CASD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASD1_HUMAN
• UniProt AC: Q96PB1
• Protein Name: N-acetylneuraminate 9-O-acetyltransferase {ECO:0000305}
• Gene Name: CASD1 {ECO:0000312|HGNC:HGNC:16014}
• Organism: Homo sapiens (Human).
• Sequence Length: 797
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. [PubMed: 20947662]
• Protein Sequence: MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKTASVKVDFLWHPEVNGSMKQCIKVWTEDSIAKPHVIVAGAATWSIKIHNGSSEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRETTAMILMNVYCNKILKPVDGSCCQPRPPVTLIQKLAACFFTLSIIGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIYRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQIIQKKANGNCFWHFGLLLKLGFLLLFICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSNKISNFLLFISVVSFLTYSIWASSCKNKAECNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	N-linked_Glycosylation	ASRRYRGNDSCEYLL HHHHHCCCCHHHHHH	29.08	-
131	Acetylation	EDKTASVKVDFLWHP CCCCEEEEEEEEECC	33.32	7427861
155	Phosphorylation	IKVWTEDSIAKPHVI HHHHCCCCCCCCEEE	20.43	-
175	N-linked_Glycosylation	TWSIKIHNGSSEALS EEEEEEECCCHHHHH	56.36	-
182	Phosphorylation	NGSSEALSQYKMNIT CCCHHHHHHHCCCHH	38.21	24719451
187	N-linked_Glycosylation	ALSQYKMNITSIAPL HHHHHCCCHHHHHHH	30.18	-
232	Phosphorylation	TNEKIDAYNEAAVSI HHHHHHHHHHHHHHH	15.13	-
290	Phosphorylation	AMILMNVYCNKILKP HHHHHHHHHCCCCCC	5.82	27067055
345	Phosphorylation	HRKNKPCTDLESGEE HHCCCCCCCCCCCHH	52.74	25332170
349	Phosphorylation	KPCTDLESGEEKKNI CCCCCCCCCHHHHCC	59.82	28348404
380	Phosphorylation	KLGLIMAYFYMCDRA HHHHHHHHHHHHHHH	4.28	-
382	Phosphorylation	GLIMAYFYMCDRANL HHHHHHHHHHHHHHH	5.55	-
457	Phosphorylation	ASTFLPVYMHIRVLV HHCHHHHHHHHHHHH	4.88	22210691
770	Phosphorylation	IIPKDNSSLLKRLAC HCCCCCHHHHHHHHH	43.93	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CASD1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.