| UniProt ID | CARL2_HUMAN | |
|---|---|---|
| UniProt AC | Q6F5E8 | |
| Protein Name | Capping protein, Arp2/3 and myosin-I linker protein 2 {ECO:0000303|PubMed:19846667} | |
| Gene Name | CARMIL2 {ECO:0000312|HGNC:HGNC:27089} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1435 | |
| Subcellular Localization |
Isoform 2: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane Peripheral membrane protein Cytoplasmic side . Cell projection, lamellipodium . Cell projection, ruffle . Colocalizes to dynamic vimentin filaments both in the central cytoplasm and a |
|
| Protein Description | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. [PubMed: 26466680 Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations] | |
| Protein Sequence | MAQTPDGISCELRGEITRFLWPKEVELLLKTWLPGEGAVQNHVLALLRWRAYLLHTTCLPLRVDCTFSYLEVQAMALQETPPQVTFELESLRELVLEFPGVAALEQLAQHVAAAIKKVFPRSTLGKLFRRPTPASMLARLERSSPSESTDPCSPCGGFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFSLGDFSHLGSRDLALSVAALSYNLWFRCLSCVDMKLSLEVSEQILHMMSQSSHLEELVLETCSLRGDFVRRLAQALAGHSSSGLRELSLAGNLLDDRGMTALSRHLERCPGALRRLSLAQTGLTPRGMRALGRALATNAAFDSTLTHLDLSGNPGALGASEDSGGLYSFLSRPNVLSFLNLAGTDTALDTVRGCSVGGWMTGRADWRAGRGGLGPPAGVANSLPPQLFAAVSRGCCTSLTHLDASRNVFSRTKSRAAPAALQLFLSRARTLRHLGLAGCKLPPDALRALLDGLALNTHLRDLHLDLSACELRSAGAQVIQDLVCDAGAVSSLDLADNGFGSDMVTLVLAIGRSRSLRHVALGRNFNVRCKETLDDVLHRIVQLMQDDDCPLQSLSVAESRLKLGASVLLRALATNPNLTALDISGNAMGDAGAKLLAKALRVNSRLRSVVWDRNHTSALGLLDVAQALEQNHSLKAMPLPLNDVAQAQRSRPELTARAVHQIQACLLRNNRADPASSDHTTRLQPLGLVSDPSEQEVNELCQSVQEHVELLGCGAGPQGEAAVRQAEDAIQNANFSLSILPILYEAGSSPSHHWQLGQKLEGLLRQVGEVCRQDIQDFTQATLDTARSLCPQMLQGSSWREQLEGVLAGSRGLPELLPEQLLQDAFTRLRDMRLSITGTLAESIVAQALAGLSAARDQLVESLAQQATVTMPPALPAPDGGEPSLLEPGELEGLFFPEEKEEEKEKDDSPPQKWPELSHGLHLVPFIHSAAEEAEPEPELAAPGEDAEPQAGPSARGSPSPAAPGPPAGPLPRMDLPLAGQPLRHPTRARPRPRRQHHHRPPPGGPQVPPALPQEGNGLSARVDEGVEEFFSKRLIQQDRLWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRTDLETSPGAAPRTRKTTFGDLLRPPTRPSRGEELGGAEGDTSSPDPAGRSRPRYTRDSKAYSMILLPAEEEATLGARPDKRRPLERGETELAPSFEQRVQVMLQRIGVSRGSGGAEGKRKQSKDGEIKKAGSDGDIMDSSTEAPPISIKSRTHSVSADPSCRPGPGSQGPESATWKTLGQQLNAELRSRGWGQQDGPGPPSPGQSPSPCRTSPSPDSLGLPEDPCLGPRNEDGQLRPRPLSAGRRAVSVHEDQLQAPAERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGTEPLPPQPTEPSSPERSPPSPATDQRGGGPNP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Ubiquitination | ITRFLWPKEVELLLK EECCCCHHHHHHHHH | - | ||
| 23 | Ubiquitination | ITRFLWPKEVELLLK EECCCCHHHHHHHHH | - | ||
| 126 | Methylation | FPRSTLGKLFRRPTP CCHHHHHHHHCCCCH | - | ||
| 126 | Ubiquitination | FPRSTLGKLFRRPTP CCHHHHHHHHCCCCH | - | ||
| 126 | Methylation | FPRSTLGKLFRRPTP CCHHHHHHHHCCCCH | 23644510 | ||
| 126 | Ubiquitination | FPRSTLGKLFRRPTP CCHHHHHHHHCCCCH | - | ||
| 132 | Phosphorylation | GKLFRRPTPASMLAR HHHHCCCCHHHHHHH | 23532336 | ||
| 135 | Phosphorylation | FRRPTPASMLARLER HCCCCHHHHHHHHHH | - | ||
| 183 | Phosphorylation | EIQWDVDTIYHRQGC HEECCCCHHHHCCCC | - | ||
| 185 | Phosphorylation | QWDVDTIYHRQGCRH ECCCCHHHHCCCCCC | - | ||
| 194 | Phosphorylation | RQGCRHFSLGDFSHL CCCCCCCCCCCCCCC | 30108239 | ||
| 199 | Phosphorylation | HFSLGDFSHLGSRDL CCCCCCCCCCCHHHH | 30108239 | ||
| 203 | Phosphorylation | GDFSHLGSRDLALSV CCCCCCCHHHHHHHH | 27732954 | ||
| 230 | Phosphorylation | SCVDMKLSLEVSEQI HHHCCHHCHHHHHHH | 26074081 | ||
| 234 | Phosphorylation | MKLSLEVSEQILHMM CHHCHHHHHHHHHHH | 26074081 | ||
| 242 | Phosphorylation | EQILHMMSQSSHLEE HHHHHHHHCCCCHHH | 26074081 | ||
| 244 | Phosphorylation | ILHMMSQSSHLEELV HHHHHHCCCCHHHHH | 26074081 | ||
| 245 | Phosphorylation | LHMMSQSSHLEELVL HHHHHCCCCHHHHHH | 26074081 | ||
| 310 | Phosphorylation | PGALRRLSLAQTGLT HHHHHHHHHHHHCCC | 23911959 | ||
| 314 | Phosphorylation | RRLSLAQTGLTPRGM HHHHHHHHCCCHHHH | 23911959 | ||
| 317 | Phosphorylation | SLAQTGLTPRGMRAL HHHHHCCCHHHHHHH | 24719451 | ||
| 364 | Phosphorylation | GGLYSFLSRPNVLSF CCHHHHHCCCCHHHH | 24719451 | ||
| 437 | Ubiquitination | TSLTHLDASRNVFSR CCCHHHHHCCCHHHH | - | ||
| 473 | Ubiquitination | HLGLAGCKLPPDALR HHCCCCCCCCHHHHH | - | ||
| 527 | Ubiquitination | GAVSSLDLADNGFGS CCCCCCCCCCCCCCH | - | ||
| 559 | Ubiquitination | VALGRNFNVRCKETL HHHCCCCCCCCCHHH | - | ||
| 563 | Ubiquitination | RNFNVRCKETLDDVL CCCCCCCCHHHHHHH | - | ||
| 591 | Ubiquitination | LQSLSVAESRLKLGA CCCCHHHHHHHHHCH | - | ||
| 591 | Ubiquitination | LQSLSVAESRLKLGA CCCCHHHHHHHHHCH | 29967540 | ||
| 595 | Ubiquitination | SVAESRLKLGASVLL HHHHHHHHHCHHHHH | - | ||
| 595 | Ubiquitination | SVAESRLKLGASVLL HHHHHHHHHCHHHHH | 29967540 | ||
| 627 | Ubiquitination | AMGDAGAKLLAKALR CCHHHHHHHHHHHHH | 29967540 | ||
| 631 | Ubiquitination | AGAKLLAKALRVNSR HHHHHHHHHHHHHHH | 29967540 | ||
| 632 | Ubiquitination | GAKLLAKALRVNSRL HHHHHHHHHHHHHHH | - | ||
| 641 | Phosphorylation | RVNSRLRSVVWDRNH HHHHHHHHHHCCCCC | 30576142 | ||
| 649 | Phosphorylation | VVWDRNHTSALGLLD HHCCCCCHHHHHHHH | 30576142 | ||
| 666 | Phosphorylation | QALEQNHSLKAMPLP HHHHHCCCCCCCCCC | 30576142 | ||
| 668 | Ubiquitination | LEQNHSLKAMPLPLN HHHCCCCCCCCCCHH | - | ||
| 670 | Sulfoxidation | QNHSLKAMPLPLNDV HCCCCCCCCCCHHHH | 21406390 | ||
| 688 | Phosphorylation | QRSRPELTARAVHQI HHCCHHHHHHHHHHH | 24719451 | ||
| 818 | Phosphorylation | FTQATLDTARSLCPQ HHHHHHHHHHHHCHH | 28509920 | ||
| 886 | Phosphorylation | AQALAGLSAARDQLV HHHHHHHHHHHHHHH | - | ||
| 942 | Phosphorylation | EEKEKDDSPPQKWPE HHHCCCCCCCCCCCC | 26074081 | ||
| 957 | Phosphorylation | LSHGLHLVPFIHSAA HHCCCCHHHHHHHHH | 32142685 | ||
| 987 | Phosphorylation | AEPQAGPSARGSPSP CCCCCCCCCCCCCCC | 26074081 | ||
| 991 | Phosphorylation | AGPSARGSPSPAAPG CCCCCCCCCCCCCCC | 22617229 | ||
| 993 | Phosphorylation | PSARGSPSPAAPGPP CCCCCCCCCCCCCCC | 30266825 | ||
| 1030 | Ubiquitination | RPRPRRQHHHRPPPG CCCCCCCCCCCCCCC | 24816145 | ||
| 1035 | Ubiquitination | RQHHHRPPPGGPQVP CCCCCCCCCCCCCCC | 24816145 | ||
| 1066 | Ubiquitination | GVEEFFSKRLIQQDR HHHHHHHHHHHHHCC | 24816145 | ||
| 1083 | Phosphorylation | APEEDPATEGGATPV CCCCCCCCCCCCCCC | 26074081 | ||
| 1088 | Phosphorylation | PATEGGATPVPRTLR CCCCCCCCCCCHHHH | 28985074 | ||
| 1093 | Phosphorylation | GATPVPRTLRKKLGT CCCCCCHHHHHHHCC | - | ||
| 1095 | Dimethylation | TPVPRTLRKKLGTLF CCCCHHHHHHHCCEE | - | ||
| 1095 | Methylation | TPVPRTLRKKLGTLF CCCCHHHHHHHCCEE | 24410253 | ||
| 1105 | Acetylation | LGTLFAFKKPRSTRG HCCEEEECCCCCCCC | 25953088 | ||
| 1106 | Acetylation | GTLFAFKKPRSTRGP CCEEEECCCCCCCCC | 7704367 | ||
| 1115 | O-linked_Glycosylation | RSTRGPRTDLETSPG CCCCCCCCCCCCCCC | 30379171 | ||
| 1115 | Phosphorylation | RSTRGPRTDLETSPG CCCCCCCCCCCCCCC | 27251275 | ||
| 1119 | Phosphorylation | GPRTDLETSPGAAPR CCCCCCCCCCCCCCC | 23401153 | ||
| 1120 | Phosphorylation | PRTDLETSPGAAPRT CCCCCCCCCCCCCCC | 30266825 | ||
| 1155 | Phosphorylation | LGGAEGDTSSPDPAG CCCCCCCCCCCCCCC | 28555341 | ||
| 1156 | Phosphorylation | GGAEGDTSSPDPAGR CCCCCCCCCCCCCCC | 25022875 | ||
| 1157 | Phosphorylation | GAEGDTSSPDPAGRS CCCCCCCCCCCCCCC | 22496350 | ||
| 1158 | Ubiquitination | AEGDTSSPDPAGRSR CCCCCCCCCCCCCCC | - | ||
| 1175 | Phosphorylation | YTRDSKAYSMILLPA CCCCCCCCEEEEEEH | 28796482 | ||
| 1176 | Phosphorylation | TRDSKAYSMILLPAE CCCCCCCEEEEEEHH | 29978859 | ||
| 1194 | Ubiquitination | TLGARPDKRRPLERG CCCCCCCCCCCCCCC | - | ||
| 1203 | Phosphorylation | RPLERGETELAPSFE CCCCCCCCCCCCCHH | 23401153 | ||
| 1216 | Sulfoxidation | FEQRVQVMLQRIGVS HHHHHHHHHHHHCCC | 21406390 | ||
| 1224 | Methylation | LQRIGVSRGSGGAEG HHHHCCCCCCCCCCC | 97795459 | ||
| 1226 | Phosphorylation | RIGVSRGSGGAEGKR HHCCCCCCCCCCCCC | - | ||
| 1246 | Phosphorylation | GEIKKAGSDGDIMDS CCCEECCCCCCCCCC | 23401153 | ||
| 1251 | Sulfoxidation | AGSDGDIMDSSTEAP CCCCCCCCCCCCCCC | 21406390 | ||
| 1253 | Phosphorylation | SDGDIMDSSTEAPPI CCCCCCCCCCCCCCC | 30576142 | ||
| 1254 | Phosphorylation | DGDIMDSSTEAPPIS CCCCCCCCCCCCCCE | 26552605 | ||
| 1255 | Phosphorylation | GDIMDSSTEAPPISI CCCCCCCCCCCCCEE | 26552605 | ||
| 1261 | Phosphorylation | STEAPPISIKSRTHS CCCCCCCEEEECCCE | 26552605 | ||
| 1264 | Phosphorylation | APPISIKSRTHSVSA CCCCEEEECCCEECC | 26074081 | ||
| 1266 | Phosphorylation | PISIKSRTHSVSADP CCEEEECCCEECCCC | 29978859 | ||
| 1268 | Phosphorylation | SIKSRTHSVSADPSC EEEECCCEECCCCCC | 23401153 | ||
| 1270 | Phosphorylation | KSRTHSVSADPSCRP EECCCEECCCCCCCC | 23401153 | ||
| 1274 | Phosphorylation | HSVSADPSCRPGPGS CEECCCCCCCCCCCC | 29978859 | ||
| 1281 | Phosphorylation | SCRPGPGSQGPESAT CCCCCCCCCCCCCCH | 29978859 | ||
| 1286 | Phosphorylation | PGSQGPESATWKTLG CCCCCCCCCHHHHHH | 29978859 | ||
| 1288 | Phosphorylation | SQGPESATWKTLGQQ CCCCCCCHHHHHHHH | 26552605 | ||
| 1302 | Phosphorylation | QLNAELRSRGWGQQD HHCHHHHHCCCCCCC | 23312004 | ||
| 1303 | Methylation | LNAELRSRGWGQQDG HCHHHHHCCCCCCCC | - | ||
| 1315 | Phosphorylation | QDGPGPPSPGQSPSP CCCCCCCCCCCCCCC | 23401153 | ||
| 1319 | Phosphorylation | GPPSPGQSPSPCRTS CCCCCCCCCCCCCCC | 23401153 | ||
| 1321 | Phosphorylation | PSPGQSPSPCRTSPS CCCCCCCCCCCCCCC | 22617229 | ||
| 1325 | Phosphorylation | QSPSPCRTSPSPDSL CCCCCCCCCCCCCCC | 30266825 | ||
| 1326 | Phosphorylation | SPSPCRTSPSPDSLG CCCCCCCCCCCCCCC | 30266825 | ||
| 1328 | Phosphorylation | SPCRTSPSPDSLGLP CCCCCCCCCCCCCCC | 30266825 | ||
| 1331 | Phosphorylation | RTSPSPDSLGLPEDP CCCCCCCCCCCCCCC | 30266825 | ||
| 1355 | Phosphorylation | QLRPRPLSAGRRAVS CCCCCCCCCCCCEEE | 26074081 | ||
| 1362 | Phosphorylation | SAGRRAVSVHEDQLQ CCCCCEEEECHHHCC | 23401153 | ||
| 1381 | Phosphorylation | RPLRLQRSPVLKRRP CCCHHCCCCCHHCCC | 23401153 | ||
| 1395 | Phosphorylation | PKLEAPPSPSLGSGL CCCCCCCCCCCCCCC | 27050516 | ||
| 1397 | Phosphorylation | LEAPPSPSLGSGLGT CCCCCCCCCCCCCCC | 28348404 | ||
| 1400 | Phosphorylation | PPSPSLGSGLGTEPL CCCCCCCCCCCCCCC | 30576142 | ||
| 1404 | Phosphorylation | SLGSGLGTEPLPPQP CCCCCCCCCCCCCCC | 26074081 | ||
| 1412 | Phosphorylation | EPLPPQPTEPSSPER CCCCCCCCCCCCCCC | 26074081 | ||
| 1415 | Phosphorylation | PPQPTEPSSPERSPP CCCCCCCCCCCCCCC | 28985074 | ||
| 1416 | Phosphorylation | PQPTEPSSPERSPPS CCCCCCCCCCCCCCC | 27050516 | ||
| 1420 | Phosphorylation | EPSSPERSPPSPATD CCCCCCCCCCCCCCC | 30266825 | ||
| 1423 | Phosphorylation | SPERSPPSPATDQRG CCCCCCCCCCCCCCC | 23401153 | ||
| 1426 | Phosphorylation | RSPPSPATDQRGGGP CCCCCCCCCCCCCCC | 28122231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CARL2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CARL2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CARL2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CARL2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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