CARB_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARB_ARATH
• UniProt AC: Q42601
• Protein Name: Carbamoyl-phosphate synthase large chain, chloroplastic
• Gene Name: CARB
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1187
• Subcellular Localization: Plastid, chloroplast .
• Protein Description: Involved in arginine biosynthesis. Required for mesophyll development..
• Protein Sequence: MRNHCLELSSNCSSIFASSKSNPRFSPSKLSYSTFFSRSAIYYRSKPKQASSSSSFSTFPPCLNRKSSLTHVLKPVSELADTTTKPFSPEIVGKRTDLKKIMILGAGPIVIGQACEFDYSGTQACKALREEGYEVILINSNPATIMTDPETANRTYIAPMTPELVEQVIEKERPDALLPTMGGQTALNLAVALAESGALEKYGVELIGAKLGAIKKAEDRELFKDAMKNIGLKTPPSGIGTTLDECFDIAEKIGEFPLIIRPAFTLGGTGGGIAYNKEEFESICKSGLAASATSQVLVEKSLLGWKEYELEVMRDLADNVVIICSIENIDPMGVHTGDSITVAPAQTLTDREYQRLRDYSIAIIREIGVECGGSNVQFAVNPVDGEVMIIEMNPRVSRSSALASKATGFPIAKMAAKLSVGYTLDQIPNDITRKTPASFEPSIDYVVTKIPRFAFEKFPGSQPLLTTQMKSVGESMALGRTFQESFQKALRSLECGFSGWGCAKIKELDWDWDQLKYSLRVPNPDRIHAIYAAMKKGMKIDEIYELSMVDKWFLTQLKELVDVEQYLMSGTLSEITKEDLYEVKKRGFSDKQIAFATKTTEEEVRTKRISLGVVPSYKRVDTCAAEFEAHTPYMYSSYDVECESAPNNKKKVLILGGGPNRIGQGIEFDYCCCHTSFALQDAGYETIMLNSNPETVSTDYDTSDRLYFEPLTIEDVLNVIDLEKPDGIIVQFGGQTPLKLALPIKHYLDKHMPMSLSGAGPVRIWGTSPDSIDAAEDRERFNAILDELKIEQPKGGIAKSEADALAIAKEVGYPVVVRPSYVLGGRAMEIVYDDSRLITYLENAVQVDPERPVLVDKYLSDAIEIDVDTLTDSYGNVVIGGIMEHIEQAGVHSGDSACMLPTQTIPASCLQTIRTWTTKLAKKLNVCGLMNCQYAITTSGDVFLLEANPRASRTVPFVSKAIGHPLAKYAALVMSGKSLKDLNFEKEVIPKHVSVKEAVFPFEKFQGCDVILGPEMRSTGEVMSISSEFSSAFAMAQIAAGQKLPLSGTVFLSLNDMTKPHLEKIAVSFLELGFKIVATSGTAHFLELKGIPVERVLKLHEGRPHAADMVANGQIHLMLITSSGDALDQKDGRQLRQMALAYKVPVITTVAGALATAEGIKSLKSSAIKMTALQDFFEVKNVSSLLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	PPCLNRKSSLTHVLK CCCCCCCCCCHHHHH		25368622
68	Phosphorylation	PCLNRKSSLTHVLKP CCCCCCCCCHHHHHC		25368622
70	Phosphorylation	LNRKSSLTHVLKPVS CCCCCCCHHHHHCHH		25368622
77	Phosphorylation	THVLKPVSELADTTT HHHHHCHHHHCCCCC		25368622
82	Phosphorylation	PVSELADTTTKPFSP CHHHHCCCCCCCCCH		25368622
83	Phosphorylation	VSELADTTTKPFSPE HHHHCCCCCCCCCHH		25368622
84	Phosphorylation	SELADTTTKPFSPEI HHHCCCCCCCCCHHH		25368622
234	Phosphorylation	MKNIGLKTPPSGIGT HHHCCCCCCCCCCCC		27545962
237	Phosphorylation	IGLKTPPSGIGTTLD CCCCCCCCCCCCCHH		27545962
241	Phosphorylation	TPPSGIGTTLDECFD CCCCCCCCCHHHHHH		27545962
242	Phosphorylation	PPSGIGTTLDECFDI CCCCCCCCHHHHHHH		27545962
339	Phosphorylation	MGVHTGDSITVAPAQ CCCCCCCCEEECCCC		28011693
341	Phosphorylation	VHTGDSITVAPAQTL CCCCCCEEECCCCCC		28011693
423	Phosphorylation	AKLSVGYTLDQIPND HHHCCCEEHHHCCCC		19880383
576	Phosphorylation	SGTLSEITKEDLYEV HCCHHHCCHHHHHHH		19880383
828	Sulfoxidation	YVLGGRAMEIVYDDS HEECCEEEEEEECHH		23289948
835	Phosphorylation	MEIVYDDSRLITYLE EEEEECHHHHHHHHH		27531888
974	Sulfoxidation	AKYAALVMSGKSLKD HHHHHHHHCCCCHHH		25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARB_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARB_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARB_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CARA_ARATH	CARA	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.