EEEECCCCCCCCCCC		10.9928060719
232PhosphorylationTLRRGGYSTLPNPQK
EEECCCCCCCCCCCC		27.0929970186
233PhosphorylationLRRGGYSTLPNPQKS
EECCCCCCCCCCCCC		37.4428060719
244PhosphorylationPQKSEWIYDTPVSPG
CCCCCCCCCCCCCCC		18.1621082442
246PhosphorylationKSEWIYDTPVSPGKA
CCCCCCCCCCCCCCC		14.4926356563
249PhosphorylationWIYDTPVSPGKASVR
CCCCCCCCCCCCCCC		29.1929970186
274PhosphorylationSRPHALPSSSSTFYN
CCCCCCCCCCCCCCC		43.64-
280PhosphorylationPSSSSTFYNPPSGRS
CCCCCCCCCCCCCCC		27.1822817900
287PhosphorylationYNPPSGRSRSLTPQL
CCCCCCCCCCCCHHC		29.7328857561
289PhosphorylationPPSGRSRSLTPQLNN
CCCCCCCCCCHHCCC		37.5328857561
291PhosphorylationSGRSRSLTPQLNNNV
CCCCCCCCHHCCCCC		15.3828857561
305PhosphorylationVPMQKKLSLPEIPSY
CCCCCCCCCCCCCCC		51.2423898821
311PhosphorylationLSLPEIPSYGFLVPR
CCCCCCCCCCEEEEC		43.4828450419
312PhosphorylationSLPEIPSYGFLVPRG
CCCCCCCCCEEEECC		13.4228060719
328PhosphorylationFPLDEDVSYKVPSSF
CCCCCCCCCCCCHHH		31.4019060867
329PhosphorylationPLDEDVSYKVPSSFL
CCCCCCCCCCCHHHC		18.8222817900
345PhosphorylationPRVEQQNTKPNIYDI
CCHHCCCCCCCCCCC		43.4729978859
350PhosphorylationQNTKPNIYDIPKATS
CCCCCCCCCCHHHCC		17.9225884760
376PhosphorylationAKEVSENSAGHNSSW
HHHHHHCCCCCCCCC		31.4123917254
388PhosphorylationSSWFSRRTTSPSPEP
CCCHHCCCCCCCCCC		30.4328060719
389PhosphorylationSWFSRRTTSPSPEPD
CCHHCCCCCCCCCCC		36.5128060719
390PhosphorylationWFSRRTTSPSPEPDR
CHHCCCCCCCCCCCC		23.8328060719
392PhosphorylationSRRTTSPSPEPDRLS
HCCCCCCCCCCCCCC		41.4828060719
399PhosphorylationSPEPDRLSGSSSDSR
CCCCCCCCCCCCCCC		37.2128060719
401PhosphorylationEPDRLSGSSSDSRAS
CCCCCCCCCCCCCHH		24.2428060719
402PhosphorylationPDRLSGSSSDSRASI
CCCCCCCCCCCCHHH		41.5128060719
403PhosphorylationDRLSGSSSDSRASIV
CCCCCCCCCCCHHHH		41.1028060719
408PhosphorylationSSSDSRASIVSSCST
CCCCCCHHHHHCCCC		23.5528270605
411PhosphorylationDSRASIVSSCSTTST
CCCHHHHHCCCCCCC		24.7728270605
412PhosphorylationSRASIVSSCSTTSTD
CCHHHHHCCCCCCCC		10.9528270605
414PhosphorylationASIVSSCSTTSTDDS
HHHHHCCCCCCCCCC		36.3528270605
415PhosphorylationSIVSSCSTTSTDDSS
HHHHCCCCCCCCCCC		29.1528270605
416PhosphorylationIVSSCSTTSTDDSSS
HHHCCCCCCCCCCCC		17.2128270605
417PhosphorylationVSSCSTTSTDDSSSS
HHCCCCCCCCCCCCC		29.9028270605
418PhosphorylationSSCSTTSTDDSSSSS
HCCCCCCCCCCCCCC		41.5628270605
421PhosphorylationSTTSTDDSSSSSSEE
CCCCCCCCCCCCCHH		34.6228270605
422PhosphorylationTTSTDDSSSSSSEES
CCCCCCCCCCCCHHH		41.0328270605
423PhosphorylationTSTDDSSSSSSEESA
CCCCCCCCCCCHHHH		37.8928270605
424PhosphorylationSTDDSSSSSSEESAK
CCCCCCCCCCHHHHH		39.5728270605
425PhosphorylationTDDSSSSSSEESAKE
CCCCCCCCCHHHHHH		43.6528270605
426PhosphorylationDDSSSSSSEESAKEL
CCCCCCCCHHHHHHH		47.5328270605
429PhosphorylationSSSSSEESAKELSLD
CCCCCHHHHHHHCCC		40.3628270605
434PhosphorylationEESAKELSLDLDVAK
HHHHHHHCCCHHHHH		22.41-
463PhosphorylationAGLMLFVSRKWRFRD
HHHHHHHHCCHHHHH		22.32-
508PhosphorylationHGTACNLTDSNLQNR
CCCHHCCCCHHHHHH		24.3228270605
510PhosphorylationTACNLTDSNLQNRIR
CHHCCCCHHHHHHHH		33.9228270605
549PhosphorylationWPLEVLVTDSVQNSP
CCEEEEEEECCCCCH		20.5628060719
551PhosphorylationLEVLVTDSVQNSPDD
EEEEEEECCCCCHHH		19.0828060719
555PhosphorylationVTDSVQNSPDDLERF
EEECCCCCHHHHHHH		16.7728060719
597PhosphorylationRNCEKEETVQLTPNA
CCCCCCCEEECCCCC		18.0430576142
601PhosphorylationKEETVQLTPNAEFKC
CCCEEECCCCCEEEE		9.4528060719
679PhosphorylationLSEHCRLYFGALFKA
HHHHHHHHHHHHHHH		4.8022817900
742PhosphorylationRGSSHLCSLLKDVAL
HCHHHHHHHHHHHHH		43.0024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CASS4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CASS4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CASS4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MICA1_HUMANMICAL1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CASS4_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-249; SER-305AND SER-390, AND MASS SPECTROMETRY.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-329 AND TYR-350, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory