CAPZB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAPZB_RAT
• UniProt AC: Q5XI32
• Protein Name: F-actin-capping protein subunit beta
• Gene Name: Capzb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 272
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere.
• Protein Description: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity)..
• Protein Sequence: MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDQQLDCA ------CCHHHHHHH	44.09	-
2	Phosphorylation	------MSDQQLDCA ------CCHHHHHHH	44.09	27097102
78	Acetylation	YRSPWSNKYDPPLED CCCCCCCCCCCCCCC	45.58	22902405
95	Acetylation	MPSARLRKLEVEANN CCCHHHHHHHHHHCC	54.30	22902405
182	Phosphorylation	LWLQTNKSGSGTMNL EEEEECCCCCCEEEC	40.02	23984901
184	Phosphorylation	LQTNKSGSGTMNLGG EEECCCCCCEEECCC	37.88	23984901
186	Phosphorylation	TNKSGSGTMNLGGSL ECCCCCCEEECCCCC	12.46	23984901
199	Acetylation	SLTRQMEKDETVSDC CCCHHHHCCCCHHHC	56.36	83036239
204	Phosphorylation	MEKDETVSDCSPHIA HHCCCCHHHCCHHHH	40.08	-
223	Acetylation	LVEDMENKIRSTLNE HHHHHHHHHHHHHHH	26.62	22902405
235	Acetylation	LNEIYFGKTKDIVNG HHHHHCCCHHHHHHH	42.37	22902405
235	Ubiquitination	LNEIYFGKTKDIVNG HHHHHCCCHHHHHHH	42.37	-
252	Acetylation	SVQTFADKSKQEALK HHHHHCCHHHHHHHH	57.00	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAPZB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAPZB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAPZB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CAPZB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.